YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|47015090, gi\|...
Organism:	Listeria monocytogenes serotype 1/2a str. F6854
Length:	426 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|47015090, gi|....

Description	E-value	Query Range	Subject Range
gi\|196253633, gi... - gi\|196253633\|ref\|ZP_03152251.1\| dihydroorotase, multifunctional complex type [Clostridium thermocell... gi\|67876353, gi\|... - gi\|67876353\|ref\|ZP_00505240.1\| Dihydroorotase multifunctional complex type [Clostridium thermocellum...	317.0	[0..3]	[422..4]
gi\|254826121 - gi\|254826121\|ref\|ZP_05231122.1\| dihydroorotase [Listeria monocytogenes FSL J1-194] gi\|133726779, gi... - gi\|153167680\|ref\|ZP_01927784.1\| dihydroorotase, multifunctional complex type [Listeria monocytogenes... gi\|254878045 - gi\|254878045\|ref\|ZP_05250755.1\| dihydroorotase [Listeria monocytogenes FSL J2-071] gi\|254931993, gi... - gi\|254931993\|ref\|ZP_05265352.1\| dihydroorotase [Listeria monocytogenes HPB2262], gi\|153202834\|ref\|ZP... gi\|254852743 - gi\|254852743\|ref\|ZP_05242091.1\| dihydroorotase [Listeria monocytogenes FSL R2-503] gi\|255521075 - gi\|255521075\|ref\|ZP_05388312.1\| dihydroorotase [Listeria monocytogenes FSL J1-175] gi\|254993757 - gi\|254993757\|ref\|ZP_05275947.1\| dihydroorotase [Listeria monocytogenes FSL J2-064] PYRC_LISMF - Dihydroorotase OS=Listeria monocytogenes serotype 4b (strain F2365) GN=pyrC PE=3 SV=1 gi\|47093074, gi\|... - gi\|47093074\|ref\|ZP_00230852.1\| dihydroorotase, multifunctional complex type [Listeria monocytogenes ...	315.0	[0..1]	[426..1]
PYRC_LISIN - Dihydroorotase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=pyrC PE=3 SV=1 PYRC_LISIN - Dihydroorotase OS=Listeria innocua GN=pyrC PE=3 SV=1	313.0	[0..1]	[424..1]
gi\|89098723, gi\|... - gi\|89098723\|ref\|ZP_01171605.1\| dihydroorotase [Bacillus sp. NRRL B-14911], gi\|89086685\|gb\|EAR65804.1...	313.0	[0..2]	[425..3]
PYRC_GEOUR - Dihydroorotase OS=Geobacter uraniireducens (strain Rf4) GN=pyrC PE=3 SV=1	312.0	[0..2]	[421..3]
PYRC_STAEQ - Dihydroorotase OS=Staphylococcus epidermidis (strain ATCC 35984 / RP62A) GN=pyrC PE=3 SV=1 gi\|242234057, gi... - gi\|242242483\|ref\|ZP_04796928.1\| dihydroorotase [Staphylococcus epidermidis W23144], gi\|242234057\|gb\|...	312.0	[0..1]	[422..1]
gi\|195991527, gi... - gi\|196035878\|ref\|ZP_03103280.1\| dihydroorotase [Bacillus cereus W], gi\|195991527\|gb\|EDX55493.1\| dihy... gi\|190565763, gi... - gi\|190565763\|ref\|ZP_03018682.1\| dihydroorotase [Bacillus anthracis Tsiankovskii-I], gi\|190562682\|gb\|... PYRC_BACC0 - Dihydroorotase OS=Bacillus cereus (strain AH820) GN=pyrC PE=3 SV=1 gi\|30263891, gi\|... - gi\|30263891\|ref\|NP_846268.1\| dihydroorotase [Bacillus anthracis str. Ames], gi\|30258535\|gb\|AAP27754.... gi\|21401873, gi\|... - gi\|65321216\|ref\|ZP_00394175.1\| COG0044: Dihydroorotase and related cyclic amidohydrolases [Bacillus ... PYRC_BACAC - Dihydroorotase OS=Bacillus anthracis (strain CDC 684 / NRRL 3495) GN=pyrC PE=3 SV=1 PYRC_BACAA - Dihydroorotase OS=Bacillus anthracis (strain A0248) GN=pyrC PE=3 SV=1 gi\|254721421 - gi\|254721421\|ref\|ZP_05183210.1\| dihydroorotase [Bacillus anthracis str. A1055] gi\|167510936, gi... - gi\|167641156\|ref\|ZP_02399411.1\| dihydroorotase [Bacillus anthracis str. A0193], gi\|167510936\|gb\|EDR8... gi\|254735928 - gi\|254735928\|ref\|ZP_05193634.1\| dihydroorotase [Bacillus anthracis str. Western North America USA615... gi\|165872277, gi... - gi\|165872277\|ref\|ZP_02216914.1\| dihydroorotase [Bacillus anthracis str. A0488], gi\|164711953\|gb\|EDR1... gi\|254751014 - gi\|254751014\|ref\|ZP_05203053.1\| dihydroorotase [Bacillus anthracis str. Vollum] gi\|49186738, gi\|... - gi\|49186738\|ref\|YP_029990.1\| dihydroorotase [Bacillus anthracis str. Sterne], gi\|49180665\|gb\|AAT5604... gi\|172080423, gi... - gi\|177654912\|ref\|ZP_02936629.1\| dihydroorotase [Bacillus anthracis str. A0174], gi\|172080423\|gb\|EDT6... gi\|254756679 - gi\|254756679\|ref\|ZP_05208708.1\| dihydroorotase [Bacillus anthracis str. Australia 94] gi\|47504468, gi\|... - gi\|47529320\|ref\|YP_020669.1\| dihydroorotase [Bacillus anthracis str. 'Ames Ancestor'], gi\|47504468\|g... gi\|170126290, gi... - gi\|170708805\|ref\|ZP_02899241.1\| dihydroorotase [Bacillus anthracis str. A0389], gi\|170126290\|gb\|EDS9... PYRC_BACAN - Dihydroorotase OS=Bacillus anthracis GN=pyrC PE=1 SV=1	312.0	[0..2]	[422..3]
PYRC_BACWK - Dihydroorotase OS=Bacillus weihenstephanensis (strain KBAB4) GN=pyrC PE=3 SV=1	312.0	[0..2]	[422..3]
gi\|196047421, gi... - gi\|196047421\|ref\|ZP_03114633.1\| dihydroorotase [Bacillus cereus 03BB108], gi\|196021729\|gb\|EDX60424.1... PYRC_BACAH - Dihydroorotase OS=Bacillus thuringiensis (strain Al Hakam) GN=pyrC PE=3 SV=1 gi\|47553845, gi\|... - gi\|47569516\|ref\|ZP_00240196.1\| dihydroorotase [Bacillus cereus G9241], gi\|47553845\|gb\|EAL12216.1\| di... PYRC_BACCZ - Dihydroorotase OS=Bacillus cereus (strain ZK / E33L) GN=pyrC PE=3 SV=1 gi\|196030339, gi... - gi\|196038616\|ref\|ZP_03105924.1\| dihydroorotase [Bacillus cereus NVH0597-99], gi\|196030339\|gb\|EDX6893...	311.0	[0..2]	[422..3]
PYRC_BACHK - Dihydroorotase OS=Bacillus thuringiensis subsp. konkukian GN=pyrC PE=3 SV=1 PYRC_BACHK - Dihydroorotase OS=Bacillus thuringiensis subsp. konkukian (strain 97-27) GN=pyrC PE=3 SV=1	311.0	[0..2]	[422..3]

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Predicted Domain #1

Region A:
Residues: [1-426]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYVLKNGQVL NASGKLESKD VLIQNGKVNL IADSIEVTSG EEFDATGKLI TPGFIDVHVH  60
   61 LREPGGEHKE TILTGTKAAA RGGYTTICSM PNTKPVPDSK EVMESIQAKI KETAKVRVLP 120
  121 YASITTSLGT DELVDFEALK EAGAFAFTDD GVGVQLAGTM YEAMKRAAAL DMAIVAHCED 180
  181 NSLIYGGVVH DGIFAEKEGL KGIPNIAESV QIARDVLLAE AAGCHYHVCH ISTKESVRVV 240
  241 RDAKRAGIRV TAEVSPHHLI LDEEAIPGND GNWKMNPPLR SKEDRAALLE GLLDGTIDFI 300
  301 ATDHAPHAAE EKNVPMEQAA FGIVGLETAF PLLYTHFVKT NEWTLKQLID WMTVKPAECF 360
  361 KLPYGKLEEG SVADIVVLDL EKEANIDPDT FYSKGKNTPF VGETCIGWPV ATFAEGTLVY 420
  421 NEGEIK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.0
Match:	1xrfA
Description:	The Crystal Structure of a Novel, Latent Dihydroorotase from Aquifex aeolicus at 1.7 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uracil binding	2.6045173443981	bayes_pls_golite062009
pyrimidine binding	2.6045173443981	bayes_pls_golite062009
allantoinase activity	2.45571277189844	bayes_pls_golite062009
dihydroorotase activity	2.32070383330692	bayes_pls_golite062009
dihydropyrimidinase activity	2.27856136692645	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	2.20489529944693	bayes_pls_golite062009
hydrolase activity	2.17584977880576	bayes_pls_golite062009
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
adenine deaminase activity	1.4081199504179	bayes_pls_golite062009
thymine binding	1.34528530211689	bayes_pls_golite062009
AMP deaminase activity	0.8498975324894	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
binding	0.420164638111423	bayes_pls_golite062009
guanine deaminase activity	0.134430884998957	bayes_pls_golite062009
protein binding	0.0854348074331311	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: