YRC Public Data Repository - Protein Structure Prediction

Protein:	EG12712
Organism:	Escherichia coli str. K-12 substr. MG1655
Length:	171 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG12712.

Description	E-value	Query Range	Subject Range
LUXS_VIBPA - S-ribosylhomocysteine lyase OS=Vibrio parahaemolyticus GN=luxS PE=3 SV=1 LUXS_VIBPA - S-ribosylhomocysteine lyase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=luxS ... gi\|153838707, gi... - gi\|153838707\|ref\|ZP_01991374.1\| S-Ribosylhomocysteinase (LuxS) [Vibrio parahaemolyticus AQ3810], gi\|...	319.0	[0..1]	[171..1]
LUXS_VIBAL - S-ribosylhomocysteine lyase OS=Vibrio alginolyticus GN=luxS PE=3 SV=1	318.0	[0..1]	[171..1]
LUXS_ECOL5 - S-ribosylhomocysteine lyase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=luxS PE=3 SV=1 gi\|227834865, gi... - gi\|227888225\|ref\|ZP_04006030.1\| S-ribosylhomocysteine lyase [Escherichia coli 83972], gi\|227834865\|g... LUXS_ECOL6 - S-ribosylhomocysteine lyase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=luxS P... LUXS_ECOL6 - S-ribosylhomocysteine lyase OS=Escherichia coli O6 GN=luxS PE=3 SV=3 LUXS_ECOSM - S-ribosylhomocysteine lyase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=luxS PE=3 SV=1 gi\|190908361, gi... - gi\|75241635\|ref\|ZP_00725472.1\| COG1854: LuxS protein involved in autoinducer AI2 synthesis [Escheric... LUXS_ECO81 - S-ribosylhomocysteine lyase OS=Escherichia coli O81 (strain ED1a) GN=luxS PE=3 SV=1	317.0	[0..1]	[171..1]
LUXS_ECOSE - S-ribosylhomocysteine lyase OS=Escherichia coli (strain SE11) GN=luxS PE=3 SV=1 LUXS_ECO8A - S-ribosylhomocysteine lyase OS=Escherichia coli O8 (strain IAI1) GN=luxS PE=3 SV=1 gi\|75255951, gi\|... - gi\|75255951\|ref\|ZP_00727675.1\| COG1854: LuxS protein involved in autoinducer AI2 synthesis [Escheric... gi\|191167092, gi... - gi\|75229767\|ref\|ZP_00716297.1\| COG1854: LuxS protein involved in autoinducer AI2 synthesis [Escheric... gi\|194414149, gi... - gi\|75210891\|ref\|ZP_00711015.1\| COG1854: LuxS protein involved in autoinducer AI2 synthesis [Escheric... LUXS_ECO55 - S-ribosylhomocysteine lyase OS=Escherichia coli (strain 55989 / EAEC) GN=luxS PE=3 SV=1	317.0	[0..1]	[171..1]
gi\|116183744, gi... - gi\|75854253\|ref\|ZP_00761958.1\| COG1854: LuxS protein involved in autoinducer AI2 synthesis [Vibrio s...	316.0	[0..1]	[171..1]
LUXS_ECO57 - S-ribosylhomocysteine lyase OS=Escherichia coli O157:H7 GN=luxS PE=3 SV=3 gi\|209762142, gi... - pir\|\|H85916 autoinducer production protein LuxS - Escherichia coli (strain O157:H7, substrain EDL93... gi\|254594033, gi... - gi\|254794633\|ref\|YP_003079470.1\| S-ribosylhomocysteine lyase [Escherichia coli O157:H7 str. TW14359]... gi\|12517128, gi\|... - gi\|15803206\|ref\|NP_289238.1\| S-ribosylhomocysteinase [Escherichia coli O157:H7 EDL933], gi\|12517128\|... LUXS_ECO5E - S-ribosylhomocysteine lyase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=luxS PE=3 SV=1 gi\|217319995, gi... - gi\|217327628\|ref\|ZP_03443711.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. TW14588], gi\|... gi\|15832803, gi\|... - gi\|15832803\|ref\|NP_311576.1\| S-ribosylhomocysteinase [Escherichia coli O157:H7 str. Sakai], gi\|13363... gi\|195938440 - gi\|195938440\|ref\|ZP_03083822.1\| S-ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4024] gi\|208728575, gi... - gi\|208808774\|ref\|ZP_03251111.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4206], gi\|2... gi\|208813163, gi... - gi\|208813163\|ref\|ZP_03254492.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4045], gi\|2... gi\|208740806, gi... - gi\|208820683\|ref\|ZP_03261003.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4042], gi\|2... gi\|187769595, gi... - gi\|187769595\|gb\|EDU33439.1\| S-Ribosylhomocysteinase (LuxS) [Escherichia coli O157:H7 str. EC4196], g... gi\|168778669, gi... - gi\|189003476\|gb\|EDU72462.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4076], gi\|16877... gi\|168787942, gi... - gi\|189372164\|gb\|EDU90580.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC869], gi\|168787... gi\|189377202, gi... - gi\|189377202\|gb\|EDU95618.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC508], gi\|168800... gi\|168750930, gi... - gi\|188014984\|gb\|EDU53106.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4113], gi\|16875... gi\|189357367, gi... - gi\|189357367\|gb\|EDU75786.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4401], gi\|16875... gi\|189367270, gi... - gi\|189367270\|gb\|EDU85686.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4501], gi\|16876... gi\|189362156, gi... - gi\|189362156\|gb\|EDU80575.1\| S-Ribosylhomocysteinase [Escherichia coli O157:H7 str. EC4486], gi\|16876...	316.0	[0..1]	[171..1]
gi\|188487800, gi... - gi\|75513257\|ref\|ZP_00735699.1\| COG1854: LuxS protein involved in autoinducer AI2 synthesis [Escheric...	315.0	[0..1]	[171..1]
LUXS_YERE8 - S-ribosylhomocysteine lyase OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 ... gi\|238717198, gi... - gi\|77960441\|ref\|ZP_00824312.1\| COG1854: LuxS protein involved in autoinducer AI2 synthesis [Yersinia...	315.0	[0..1]	[171..1]
gi\|238713261, gi... - gi\|77956708\|ref\|ZP_00820790.1\| COG1854: LuxS protein involved in autoinducer AI2 synthesis [Yersinia...	315.0	[0..1]	[171..1]
LUXS_SHIF8 - S-ribosylhomocysteine lyase OS=Shigella flexneri serotype 5b (strain 8401) GN=luxS PE=3 SV=1 LUXS_SHIB3 - S-ribosylhomocysteine lyase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=luxS PE=3... LUXS_SHIBS - S-ribosylhomocysteine lyase OS=Shigella boydii serotype 4 (strain Sb227) GN=luxS PE=3 SV=1	314.0	[0..1]	[171..1]

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Predicted Domain #1

Region A:
Residues: [1-171]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLLDSFTVD HTRMEAPAVR VAKTMNTPHG DAITVFDLRF CVPNKEVMPE RGIHTLEHLF  60
   61 AGFMRNHLNG NGVEIIDISP MGCRTGFYMS LIGTPDEQRV ADAWKAAMED VLKVQDQNQI 120
  121 PELNVYQCGT YQMHSLQEAQ DIARSILERD VRINSNEELA LPKEKLQELH I

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.522879
Match:	1j6wA
Description:	Autoinducer-2 production protein LuxS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-ribosylhomocysteine lyase activity	1.74759627448878	bayes_pls_golite062009
quorum sensing signal generator activity	1.39649645139585	bayes_pls_golite062009
quorum sensing response regulator activity	1.39649645139585	bayes_pls_golite062009
catalytic activity	0.00996887145100289	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: