YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|25527673
Organism:	Brucella melitensis
Length:	251 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25527673.

Description	E-value	Query Range	Subject Range
gi\|83815921, gi\|... - gi\|83815921\|ref\|YP_445581.1\| pyrazinamidase/nicotinamidase [Salinibacter ruber DSM 13855], gi\|837573...	210.0	[0..47]	[248..3]
gi\|254730688 - gi\|254730688\|ref\|ZP_05189266.1\| Isochorismatase hydrolase family protein [Brucella abortus bv. 4 str... gi\|82700278 - gi\|82700278\|ref\|YP_414852.1\| isochorismatase hydrolase family protein [Brucella melitensis biovar Ab... gi\|82616379 - gi\|82616379\|emb\|CAJ11440.1\| Isochorismatase hydrolase family [Brucella melitensis biovar Abortus 230... gi\|189024586, gi... - gi\|189024586\|ref\|YP_001935354.1\| Isochorismatase hydrolase family [Brucella abortus S19], gi\|1890201... gi\|62196487, gi\|... - gi\|62290355\|ref\|YP_222148.1\| PncA, pyrazinamidase/nicotinamidase [Brucella abortus bv. 1 str. 9-941]... gi\|254689656 - gi\|254689656\|ref\|ZP_05152910.1\| Isochorismatase hydrolase family protein [Brucella abortus bv. 6 str... gi\|254697799 - gi\|254697799\|ref\|ZP_05159627.1\| Isochorismatase hydrolase family protein [Brucella abortus bv. 2 str...	208.0	[0..47]	[251..5]
gi\|23348313, gi\|... - gi\|23502333\|ref\|NP_698460.1\| pyrazinamidase/nicotinamidase [Brucella suis 1330], gi\|23348313\|gb\|AAN3...	207.0	[0..47]	[251..5]
gi\|15073509, gi\|... - gi\|8571421\|gb\|AAF76877.1\|AF247710_2 putative pyrazinamidase/nicotinamidase PncA [Sinorhizobium melil... gi\|15964332 - gi\|15964332\|ref\|NP_384685.1\| pyrazinamidase/nicotinamidase (Includes: pyrazinamidase, nicotinamidase...	206.0	[0..34]	[241..4]
gi\|77459112, gi\|... - gi\|77459112\|ref\|YP_348618.1\| nicotinamidase [Pseudomonas fluorescens Pf0-1], gi\|77383115\|gb\|ABA74628...	204.0	[0..39]	[247..1]
gi\|113726274, gi... - gi\|150395426\|ref\|YP_001325893.1\| nicotinamidase [Sinorhizobium medicae WSM419], gi\|150026941\|gb\|ABR5...	202.0	[0..43]	[241..1]
gi\|27375788, gi\|... - gi\|27375788\|ref\|NP_767317.1\| bifunctional pyrazinamidase/nicotinamidase [Bradyrhizobium japonicum US... gi\|6433784 - gi\|6433784\|emb\|CAB60666.1\| hypothetical protein [Bradyrhizobium japonicum]	202.0	[0..20]	[248..9]
gi\|110286520, gi... - gi\|69274774\|ref\|ZP_00610686.1\| Nicotinamidase [Mesorhizobium sp. BNC1], gi\|68193214\|gb\|EAN07866.1\| N...	201.0	[0..39]	[241..1]
gi\|84501486, gi\|... - gi\|84501486\|ref\|ZP_00999691.1\| pyrazinamidase/nicotinamidase [Oceanicola batsensis HTCC2597], gi\|843...	201.0	[0..44]	[240..1]
gi\|13474085, gi\|... - gi\|14024837\|dbj\|BAB51439.1\| pyrazinamidase/nicotinamidase [Mesorhizobium loti MAFF303099], gi\|134740...	201.0	[0..43]	[240..1]

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Predicted Domain #1

Region A:
Residues: [1-251]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKHGKAVPI TNAFVIPERA YLPVSQKLDR YKLIGNNKAE HPMIGHALVV IDVQNDFCPG  60
   61 GALAVERGDE IIPIVNRLIG ESENVVVTQD WHPANHSSFA SNHSGSRPFD TVNMSYGPQV 120
  121 LWPDHCVQNS EGAEFHPDLQ WWRAQLVVRK GFRIGIDSYS AFFENDHCTP TGLGGYLRER 180
  181 NIGSLTMVGL ATDFCVASSA LDAVQQGFQV RVRLDACRGI DLNGSMNIML EKMKQAGVEL 240
  241 IDEPVSASHL L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.0
Match:	1ilwA
Description:	Pyrazinamidase/nicotinamidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinamidase activity	2.590271821288	bayes_pls_golite062009
binding	1.80707112356899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1.33901087189475	bayes_pls_golite062009
catalytic activity	0.992051062697807	bayes_pls_golite062009
protein binding	0.343971697425971	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: