YRC Public Data Repository - Protein Structure Prediction

Protein:	CFT2_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	859 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CFT2_YEAST.

Description	E-value	Query Range	Subject Range
gi\|151941280 - gi\|151941280\|gb\|EDN59658.1\| cleavage factor II (CF II) component [Saccharomyces cerevisiae YJM789] CFT2_YEAST - Cleavage factor two protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CFT2 PE=1 ... CFT2 - Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, poly...	0.0	[1..859]	[1..859]
CPSF2_MOUSE - Cleavage and polyadenylation specificity factor subunit 2 OS=Mus musculus GN=Cpsf2 PE=1 SV=1	0.0	[1..859]	[1..782]
CPSF2_BOVIN - Cleavage and polyadenylation specificity factor subunit 2 OS=Bos taurus GN=CPSF2 PE=1 SV=1	0.0	[1..859]	[1..782]
gi\|9082326 - gi\|9082326\|gb\|AAF82809.1\|AF283277_1 polyadenylation cleavage/specificity factor 100 kDa subunit [Ara...	0.0	[1..856]	[1..736]
gi\|18029276, gi\|... - gi\|18029276\|gb\|AAL56454.1\| cleavage and polyadenylation factor-like protein [Oikopleura dioica], gi\|...	0.0	[1..859]	[1..765]
cpsf-2 - status:Confirmed UniProt:O17403 protein_id:AAB71322.1	0.0	[1..858]	[1..842]
CPSF2 - cleavage and polyadenylation specific factor 2, 100kDa gi\|114654443, gi... - gi\|114654443\|ref\|XP_001147356.1\| PREDICTED: cleavage and polyadenylation specific factor 2 isoform 4...	0.0	[220..859]	[6..579]
CFT2_SCHPO - Cleavage factor two protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cft2 PE=1 SV... cft2 - cleavage factor two Cft2 /polyadenylation factor CPSF-73	0.0	[3..859]	[2..797]

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Predicted Domain #1

Region A:
Residues: [1-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTYKYNCCDD GSGTTVGSVV RFDNVTLLID PGWNPSKVSY EQCIKYWEKV IPEIDVIILS  60
   61 QPTIECLGAH SLLYYNFTSH FISRIQVYAT LPVINLGRVS TIDSYASAGV IGPYDTNKLD 120
  121 LEDIEISFDH IVPLKYSQLV DLRSRYDGLT LLAYNAGVCP GGSIWCISTY SEKLVYAKRW 180
  181 NHTRDNILNA ASILDATGKP LSTLMRPSAI ITTLDRFGSS QPFKKRSKIF KDTLKKGLSS 240
  241 DGSVIIPVDM SGKFLDLFTQ VHELLFESTK INA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.69897
Match:	1e5dA_
Description:	Rubredoxin oxygen:oxidoreductase (ROO), C-terminal domain; Rubredoxin oxygen:oxidoreductase (ROO), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.97803450114143	bayes_pls_golite062009
nucleic acid binding	1.66507162669272	bayes_pls_golite062009
RNA binding	1.48455378212673	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
protein binding	0.380466845099285	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [274-481]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTQVPVLILS YARGRTLTYA KSMLEWLSPS LLKTWENRNN TSPFEIGSRI KIIAPNELSK  60
   61 YPGSKICFVS EVGALINEVI IKVGNSEKTT LILTKPSFEC ASSLDKILEI VEQDERNWKT 120
  121 FPEDGKSFLC DNYISIDTIK EEPLSKEETE AFKVQLKEKK RDRNKKILLV KRESKKLANG 180
  181 NAIIDDTNGE RAMRNQDILV ENVNGVPP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [482-859]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDHIMGGDED DDEEEENDNL LNLLKDNSEK SAAKKNTEVP VDIIIQPSAA SKHKMFPFNP  60
   61 AKIKKDDYGT VVDFTMFLPD DSDNVNQNSR KRPLKDGAKT TSPVNEEDNK NEEEDGYNMS 120
  121 DPISKRSKHR ASRYSGFSGT GEAENFDNLD YLKIDKTLSK RTISTVNVQL KCSVVILNLQ 180
  181 SLVDQRSASI IWPSLKSRKI VLSAPKQIQN EEITAKLIKK NIEVVNMPLN KIVEFSTTIK 240
  241 TLDISIDSNL DNLLKWQRIS DSYTVATVVG RLVKESLPQV NNHQKTASRS KLVLKPLHGS 300
  301 SRSHKTGALS IGDVRLAQLK KLLTEKNYIA EFKGEGTLVI NEKVAVRKIN DAETIIDGTP 360
  361 SELFDTVKKL VTDMLAKI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: