YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16803591
Organism:	Listeria monocytogenes EGD-e
Length:	429 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16803591.

Description	E-value	Query Range	Subject Range
gi\|254824390 - gi\|254824390\|ref\|ZP_05229391.1\| Folyl-polyglutamate synthetase [Listeria monocytogenes FSL J1-194] gi\|225876614, gi... - gi\|226224152\|ref\|YP_002758259.1\| Folyl-polyglutamate synthetase [Listeria monocytogenes Clip81459], ... gi\|254878960 - gi\|254878960\|ref\|ZP_05251670.1\| Folyl-polyglutamate synthetase [Listeria monocytogenes FSL J2-071] gi\|254852175 - gi\|254852175\|ref\|ZP_05241523.1\| Folyl-polyglutamate synthetase [Listeria monocytogenes FSL R2-503] gi\|46881050, gi\|... - gi\|46907781\|ref\|YP_014170.1\| folylpolyglutamate synthase [Listeria monocytogenes str. 4b F2365], gi\|... gi\|255521287 - gi\|255521287\|ref\|ZP_05388524.1\| Folyl-polyglutamate synthetase [Listeria monocytogenes FSL J1-175] gi\|47093087, gi\|... - gi\|47093087\|ref\|ZP_00230864.1\| folylpolyglutamate synthase [Listeria monocytogenes str. 4b H7858], g... gi\|133735248, gi... - gi\|254931491\|ref\|ZP_05264850.1\| Folyl-polyglutamate synthetase [Listeria monocytogenes HPB2262], gi\|...	362.0	[0..1]	[429..1]
gi\|16800654 - gi\|16800654\|ref\|NP_470922.1\| hypothetical protein lin1586 [Listeria innocua Clip11262] gi\|25293648, gi\|... - pir\|\|AI1630 Folyl-polyglutamate synthetase homolog folC [imported] - Listeria innocua (strain Clip11...	349.0	[0..1]	[427..1]
gi\|42739523, gi\|... - gi\|42783594\|ref\|NP_980841.1\| folylpolyglutamate synthase [Bacillus cereus ATCC 10987], gi\|42739523\|g...	337.0	[0..3]	[427..2]
gi\|20807265, gi\|... - gi\|20807265\|ref\|NP_622436.1\| folylpolyglutamate synthase [Thermoanaerobacter tengcongensis MB4], gi\|... gi\|20807265 - gi\|20807265\|ref\|NP_622436.1\| Folylpolyglutamate synthase [Thermoanaerobacter tengcongensis MB4]	335.0	[0..1]	[425..1]
gi\|51974518, gi\|... - gi\|52141049\|ref\|YP_085780.1\| folylpolyglutamate synthase [Bacillus cereus E33L], gi\|51974518\|gb\|AAU1...	335.0	[0..3]	[427..2]
gi\|76795846, gi\|... - gi\|76795846\|ref\|ZP_00778217.1\| Folylpolyglutamate synthetase [Thermoanaerobacter ethanolicus ATCC 33... gi\|241903724, gi... - gi\|241903724\|ref\|ZP_04788443.1\| FolC bifunctional protein [Thermoanaerobacter brockii subsp. finnii ...	333.0	[0..5]	[426..2]
gi\|170708331, gi... - gi\|170708331\|ref\|ZP_02898775.1\| FolC bifunctional protein [Bacillus anthracis str. A0389], gi\|170126... gi\|177653963, gi... - gi\|177653963\|ref\|ZP_02936004.1\| FolC bifunctional protein [Bacillus anthracis str. A0174], gi\|172081... gi\|190567076, gi... - gi\|190567076\|ref\|ZP_03019992.1\| FolC bifunctional protein [Bacillus anthracis Tsiankovskii-I], gi\|19... gi\|49478641, gi\|... - gi\|49478641\|ref\|YP_038507.1\| folylpolyglutamate synthase [Bacillus thuringiensis serovar konkukian s... gi\|49187349, gi\|... - gi\|49187349\|ref\|YP_030601.1\| folylpolyglutamate synthase [Bacillus anthracis str. Sterne], gi\|491812... gi\|47529988, gi\|... - gi\|47529988\|ref\|YP_021337.1\| folylpolyglutamate synthase [Bacillus anthracis str. 'Ames Ancestor'], ... gi\|164712284, gi... - gi\|165871994\|ref\|ZP_02216635.1\| FolC bifunctional protein [Bacillus anthracis str. A0488], gi\|164712... gi\|167636210, gi... - gi\|167636210\|ref\|ZP_02394514.1\| FolC bifunctional protein [Bacillus anthracis str. A0442], gi\|167528... gi\|167511282, gi... - gi\|167640710\|ref\|ZP_02398970.1\| FolC bifunctional protein [Bacillus anthracis str. A0193], gi\|167511... gi\|170688681, gi... - gi\|170688681\|ref\|ZP_02879886.1\| FolC bifunctional protein [Bacillus anthracis str. A0465], gi\|170667... gi\|254757635 - gi\|254757635\|ref\|ZP_05209662.1\| dihydrofolate synthase/tetrahydrofolylpolyglutamate synthase [Bacill... gi\|30259183, gi\|... - gi\|30264525\|ref\|NP_846902.1\| folylpolyglutamate synthase [Bacillus anthracis str. Ames], gi\|30259183... gi\|254754803 - gi\|254754803\|ref\|ZP_05206838.1\| dihydrofolate synthase/tetrahydrofolylpolyglutamate synthase [Bacill... gi\|65321826, gi\|... - gi\|65321826\|ref\|ZP_00394785.1\| COG0285: Folylpolyglutamate synthase [Bacillus anthracis str. A2012],... gi\|254741599 - gi\|254741599\|ref\|ZP_05199286.1\| dihydrofolate synthase/tetrahydrofolylpolyglutamate synthase [Bacill... gi\|254736561 - gi\|254736561\|ref\|ZP_05194267.1\| dihydrofolate synthase/tetrahydrofolylpolyglutamate synthase [Bacill... gi\|254724615 - gi\|254724615\|ref\|ZP_05186398.1\| dihydrofolate synthase/tetrahydrofolylpolyglutamate synthase [Bacill... gi\|254687053 - gi\|254687053\|ref\|ZP_05150911.1\| dihydrofolate synthase/tetrahydrofolylpolyglutamate synthase [Bacill... gi\|229603858, gi... - gi\|229603858\|ref\|YP_002868741.1\| tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase [Bacil... gi\|228948171, gi... - gi\|228948171\|ref\|ZP_04110455.1\| Folyl-polyglutamate synthetase [Bacillus thuringiensis serovar monte... gi\|228830183, gi... - gi\|228929503\|ref\|ZP_04092523.1\| Folyl-polyglutamate synthetase [Bacillus thuringiensis serovar pondi... gi\|228917095, gi... - gi\|228917095\|ref\|ZP_04080653.1\| Folyl-polyglutamate synthetase [Bacillus thuringiensis serovar pulsi... gi\|227817237, gi... - gi\|227817237\|ref\|YP_002817246.1\| dihydrofolate synthase/tetrahydrofolylpolyglutamate synthase [Bacil...	332.0	[0..3]	[427..2]
gi\|242257906, gi... - gi\|242257906\|ref\|ZP_04802752.1\| FolC bifunctional protein [Thermoanaerobacter sp. X513], gi\|24223058... gi\|114804496, gi... - gi\|167040832\|ref\|YP_001663817.1\| FolC bifunctional protein [Thermoanaerobacter sp. X514], gi\|1668550...	330.0	[0..5]	[426..2]
gi\|47566647, gi\|... - gi\|47566647\|ref\|ZP_00237469.1\| FolC family protein [Bacillus cereus G9241], gi\|47556677\|gb\|EAL15009....	330.0	[0..3]	[427..2]
gi\|89156741, gi\|... - gi\|89205257\|ref\|ZP_01183828.1\| Folylpolyglutamate synthetase [Bacillus weihenstephanensis KBAB4], gi...	328.0	[0..3]	[427..2]

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Predicted Domain #1

Region A:
Residues: [1-429]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLNSYEEAL DWIHGTLRLG IKPGLARMEY MMEKLNHPEK ANKWVHIAGT NGKGSTLTFV  60
   61 RNALEEAGYK AGTFTSPYIE VFNERISVNG EPISDEMIVS LANRIKPIAE ELEKTVYGPP 120
  121 SEFEIITAMM FLCFADYVSI DIGIIEVGLG GRLDSTNILV PLVSVITTIG MDHMEFLGDT 180
  181 IEQIASEKAG IIKPGIPVVS GAIQKEAQEV IAEIATKNKS NVTQLNKAFS MHNENGNITY 240
  241 KTIYGEEISN LSIGLFGLHQ LNNAAVAIKV LQYLNTFSTF EIDLAAIRKG LEKAFWPGRM 300
  301 EKIISNPFIM LDGAHNPEGI KTFAHSVQKY PGPKKIIVSI LADKNYQEML AMLKSIPNAE 360
  361 IILTTFDYPR AMMAEEVIQI GKNEGISLNP DWQQALNNLY ETETNTKIFI TGSLYFISEV 420
  421 RKYLLASIR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.39794
Match:	1o5zA
Description:	Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at 2.10 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acid-amino acid ligase activity	4.03401034724886	bayes_pls_golite062009
tetrahydrofolylpolyglutamate synthase activity	3.94486215528378	bayes_pls_golite062009
ligase activity	3.80574681739772	bayes_pls_golite062009
catalytic activity	2.66037860982128	bayes_pls_golite062009
dihydrofolate synthase activity	2.50201834836027	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.96801058335544	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: