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View Structure Prediction Details

Protein: TAX4_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 604 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAX4_YEAST.

Description E-value Query
Range
Subject
Range
TAX4_YEAST - Protein TAX4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAX4 PE=1 SV=1
TAX4 - EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and...
0.0 [1..604] [1..604]
IRS4_SCHPO - Increased rDNA silencing protein 4 homolog OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
SPAC1687.09 - conserved fungal protein
0.0 [84..560] [858..1331]
ITSN1 - intersectin 1 (SH3 domain protein)
3.0E-35 [466..599] [215..357]
EPS15_MOUSE - Epidermal growth factor receptor substrate 15 OS=Mus musculus GN=Eps15 PE=1 SV=1
3.0E-34 [466..602] [218..352]

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Predicted Domain #1
Region A:
Residues: [1-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHFPKKKHSG NLSVVELPKE ALQDSLTAAQ ITFKRYAHPN GNAGSAERPR HLKVESAPVV  60
   61 KSEPSLPRMR QPEPRSINHQ YSRETLPGHS EAFSVPTTPL QTIHYDVRNK ASNSPSSIAA 120
  121 AETAAYLAHT NSFSNRSSGV GSRDPVMDTE TKPPRAPSAL KNELQLNRMR IPPPSYDNNV 180
  181 RSRSISPQVS YSTSLSSSCS ISSDGEETSY REKSTDEAFP PEPSMSSYSL ASKASAKASL 240
  241 TDPSQRQQES DYTAMNKLNG GNIIYKGTLP DLIPRSQRKT SKPRFKHRLL RSPEQQQENL 300
  301 SRVYSDQTQN GRAIINTQQN VKLKTTMRRG KYAITDNDET FPYDRKSVSS DSDTDEDSNV 360
  361 MEIKDKKKKS RRSKIKKGLK TTAAVVGSST SVLPFPHHHH HHHQLHNPNS HHLHTHHHTS 420
  421 SHKFNEDKPW KSH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [434-604]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDLGFITEQE RKRYESMWVS NRYSYLRLLP WWPSLANEDD ESHLQPLNLP QDGLMLNLVV  60
   61 KDIWYRSNLP RDLLVQIYNM VDTRKDGTLD RKSFIVGMWL VDQCLYGRKL TNELDQRVWN 120
  121 SVDGYVLGTI NVKPATSDHY HNANNPLDKP SKLSVRQELK NIKRDLRNVR I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.274545
Match: 1c07A_
Description: Eps15
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.53567454488695 bayes_pls_golite062009
protein binding 1.16246005294206 bayes_pls_golite062009
ion binding 0.748522810620974 bayes_pls_golite062009
cation binding 0.747391827600734 bayes_pls_golite062009
metal ion binding 0.747391827600734 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle