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View Structure Prediction Details

Protein: SLF1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 447 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLF1_YEAST.

Description E-value Query
Range
Subject
Range
SLF1_YEAST - Protein SLF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLF1 PE=1 SV=1
SLF1 - RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA trans...
0.0 [1..447] [1..447]
gi|3882183 - gi|3882183|dbj|BAA34451.1| KIAA0731 protein [Homo sapiens]
7.0E-63 [29..360] [118..488]
LRP1A_ARATH - La-related protein 1A OS=Arabidopsis thaliana GN=LARP1A PE=1 SV=1
3.0E-57 [32..447] [22..433]
CG17386-PA, FBpp... - This gene is referred to in FlyBase by the symbol Dmel\CG17386 (CG17386, FBgn0033936). It is a prote...
1.0E-51 [22..446] [29..449]
SPAC1527.03 - RNA-binding protein
YLA3_SCHPO - Uncharacterized HTH La-type RNA-binding protein C1527.03 OS=Schizosaccharomyces pombe (strain 972 / ...
2.0E-51 [2..383] [52..416]
LA_MOUSE - Lupus La protein homolog OS=Mus musculus GN=Ssb PE=1 SV=1
2.0E-49 [263..444] [5..198]
LA_BOVIN - Lupus La protein homolog (La ribonucleoprotein) (La autoantigen homolog) - Bos taurus (Bovine)
8.0E-48 [263..444] [5..198]

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Predicted Domain #1
Region A:
Residues: [1-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQNLNDNP KNTSSAAEDK KKQTSSLKLA PIPTTSPWKS SSPDSNTVIP VEELRDISKT  60
   61 AKPSKNGSGS IKLTSNTKWT PITPSVIISG SKDTNSKSGK NSKNSKTNKK MKKRGKYNND 120
  121 INKKDFNGQT NSTSEISNVS NLESKPLDAN AKVNIHSSSG ATANGNIKRI TNNNNSTNGR 180
  181 QSRNYQNRNG KTRYNNNSRH SQAANNAISF PNNYQARPEY IPNASHWLNN NSRNSYKQLS 240
  241 YFRQQQYYNN INYQQQL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.16
Match: 1i3qA
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [258-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTPYYYSMEP IFKSIESIKN QIEFYFSEEN LKTDEFLRSK FKKANDGFIP MSLIGKFYRM  60
   61 VNLSLGGDPN LILASMREVL QHKETNHLEI ALGSIEGAQK NMADDF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
mRNA binding 4.52007814408702 bayes_pls_golite062009
RNA binding 4.50438526063124 bayes_pls_golite062009
nucleic acid binding 3.64594243387558 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
structural constituent of ribosome 2.95301685898669 bayes_pls_golite062009
structural molecule activity 2.78501986457503 bayes_pls_golite062009
1.49431666307335 bayes_pls_golite062009
poly(U) RNA binding 1.35467931535417 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
single-stranded RNA binding 0.90573796517364 bayes_pls_golite062009
transcription regulator activity 0.737458867828906 bayes_pls_golite062009
DNA binding 0.691258294213766 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
poly-pyrimidine tract binding 0.32812362201346 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [364-447]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPLENYFIRR ENWAEYAMES NFDENDDETE KYNIEKLLGP NDLDNYSYMG YPNFFPSNEN  60
   61 GKKSQSYDQG EISRQFEQNL QIND

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle