YRC Public Data Repository - Protein Structure Prediction

Protein:	CDC73_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	393 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC73_YEAST.

Description	E-value	Query Range	Subject Range
CDC73_ARATH - Protein CDC73 homolog OS=Arabidopsis thaliana GN=CDC73 PE=1 SV=1	448.0	[0..30]	[392..15]
gi\|25334124, gi\|... - gi\|3859701\|emb\|CAA21976.1\| unknown conserved hypothetical protein [Candida albicans], pir\|\|T52156 hy... gi\|46443118, gi\|... - gi\|68469389\|ref\|XP_721209.1\| potential RNA Pol II elongation accessory factor [Candida albicans SC53...	444.0	[0..20]	[392..23]
gi\|50290939, gi\|... - gi\|50290939\|ref\|XP_447902.1\| unnamed protein product [Candida glabrata], gi\|49527213\|emb\|CAG60851.1\|... gi\|49527213 - gi\|49527213\|emb\|CAG60851.1\| unnamed protein product [Candida glabrata]	392.0	[0..5]	[393..4]
CDC73_SCHPO - Cell division control protein 73 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cdc73 PE=... SPBC17G9.02c - RNA polymerase II accessory factor, Cdc73 family	373.0	[0..27]	[390..22]
gi\|49642337 - gi\|49642337\|emb\|CAH00299.1\| KLLA0D03036p [Kluyveromyces lactis] gi\|49642337, gi\|... - gi\|50306459\|ref\|XP_453203.1\| unnamed protein product [Kluyveromyces lactis], gi\|49642337\|emb\|CAH0029...	349.0	[0..5]	[392..3]
gi\|44983680 - gi\|44983680\|gb\|AAS52779.1\| AER095Wp [Ashbya gossypii ATCC 10895] gi\|45190701, gi\|... - gi\|45190701\|ref\|NP_984955.1\| AER095Wp [Ashbya gossypii ATCC 10895], gi\|44983680\|gb\|AAS52779.1\| AER09...	338.0	[0..5]	[392..3]
gi\|50420559, gi\|... - gi\|50420559\|ref\|XP_458816.1\| hypothetical protein DEHA0D08954g [Debaryomyces hansenii CBS767], gi\|49... gi\|49654483\|emb\|... - unnamed protein product [Debaryomyces hansenii CBS767]	329.0	[0..5]	[392..7]
gi\|50543170, gi\|... - gi\|50543170\|ref\|XP_499751.1\| YALI0A04345p [Yarrowia lipolytica], gi\|49645616\|emb\|CAG83675.1\| YALI0A0... gi\|49645616 - gi\|49645616\|emb\|CAG83675.1\| YALI0A04345p [Yarrowia lipolytica]	277.0	[0..3]	[393..2]
CDC73_RAT - Parafibromin OS=Rattus norvegicus GN=Cdc73 PE=2 SV=1	253.0	[0..178]	[388..277]
gi\|109019026 - gi\|109019026\|ref\|XP_001112553.1\| PREDICTED: similar to hyperparathyroidism 2 homolog isoform 2 [Maca... gi\|125630647, gi... - gi\|87042750\|gb\|ABD16382.1\| hyperparathyroidism 2 with jaw tumor protein [Canis familiaris], gi\|74005... CDC73_MOUSE - Parafibromin OS=Mus musculus GN=Cdc73 PE=1 SV=1 CDC73 - cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) gi\|114568508 - gi\|114568508\|ref\|XP_001167188.1\| PREDICTED: hypothetical protein LOC745351 isoform 2 [Pan troglodyte... tr\|F2Z3T0\|F2Z3T0_RAT - Uncharacterized protein OS=Rattus norvegicus GN=Cdc73 PE=4 SV=1 tr\|M3VUK6\|M3VUK6... - Cell division cycle 73 OS=Felis catus GN=CDC73 PE=4 SV=1 gi\|194673899 - gi\|194673899\|ref\|XP_001787504.1\| PREDICTED: similar to Vcell division cycle 73, Paf1/RNA polymerase ... gi\|190691061, gi... - gi\|190691061\|gb\|ACE87305.1\| cell division cycle 73, Paf1/RNA polymerase II complex component, homolo... tr\|G1TBE7\|G1TBE7... - pep:novel chromosome:oryCun2:16:77557694:77687734:-1 gene:ENSOCUG00000016332 transcript:ENSOCUT00000...	252.0	[0..178]	[388..277]

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Predicted Domain #1

Region A:
Residues: [1-133]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSLDRLRE HLKNGDKLVL KNNEGQSTDD ITKATMVETL SSDGSTQDSF PLNEETEIEI  60
   61 DGSLVQLRII VHCWMNKDSS AADYLADCQN KQLTNVSFLQ RTDLINWLSG NTESSQYLKA 120
  121 PGQKGETSDK VDI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.518	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.489	c.78.1	Aspartate/ornithine carbamoyltransferase
View	Download	0.484	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.482	c.78.1	Aspartate/ornithine carbamoyltransferase
View	Download	0.417	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.417	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.416	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.377	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.370	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.367	c.2.1	NAD(P)-binding Rossmann-fold domains

Predicted Domain #2

Region A:
Residues: [134-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENKTLAGELS TVKSTTSASL ENDSEVSDPV VVETMKHERI LVDHNSALRG AKPINFGYLI  60
   61 KDAELKLVQS IKGSLRGSKL PPGHKGAHGR ISKTNGSSGG PRKDPIILIP SAASSILTVA 120
  121 NIKQFLLESK YVNPRNLPSV PNGLVNIEKN FERISRPIRF IIVDNTRMFT KPEYWDRVVA 180
  181 IFTTGHTWQF NNYQWNSPQE LFQRCKGYYF HFAGDSVPQH VQQWNVEKVE LDKNKRFKDV 240
  241 EVVRYFWHSL EKELISRGYR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits