YRC Public Data Repository - Protein Structure Prediction

Protein:	AIM2_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	246 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AIM2_YEAST.

Description	E-value	Query Range	Subject Range
gi\|25530228 - pir\|\|AB2404 hypothetical protein alr4786 [imported] - Nostoc sp. (strain PCC 7120) gi\|17232278, gi\|... - gi\|17232278\|ref\|NP_488826.1\| hypothetical protein alr4786 [Nostoc sp. PCC 7120], gi\|17133923\|dbj\|BAB...	1.0E-41	[1..244]	[3..249]
gi\|25499550, gi\|... - gi\|25499550\|pir\|\|F86070 probable enzyme Z5352 [imported] - Escherichia coli (strain O157:H7, substra... gi\|12518707, gi\|... - gi\|15804422\|ref\|NP_290462.1\| putative enzyme [Escherichia coli O157:H7 EDL933], gi\|12518707\|gb\|AAG59... gi\|13364236, gi\|... - gi\|15834014\|ref\|NP_312787.1\| hypothetical protein ECs4760 [Escherichia coli O157:H7], gi\|13364236\|db... gi\|13364236, gi\|... - gi\|15834014\|ref\|NP_312787.1\| hypothetical protein ECs4760 [Escherichia coli O157:H7 str. Sakai], gi\|...	2.0E-38	[1..243]	[23..287]
gi\|13363356, gi\|... - gi\|15833138\|ref\|NP_311911.1\| hypothetical protein ECs3884 [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|25391410 - pir\|\|D91114 hypothetical protein ECs3884 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|13363356, gi\|... - gi\|15833138\|ref\|NP_311911.1\| hypothetical protein ECs3884 [Escherichia coli O157:H7], gi\|13363356\|db... gi\|217320027, gi... - gi\|217327660\|ref\|ZP_03443743.1\| dienelactone hydrolase family protein [Escherichia coli O157:H7 str.... gi\|189374143, gi... - gi\|189374143\|gb\|EDU92559.1\| dienelactone hydrolase family protein [Escherichia coli O157:H7 str. EC8... gi\|168760155, gi... - gi\|189369229\|gb\|EDU87645.1\| dienelactone hydrolase family protein [Escherichia coli O157:H7 str. EC4...	6.0E-37	[11..244]	[69..294]
USF_AQUPY - Protein usf OS=Aquifex pyrophilus GN=usf PE=4 SV=1	2.0E-36	[30..245]	[14..231]
gi\|62130068, gi\|... - gi\|62182435\|ref\|YP_218852.1\| dienelactone hydrolase family protein [Salmonella enterica subsp. enter... DLHH_SALTY - Putative carboxymethylenebutenolidase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720... gi\|224470310, gi... - gi\|224585782\|ref\|YP_002639581.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Par... DLHH_SALTY - Putative carboxymethylenebutenolidase OS=Salmonella typhimurium GN=ysgA PE=3 SV=1 DLHH_SALTY - Putative carboxymethylenebutenolidase OS=Salmonella typhimurium GN=ysgA PE=3 SV=1 gi\|29143656, gi\|... - gi\|29143656\|ref\|NP_806998.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typhi s... gi\|213027012 - gi\|213027012\|ref\|ZP_03341459.1\| dienelactone hydrolase [Salmonella enterica subsp. enterica serovar ... lcl\|NC_016856.1_... - [gene=dlhH] [protein=putative dienelactone hydrolase] [protein_id=YP_005240232.1] [location=compleme... gi\|213646457 - gi\|213646457\|ref\|ZP_03376510.1\| dienelactone hydrolase [Salmonella enterica subsp. enterica serovar ... gi\|213855538 - gi\|213855538\|ref\|ZP_03383778.1\| dienelactone hydrolase [Salmonella enterica subsp. enterica serovar ... gi\|214002440 - gi\|214002440\|ref\|ZP_03413175.1\| dienelactone hydrolase [Salmonella enterica subsp. enterica serovar ... gi\|161617090, gi... - gi\|161617090\|ref\|YP_001591055.1\| hypothetical protein SPAB_04923 [Salmonella enterica subsp. enteric... gi\|206710970, gi... - gi\|207859167\|ref\|YP_002245818.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Ent...	5.0E-36	[1..243]	[1..265]
gi\|16762167 - gi\|16762167\|ref\|NP_457784.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typhi s... DLHH_SALTI - Putative carboxymethylenebutenolidase OS=Salmonella typhi GN=ysgA PE=3 SV=1 DLHH_SALTI - Putative carboxymethylenebutenolidase OS=Salmonella typhi GN=ysgA PE=3 SV=1	1.0E-35	[1..243]	[1..265]
DLHH_YERPE - Putative carboxymethylenebutenolidase OS=Yersinia pestis GN=YPO3787 PE=3 SV=1 gi\|89104873 - gi\|89104873\|ref\|ZP_01177404.1\| COG0412: Dienelactone hydrolase and related enzymes [Yersinia pestis ... gi\|77633876 - gi\|77633876\|ref\|ZP_00795990.1\| COG0412: Dienelactone hydrolase and related enzymes [Yersinia pestis ... gi\|153997156, gi... - gi\|153997156\|ref\|ZP_02022289.1\| putative carboxymethylenebutenolidase [Yersinia pestis CA88-4125], g... gi\|229837113, gi... - gi\|229837113\|ref\|ZP_04457278.1\| putative carboxymethylenebutenolidase [Yersinia pestis Pestoides A],... gi\|229695838, gi... - gi\|229839472\|ref\|ZP_04459631.1\| putative carboxymethylenebutenolidase [Yersinia pestis biovar Orient... gi\|229900035, gi... - gi\|229900035\|ref\|ZP_04515172.1\| putative carboxymethylenebutenolidase [Yersinia pestis biovar Orient... gi\|115349400, gi... - gi\|218930789\|ref\|YP_002348664.1\| putative carboxymethylenebutenolidase [Yersinia pestis CO92], gi\|16... gi\|229900518, gi... - gi\|229900518\|ref\|ZP_04515647.1\| putative carboxymethylenebutenolidase [Yersinia pestis Nepal516], gi...	2.0E-35	[26..243]	[28..255]
AIM2_YEAST - Protein AIM2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AIM2 PE=1 SV=1 AIM2 - Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced... gi\|151941341 - gi\|151941341\|gb\|EDN59712.1\| conserved protein [Saccharomyces cerevisiae YJM789]	3.0E-35	[1..246]	[1..246]
gi\|89110190, gi\|... - gi\|89110190\|ref\|AP_003970.1\| predicted hydrolase [Escherichia coli str. K-12 substr. W3110], gi\|8567... EG14321 - putative carboxymethylenebutenolidase / Putative carboxymethylenebutenolidase; dienelactone hydrolas... gi\|238902905, gi... - gi\|238902905\|ref\|YP_002928701.1\| putative hydrolase [Escherichia coli BW2952], gi\|238862472\|gb\|ACR64... gi\|157163306, gi... - gi\|157163306\|ref\|YP_001460624.1\| dienelactone hydrolase family protein [Escherichia coli HS], gi\|157... gi\|170083310, gi... - gi\|170083310\|ref\|YP_001732630.1\| hydrolase [Escherichia coli str. K-12 substr. DH10B], gi\|169891145\|... EG14321 - putative carboxymethylenebutenolidase / Putative carboxymethylenebutenolidase; dienelactone hydrolas... DLHH_ECOLI - Putative carboxymethylenebutenolidase (EC 3.1.1.45) (Dienelactone hydrolase) (DLH) - Escherichia col...	8.0E-35	[11..243]	[2..252]

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Predicted Domain #1

Region A:
Residues: [1-246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASNQPGKCC FEGVCHDGTP KGRREEIFGL DTYAAGSTSP KEKVIVILTD VYGNKFNNVL  60
   61 LTADKFASAG YMVFVPDILF GDAISSDKPI DRDAWFQRHS PEVTKKIVDG FMKLLKLEYD 120
  121 PKFIGVVGYC FGAKFAVQHI SGDGGLANAA AIAHPSFVSI EEIEAIDSKK PILISAAEED 180
  181 HIFPANLRHL TEEKLKDNHA TYQLDLFSGV AHGFAARGDI SIPAVKYAKE KVLLDQIYWF 240
  241 NHFSNV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.221849
Match:	1din__
Description:	Dienelactone hydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	0.685577841077355	bayes_pls_golite062009
catalytic activity	0.629869101256762	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.116945164557932	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: