YRC Public Data Repository - Protein Structure Prediction

Protein:	NU159_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	1460 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NU159_YEAST.

Description	E-value	Query Range	Subject Range
NUP159 - Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, ... NU159_YEAST - Nucleoporin NUP159 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUP159 PE=1 SV=1	0.0	[1..1460]	[1..1460]
SPBPJ4664.02 - glycoprotein YHU2_SCHPO - Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 OS=Schizosaccharomyces pombe (str...	7.0E-78	[57..1328]	[1071..2356]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-64	[149..1278]	[14..1123]
MUC1 - mucin 1, cell surface associated	1.0E-60	[159..1204]	[16..1041]
gi\|15828996 - gi\|15828996\|ref\|NP_326356.1\| lipoprotein VSAC (fragment) [Mycoplasma pulmonis UAB CTIP] gi\|14089939, gi\|... - pir\|\|E90577 lipoprotein vsaC [imported] - Mycoplasma pulmonis (strain UAB CTIP) (fragment), gi\|14089...	1.0E-58	[381..1179]	[22..833]

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Predicted Domain #1

Region A:
Residues: [1-132]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLKDEVPT ETSEDFGFKF LGQKQILPSF NEKLPFASLQ NLDISNSKSL FVAASGSKAV  60
   61 VGELQLLRDH ITSDSTPLTF KWEKEIPDVI FVCFHGDQVL VSTRNALYSL DLEELSEFRT 120
  121 VTSFEKPVFQ LK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
nucleocytoplasmic transporter activity	7.36869426424539	bayes_pls_golite062009
transporter activity	2.55928656852707	bayes_pls_golite062009
binding	1.85720332251545	bayes_pls_golite062009
structural molecule activity	1.15400876251633	bayes_pls_golite062009
protein binding	0.756333887228113	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [133-609]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVNNTLVILN SVNDLSALDL RTKSTKQLAQ NVTSFDVTNS QLAVLLKDRS FQSFAWRNGE  60
   61 MEKQFEFSLP SELEELPVEE YSPLSVTILS PQDFLAVFGN VISETDDEVS YDQKMYIIKH 120
  121 IDGSASFQET FDITPPFGQI VRFPYMYKVT LSGLIEPDAN VNVLASSCSS EVSIWDSKQV 180
  181 IEPSQDSERA VLPISEETDK DTNPIGVAVD VVTSGTILEP CSGVDTIERL PLVYILNNEG 240
  241 SLQIVGLFHV AAIKSGHYSI NLESLEHEKS LSPTSEKIPI AGQEQEEKKK NNESSKALSE 300
  301 NPFTSANTSG FTFLKTQPAA ANSLQSQSSS TFGAPSFGSS AFKIDLPSVS STSTGVASSE 360
  361 QDATDPASAK PVFGKPAFGA IAKEPSTSEY AFGKPSFGAP SFGSGKSSVE SPASGSAFGK 420
  421 PSFGTPSFGS GNSSVEPPAS GSAFGKPSFG TPSFGSGNSS AEPPASGSAF GKPSFGT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [610-935]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAFGTASSNE TNSGSIFGKA AFGSSSFAPA NNELFGSNFT ISKPTVDSPK EVDSTSPFPS  60
   61 SGDQSEDESK SDVDSSSTPF GTKPNTSTKP KTNAFDFGSS SFGSGFSKAL ESVGSDTTFK 120
  121 FGTQASPFSS QLGNKSPFSS FTKDDTENGS LSKGSTSEIN DDNEEHESNG PNVSGNDLTD 180
  181 STVEQTSSTR LPETPSDEDG EVVEEEAQKS PIGKLTETIK KSANIDMAGL KNPVFGNHVK 240
  241 AKSESPFSAF ATNITKPSST TPAFSFGNST MNKSNTSTVS PMEEADTKET SEKGPITLKS 300
  301 VENPFLPAKE ERTGESSKKD HNDDPK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [936-1376]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGYVSGSEIS VRTSESAFDT TANEEIPKSQ DVNNHEKSET DPKYSQHAVV DHDNKSKEMN  60
   61 ETSKNNERSG QPNHGVQGDG IALKKDNEKE NFDSNMAIKQ FEDHQSSEED ASEKDSRQSS 120
  121 EVKESDDNMS LNSDRDESIS ESYDKLEDIN TDELPHGGEA FKAREVSASA DFDVQTSLED 180
  181 NYAESGIQTD LSESSKENEV QTDAIPVKHN STQTVKKEAV DNGLQTEPVE TCNFSVQTFE 240
  241 GDENYLAEQC KPKQLKEYYT SAKVSNIPFV SQNSTLRLIE STFQTVEAEF TVLMENIRNM 300
  301 DTFFTDQSSI PLVKRTVRSI NNLYTWRIPE AEILLNIQNN IKCEQMQITN ANIQDLKEKV 360
  361 TDYVRKDIAQ ITEDVANAKE EYLFLMHFDD ASSGYVKDLS THQFRMQKTL RQKLFDVSAK 420
  421 INHTEELLNI LKLFTVKNKR L

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [1377-1460]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDNPLVAKLA KESLARDGLL KEIKLLREQV SRLQLEEKGK KASSFDASSS ITKDMKGFKV  60
   61 VEVGLAMNTK KQIGDFFKNL NMAK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.847	0.169	nuclear pore organization	a.65.1	Annexin

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: