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View Structure Prediction Details

Protein: HEH2_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 663 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEH2_YEAST.

Description E-value Query
Range
Subject
Range
HEH2 - Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localizati...
HEH2_YEAST - Inner nuclear membrane protein HEH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEH2...
0.0 [1..663] [1..663]
SPAC18G6.10 - chromosome segregation protein
LEM2_SCHPO - Lap-Emerin-Man domain protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lem2 PE=1 ...
0.0 [5..661] [8..665]
gi|6473492 - gi|6473492|dbj|BAA87142.1| Hypothetical protein [Schizosaccharomyces pombe]
2.0E-51 [484..661] [1..198]
gi|8163674 - gi|8163674|gb|AAF73795.1|AF154026_1 surface protein PspC [Streptococcus pneumoniae]
1.0E-46 [4..313] [139..442]
gi|25509405, gi|... - gi|8163644|gb|AAF73779.1| surface protein PspC [Streptococcus pneumoniae], pir||H98120 choline bindi...
gi|15459699, gi|... - gi|15904036|ref|NP_359586.1| choline binding protein A [Streptococcus pneumoniae R6], gi|15459699|gb...
gi|116515359, gi... - gi|8163644|gb|AAF73779.1|AF154012_1 surface protein PspC [Streptococcus pneumoniae], gi|116515359|re...
2.0E-44 [4..316] [139..451]

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Predicted Domain #1
Region A:
Residues: [1-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHRNLDPKT LKVSQLRRVL VENDVAFPAN ARKPVLVKLF EEKVRQRLQS SPEASKVRTS  60
   61 IQKVVKSGAK NADRKKTLKS KKLESSSSES KTVKDENVET NKRKREQIST DNEAKMQIQE 120
  121 EKSPKKKRKK RSSKANKPPE SPPQSKSDGK ATSADLTSEL ETVEELHKKD SSDDKPRVKE 180
  181 LPKPELPNLK VSNEFLAQLN KELASAATEN YDHSIKSTDL SSIRIETEEP VGPSTGAETR 240
  241 NESEVMENIN LEVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [255-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEVKEAKEEL TKISETFDNQ DEEDTSRLSS KKNIRSPKGR TRHFIANKTK RGIDIMKPFI  60
   61 AHLFIWLWNG AIFLSIICPI LFGLWYREQR IQVGYCGHEK PLKSLAISAF PQTERVDSVL 120
  121 QAYRPNCLEC PEHGICSSFM NVECEPGYEP KSSILETYGI IPFPKYCAKD ESKEKEVDEL 180
  181 VWKVNEYLKK KNAQHECGEG ENLFESGETE TKLYDIFSHS RPSWESQREF NDHWKNVLEI 240
  241 LKKKDDIIWL PLDFETNGKR EKSKSNN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [522-663]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNYIYRSTSK KWVTLQCHLE GDIQEYITKY GGSLFITLGV LFLIKKIQST LDNYVQGEQI  60
   61 IEKLVKEAID KLKDVKKNKG EEPFLTTVQL RATLLSDIPN IKEQNNLWAQ TKEKIMKEQS 120
  121 ENIELYLLEE NGEIMTCWEW KE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.809 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.695 N/A N/A d.52.2 GMP synthetase C-terminal dimerisation domain
View Download 0.659 N/A N/A a.1.1 Globin-like
View Download 0.604 N/A N/A a.1.1 Globin-like
View Download 0.576 N/A N/A a.7.4 Smac/diablo
View Download 0.540 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.529 N/A N/A c.95.1 Thiolase-like
View Download 0.517 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.517 N/A N/A a.118.1 ARM repeat
View Download 0.513 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.470 N/A N/A a.7.1 Spectrin repeat
View Download 0.469 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.468 N/A N/A a.126.1 Serum albumin-like
View Download 0.464 N/A N/A a.69.2 Ypt/Rab-GAP domain of gyp1p
View Download 0.464 N/A N/A a.7.1 Spectrin repeat
View Download 0.444 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.441 N/A N/A b.60.1 Lipocalins
View Download 0.438 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.437 N/A N/A a.26.1 4-helical cytokines
View Download 0.433 N/A N/A d.58.19 Bacterial exopeptidase dimerisation domain
View Download 0.428 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.426 N/A N/A a.74.1 Cyclin-like
View Download 0.419 N/A N/A a.63.1 Apolipophorin-III
View Download 0.416 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.398 N/A N/A d.146.1 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
View Download 0.390 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.384 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.382 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.380 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.378 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.377 N/A N/A a.19.1 Fertilization protein
View Download 0.374 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.363 N/A N/A c.23.14 Nucleoside 2-deoxyribosyltransferase
View Download 0.363 N/A N/A a.25.1 Ferritin-like
View Download 0.359 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.357 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.354 N/A N/A c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.353 N/A N/A a.1.1 Globin-like
View Download 0.345 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.341 N/A N/A d.123.1 Sporulation responce regulatory protein Spo0B
View Download 0.339 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.338 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.337 N/A N/A d.65.1 Hedgehog/DD-pepidase
View Download 0.328 N/A N/A a.25.1 Ferritin-like
View Download 0.321 N/A N/A d.112.1 Phoshotransferase/anion transport protein
View Download 0.320 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.318 N/A N/A c.95.1 Thiolase-like
View Download 0.315 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.313 N/A N/A d.2.1 Lysozyme-like
View Download 0.307 N/A N/A f.4.1 OMPA-like
View Download 0.307 N/A N/A a.47.1 STAT
View Download 0.301 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.300 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.299 N/A N/A c.23.16 Class I glutamine amidotransferase-like
View Download 0.285 N/A N/A d.60.1 Probable bacterial effector-binding domain
View Download 0.283 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.281 N/A N/A e.34.1 NSP3 homodimer
View Download 0.279 N/A N/A a.39.1 EF-hand
View Download 0.263 N/A N/A c.53.1 Resolvase-like
View Download 0.258 N/A N/A d.24.1 Pili subunits
View Download 0.257 N/A N/A a.167.1 Porin chaperone SurA, peptide-binding domain
View Download 0.257 N/A N/A a.118.1 ARM repeat
View Download 0.255 N/A N/A a.131.1 Peridinin-chlorophyll protein
View Download 0.249 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.246 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.238 N/A N/A a.47.2 t-snare proteins
View Download 0.237 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.229 N/A N/A a.4.1 Homeodomain-like
View Download 0.229 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.226 N/A N/A a.24.4 Hemerythrin
View Download 0.224 N/A N/A a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.220 N/A N/A d.73.1 RuBisCO, small subunit
View Download 0.219 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.212 N/A N/A c.108.1 HAD-like
View Download 0.211 N/A N/A d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.208 N/A N/A a.2.5 Prefoldin
View Download 0.207 N/A N/A d.162.1 LDH C-terminal domain-like
View Download 0.206 N/A N/A d.135.1 The spindle assembly checkpoint protein mad2
View Download 0.205 N/A N/A a.118.1 ARM repeat
View Download 0.204 N/A N/A a.24.17 Group V grass pollen allergen


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle