YRC Public Data Repository - Protein Structure Prediction

Protein:	HPRK_LACJO
Organism:	Lactobacillus johnsonii NCC 533
Length:	319 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HPRK_LACJO.

Description	E-value	Query Range	Subject Range
HPRK_LACGA - HPr kinase/phosphorylase OS=Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB ... gi\|23003221 - gi\|23003221\|ref\|ZP_00046888.1\| COG1493: Serine kinase of the HPr protein, regulates carbohydrate met... gi\|226820650 - gi\|226820650\|ref\|ZP_03809769.1\| HPr kinase/phosphorylase [Lactobacillus gasseri MV-22] gi\|238854080, gi... - gi\|238854080\|ref\|ZP_04644430.1\| HPr(Ser) kinase/phosphatase [Lactobacillus gasseri 202-4], gi\|238833...	436.0	[0..1]	[319..1]
gi\|227535584, gi... - gi\|227535584\|ref\|ZP_03965633.1\| HPr kinase [Lactobacillus paracasei subsp. paracasei ATCC 25302], gi... HPRK_LACCA - HPr kinase/phosphorylase OS=Lactobacillus casei GN=hprK PE=1 SV=1 HPRK_LACC3 - HPr kinase/phosphorylase OS=Lactobacillus casei (strain ATCC 334) GN=hprK PE=3 SV=1 gi\|224453415, gi... - gi\|239631201\|ref\|ZP_04674232.1\| HPr kinase/phosphorylase kinase/phosphorylase [Lactobacillus paracas... HPRK_LACCB - HPr kinase/phosphorylase OS=Lactobacillus casei (strain BL23) GN=hprK PE=3 SV=1 gi\|6688477 - gi\|6688477\|emb\|CAB65151.1\| HprK protein [Lactobacillus casei subsp. casei ATCC 393]	422.0	[0..1]	[317..1]
gi\|47569263, gi\|... - gi\|47569263\|ref\|ZP_00239948.1\| Hpr(ser) kinase/phosphatase [Bacillus cereus G9241], gi\|47554034\|gb\|E...	419.0	[0..2]	[312..46]
gi\|42740244, gi\|... - gi\|42784313\|ref\|NP_981560.1\| HPr kinase/phosphorylase [Bacillus cereus ATCC 10987], gi\|42740244\|gb\|A...	418.0	[0..2]	[312..44]
gi\|75759648, gi\|... - gi\|75759648\|ref\|ZP_00739732.1\| HPR(SER) KINASE / PHOSPHATASE [Bacillus thuringiensis serovar israel...	417.0	[0..2]	[312..44]
gi\|254997674 - gi\|254997674\|dbj\|BAH88275.1\| HPr(serine) kinase/phosphatase [Streptococcus mutans NN2025] HPRK_STRMU - HPr kinase/phosphorylase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) GN=hprK PE=... HPRK_STRMU - HPr kinase/phosphorylase OS=Streptococcus mutans GN=hprK PE=3 SV=1	415.0	[0..3]	[314..1]
gi\|228930162, gi... - gi\|228930162\|ref\|ZP_04093171.1\| HPr kinase/phosphorylase [Bacillus thuringiensis serovar pondicherie... gi\|228917766, gi... - gi\|228917766\|ref\|ZP_04081306.1\| HPr kinase/phosphorylase [Bacillus thuringiensis serovar pulsiensis ... gi\|228948879, gi... - gi\|228948879\|ref\|ZP_04111154.1\| HPr kinase/phosphorylase [Bacillus thuringiensis serovar monterrey B... gi\|228936446, gi... - gi\|228936446\|ref\|ZP_04099244.1\| HPr kinase/phosphorylase [Bacillus thuringiensis serovar andalousien... gi\|228596075, gi... - gi\|229187371\|ref\|ZP_04314514.1\| HPr kinase/phosphorylase [Bacillus cereus BGSC 6E1], gi\|228596075\|gb... gi\|228658762, gi... - gi\|229124667\|ref\|ZP_04253848.1\| HPr kinase/phosphorylase [Bacillus cereus 95/8201], gi\|228658762\|gb\|... gi\|65317134 - gi\|65317134\|ref\|ZP_00390093.1\| COG1493: Serine kinase of the HPr protein, regulates carbohydrate met...	414.0	[0..2]	[312..26]
HPRK_LISMO - HPr kinase/phosphorylase OS=Listeria monocytogenes GN=hprK PE=3 SV=1 gi\|47015536, gi\|... - gi\|47096075\|ref\|ZP_00233676.1\| HPr(Ser) kinase/phosphatase [Listeria monocytogenes str. 1/2a F6854],... gi\|224503276 - gi\|224503276\|ref\|ZP_03671583.1\| HPr kinase/phosphorylase [Listeria monocytogenes FSL R2-561] gi\|47018857, gi\|... - gi\|47092769\|ref\|ZP_00230554.1\| HPr(Ser) kinase/phosphatase [Listeria monocytogenes str. 4b H7858], g... gi\|224499840 - gi\|224499840\|ref\|ZP_03668189.1\| HPr kinase/phosphorylase [Listeria monocytogenes Finland 1988] HPRK_LISMF - HPr kinase/phosphorylase OS=Listeria monocytogenes serotype 4b (strain F2365) GN=hprK PE=3 SV=1 HPRK_LISMO - HPr kinase/phosphorylase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=hpr... gi\|126942452, gi... - gi\|254900379\|ref\|ZP_05260303.1\| HPr kinase/phosphorylase [Listeria monocytogenes J0161], gi\|15318494... gi\|153197211, gi... - gi\|254831094\|ref\|ZP_05235749.1\| HPr kinase/phosphorylase [Listeria monocytogenes 10403S], gi\|1531972... gi\|254913382, gi... - gi\|254913382\|ref\|ZP_05263394.1\| HPr kinase/phosphorylase [Listeria monocytogenes J2818], gi\|15319214... gi\|153168591, gi... - gi\|254872173\|ref\|ZP_05244883.1\| HPr kinase/phosphorylase [Listeria monocytogenes FSL N1-017], gi\|153... gi\|153175735, gi... - gi\|254828058\|ref\|ZP_05232745.1\| HPr kinase/phosphorylase [Listeria monocytogenes FSL N3-165], gi\|153... gi\|254937763, gi... - gi\|254937763\|ref\|ZP_05269460.1\| HPr kinase/phosphorylase [Listeria monocytogenes F6900], gi\|15318057... HPRK_LISMH - HPr kinase/phosphorylase OS=Listeria monocytogenes serotype 4a (strain HCC23) GN=hprK PE=3 SV=1 gi\|153204054, gi... - gi\|254932276\|ref\|ZP_05265635.1\| HPr kinase/phosphorylase [Listeria monocytogenes HPB2262], gi\|153204... HPRK_LISMC - HPr kinase/phosphorylase OS=Listeria monocytogenes serotype 4b (strain Clip81459) GN=hprK PE=3 SV=1 gi\|254853515 - gi\|254853515\|ref\|ZP_05242863.1\| HPr kinase/phosphorylase [Listeria monocytogenes FSL R2-503] gi\|254879191 - gi\|254879191\|ref\|ZP_05251901.1\| HPr kinase/phosphorylase [Listeria monocytogenes FSL J2-071] gi\|254992085 - gi\|254992085\|ref\|ZP_05274275.1\| HPr kinase/phosphorylase [Listeria monocytogenes FSL J2-064] gi\|255027005 - gi\|255027005\|ref\|ZP_05298991.1\| HPr kinase/phosphorylase [Listeria monocytogenes FSL J2-003] HPRK_LISMC - HPr kinase/phosphorylase OS=Listeria monocytogenes serotype 4b (strain CLIP80459) GN=hprK PE=3 SV=1 gi\|255521862 - gi\|255521862\|ref\|ZP_05389099.1\| HPr kinase/phosphorylase [Listeria monocytogenes FSL J1-175]	414.0	[0..1]	[314..1]
HPRK_LACPL - HPr kinase/phosphorylase OS=Lactobacillus plantarum GN=hprK PE=3 SV=1 HPRK_LACPL - HPr kinase/phosphorylase OS=Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) GN=hp... gi\|254044718, gi... - gi\|254555791\|ref\|YP_003062208.1\| HPr kinase/phosphorylase [Lactobacillus plantarum JDM1], gi\|2540447...	414.0	[0..1]	[313..1]
HPRK_LISIN - HPr kinase/phosphorylase OS=Listeria innocua GN=hprK PE=3 SV=1 HPRK_LISIN - HPr kinase/phosphorylase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=hprK PE=3 SV=1	412.0	[0..1]	[314..1]

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Predicted Domain #1

Region A:
Residues: [1-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEAVKVSEL VKDLPSLRVV EGKEYLDQKL INTSDISRPG LELTGYFDFY PKNRIQLLGR  60
   61 TEISYSARLD HDLRERVFNK MATPETPCFI VSRGLPIPSE MLEAAEKEKI PVLSSNMATT 120
  121 HLSSVITQFL DEKLAPRKSI HGVLVEIYGM GVLIIGNSGV GKSETALDLV KRGHRLIADD 180
  181 RVDVYQKDDK TVVGEAPKIL KHLMEIRGIG IIDVMNLFGA GAVKDSTEIQ LIICLQNWDP 240
  241 KANYDRLGFN EKTREIFEVD VPQVTVPVKV GRNLAIIIEV AAMNFRAKKM GYDASQKFEQ 300
  301 NLTELISDNS KKDEGDSRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	106.0
Match:	1ko7A
Description:	HPr kinase/phoshatase HprK N-terminal domain; HPr kinase HprK C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.96595957357027	bayes_pls_golite062009
phosphoenolpyruvate carboxykinase activity	0.895807668315489	bayes_pls_golite062009
carbon-carbon lyase activity	0.626079896377643	bayes_pls_golite062009
lyase activity	0.600389586904626	bayes_pls_golite062009
carboxy-lyase activity	0.593189334075365	bayes_pls_golite062009
binding	0.456582751079595	bayes_pls_golite062009
phosphoenolpyruvate carboxykinase (ATP) activity	0.0272102212862302	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: