YRC Public Data Repository - Protein Structure Prediction

Protein:	LEUC_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	779 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEUC_YEAST.

Description	E-value	Query Range	Subject Range
LEU1 - Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway LEUC_YEAST - 3-isopropylmalate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU1 PE=1 ...	0.0	[1..779]	[1..779]
LEUC_RHIPU - 3-isopropylmalate dehydratase OS=Rhizomucor pusillus GN=LEUA PE=3 SV=1	0.0	[9..779]	[2..755]
LEU2_PHYBL, LEUC... - 3-isopropylmalate dehydratase OS=Phycomyces blakesleeanus GN=leu1 PE=3 SV=2, 3-isopropylmalate dehyd... LEUC_PHYB8 - 3-isopropylmalate dehydratase OS=Phycomyces blakesleeanus (strain ATCC 8743b / FGSC 10004 / NBRC 330...	0.0	[10..779]	[3..744]
LEUC_RHINI - 3-isopropylmalate dehydratase OS=Rhizopus niveus GN=LEU1 PE=3 SV=1	0.0	[10..779]	[3..750]
LEUC_CANMA - 3-isopropylmalate dehydratase OS=Candida maltosa GN=LEU1 PE=3 SV=1	0.0	[9..779]	[3..770]
LEUC_SCHPO - 3-isopropylmalate dehydratase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=leu2 PE=1 SV... leu2 - 3-isopropylmalate dehydratase Leu2	0.0	[9..779]	[8..758]
LEUC_USTMA, LEU2... - 3-isopropylmalate dehydratase OS=Ustilago maydis GN=LEU1 PE=3 SV=1, 3-isopropylmalate dehydratase - ... LEUC_USTMA - 3-isopropylmalate dehydratase OS=Ustilago maydis (strain 521 / FGSC 9021) GN=LEU1 PE=3 SV=1	0.0	[9..779]	[3..773]
gi\|9501741 - gi\|9501741\|emb\|CAB99455.1\| 3-isopropylmalate dehydratase [Yarrowia lipolytica]	0.0	[9..725]	[2..711]
ACO1_ARATH - Aconitate hydratase 1 OS=Arabidopsis thaliana GN=ACO1 PE=1 SV=2	0.0	[14..739]	[65..890]

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Predicted Domain #1

Region A:
Residues: [1-545]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYTPSKGPR TLYDKVFDAH VVHQDENGSF LLYIDRHLVH EVTSPQAFEG LENAGRKVRR  60
   61 VDCTLATVDH NIPTESRKNF KSLDTFIKQT DSRLQVKTLE NNVKQFGVPY FGMSDARQGI 120
  121 VHTIGPEEGF TLPGTTVVCG DSHTSTHGAF GSLAFGIGTS EVEHVLATQT IIQAKSKNMR 180
  181 ITVNGKLSPG ITSKDLILYI IGLIGTAGGT GCVIEFAGEA IEALSMEARM SMCNMAIEAG 240
  241 ARAGMIKPDE TTFQYTKGRP LAPKGAEWEK AVAYWKTLKT DEGAKFDHEI NIEAVDVIPT 300
  301 ITWGTSPQDA LPITGSVPDP KNVTDPIKKS GMERALAYMG LEPNTPLKSI KVDKVFIGSC 360
  361 TNGRIEDLRS AAAVVRGQKL ASNIKLAMVV PGSGLVKKQA EAEGLDKIFQ EAGFEWREAG 420
  421 CSICLGMNPD ILDAYERCAS TSNRNFEGRQ GALSRTHLMS PAMAAAAGIA GHFVDIREFE 480
  481 YKDQDQSSPK VEVTSEDEKE LESAAYDHAE PVQPEDAPQD IANDELKDIP VKSDDTPAKP 540
  541 SSSGM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [571-575]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQFLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1276.9897
Match:	5acn__
Description:	Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [546-570]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPFLTLEGIS APLDKANVDT DAIIP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [576-779]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIKRTGLKKG LFYEWRFRKD DQGKDQETDF VLNVEPWREA EILVVTGDNF GCGSSREHAP  60
   61 WALKDFGIKS IIAPSYGDIF YNNSFKNGLL PIRLDQQIII DKLIPIANKG GKLCVDLPNQ 120
  121 KILDSDGNVL VDHFEIEPFR KHCLVNGLDD IGITLQKEEY ISRYEALRRE KYSFLEGGSK 180
  181 LLKFDNVPKR KAVTTTFDKV HQDW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1276.9897
Match:	5acn__
Description:	Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits