YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS2_CALS4
Organism:	Thermoanaerobacter tengcongensis MB4
Length:	205 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS2_CALS4.

Description	E-value	Query Range	Subject Range
gi\|25290311 - pir\|\|AH2213 histidine biosynthesis bifunctional protein (phosphoribosyl-AMP cyclohydrolase/phosphor... HIS2_NOSS1 - Histidine biosynthesis bifunctional protein HisIE OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=his...	305.0	[0..1]	[204..12]
gi\|75704839, gi\|... - gi\|75911114\|ref\|YP_325410.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrop...	303.0	[0..1]	[204..12]
gi\|167039657, gi... - gi\|167039657\|ref\|YP_001662642.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP p... gi\|242231370, gi... - gi\|242257128\|ref\|ZP_04802003.1\| phosphoribosyl-ATP diphosphatase [Thermoanaerobacter sp. X513], gi\|2...	303.0	[0..1]	[205..1]
gi\|76795717, gi\|... - gi\|76795717\|ref\|ZP_00778089.1\| Phosphoribosyl-AMP cyclohydrolase:Phosphoribosyl-ATP pyrophosphohydro... gi\|241904119, gi... - gi\|241904119\|ref\|ZP_04788828.1\| phosphoribosyl-ATP diphosphatase [Thermoanaerobacter brockii subsp. ...	301.0	[0..1]	[205..1]
gi\|1653965, gi\|1... - gi\|1653965\|dbj\|BAA18875.1\| phosphoribosyl-ATP pyrophosphohydrolase:phosphoribosyl-AMP cyclohydrolase... gi\|7436002 - gi\|7436002\|pir\|\|S76963 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / phosphoribosyl-ATP diphosph...	300.0	[0..2]	[204..27]
gi\|56752110, gi\|... - gi\|56752110\|ref\|YP_172811.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrop... gi\|81300804, gi\|... - gi\|81300804\|ref\|YP_401012.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrop...	300.0	[0..2]	[204..8]
gi\|67924291, gi\|... - gi\|67924291\|ref\|ZP_00517727.1\| Phosphoribosyl-AMP cyclohydrolase:Phosphoribosyl-ATP pyrophosphohydro...	296.0	[0..2]	[204..14]
gi\|23129941, gi\|... - gi\|23129941\|ref\|ZP_00111762.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Nostoc punctiforme PCC 73...	295.0	[0..2]	[204..13]
gi\|71671765, gi\|... - gi\|71674789\|ref\|ZP_00672535.1\| Phosphoribosyl-AMP cyclohydrolase:Phosphoribosyl-ATP pyrophosphohydro...	295.0	[0..2]	[205..13]

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Predicted Domain #1

Region A:
Residues: [1-108]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDIKELKFD EKGLIPAIVQ DYYTKQVLML AYMNEESLKL TLEKGETYFF SRSRGKIWHK  60
   61 GETSGNTQKV KKIFYDCDED ALLIQVEAKG PACHTGNISC FYRSFDEE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.0
Match:	1zpsA
Description:	Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosyl-AMP cyclohydrolase activity	4.150200144507	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	2.23740731288751	bayes_pls_golite062009
catalytic activity	1.39985329737364	bayes_pls_golite062009
cyclohydrolase activity	0.79104127517031	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.54834173729282	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [109-205]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEDGIEILNK LYERIKGRKI NPVEGSYTNY LFEKGIDKIL KKVGEEATEV VIASKNDSKD  60
   61 EIVYEVSDLI YHLMVLLVEK NITLNDIYNE LERRYKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.69897
Match:	1yvwA
Description:	Crystal structure of Phosphoribosyl-ATP pyrophosphohydrolase from Bacillus cereus. NESGC target BcR13.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosyl-ATP diphosphatase activity	3.7001994388833	bayes_pls_golite062009
phosphoribosyl-AMP cyclohydrolase activity	2.61820126109961	bayes_pls_golite062009
catalytic activity	1.00486703080234	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.72725441841528	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: