YRC Public Data Repository - Protein Structure Prediction

Protein:	TYSY_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	304 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYSY_YEAST.

Description	E-value	Query Range	Subject Range
TYSY_YEAST - Thymidylate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC21 PE=1 SV=1 gi\|190407409 - gi\|190407409\|gb\|EDV10676.1\| thymidylate synthase [Saccharomyces cerevisiae RM11-1a] CDC21 - Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expressi...	0.0	[1..304]	[1..304]
TYSY_MOUSE - Thymidylate synthase OS=Mus musculus GN=Tyms PE=1 SV=1	0.0	[1..304]	[15..307]
DRTS_MAIZE - Bifunctional dihydrofolate reductase-thymidylate synthase OS=Zea mays GN=DRTS PE=2 SV=1	0.0	[2..304]	[230..521]
gi\|15988342, gi\|... - gi\|15988345\|pdb\|1JUJ\|D Chain D, Human Thymidylate Synthase Bound To Dump And Ly231514, A Pyrrolo(2,3...	0.0	[8..304]	[28..313]
TYSY_RAT - Thymidylate synthase OS=Rattus norvegicus GN=Tyms PE=1 SV=1	0.0	[8..304]	[22..307]

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Predicted Domain #1

Region A:
Residues: [1-71]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMDGKNKEE EQYLDLCKRI IDEGEFRPDR TGTGTLSLFA PPQLRFSLRD DTFPLLTTKK  60
   61 VFTRGIILEL L

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [142-162]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLKQVIHKLK TNPYDRRIIM S

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [177-304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CHIFSQFYVS FPKEGEGSGK PRLSCLLYQR SCDMGLGVPF NIASYALLTR MIAKVVDMEP  60
   61 GEFIHTLGDA HVYKDHIDAL KEQITRNPRP FPKLKIKRDV KDIDDFKLTD FEIEDYNPHP 120
  121 RIQMKMSV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1339.0
Match:	1ci7A_
Description:	Thymidylate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [72-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WFLAGDTDAN LLSEQGVKIW DGNGSREYLD KMGFKDRKVG DLGPVYGFQW RHFGAKYKTC  60
   61 DDDYTGQGID

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [163-176]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AWNPADFDKM ALPP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1339.0
Match:	1ci7A_
Description:	Thymidylate synthase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits