YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|255096000
Organism:	Mycobacterium tuberculosis KZN 605
Length:	257 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|255096000.

Description	E-value	Query Range	Subject Range
gi\|196253313, gi... - gi\|196253313\|ref\|ZP_03151946.1\| RNA polymerase, sigma-24 subunit, ECF subfamily [Clostridium thermoc... gi\|67849833, gi\|... - gi\|67916230\|ref\|ZP_00509948.1\| Sigma-70 region 2:Sigma-70 region 4 [Clostridium thermocellum ATCC 27...	177.0	[0..67]	[245..3]
gi\|25323335, gi\|... - pir\|\|F87043 ECF subfamily sigma subunit [imported] - Mycobacterium leprae, gi\|13093076\|emb\|CAC31457.... gi\|15827526 - gi\|15827526\|ref\|NP_301789.1\| RNA polymerase sigma factor SigE [Mycobacterium leprae TN] gi\|221230003, gi... - gi\|221230003\|ref\|YP_002503419.1\| ECF subfamily sigma subunit [Mycobacterium leprae Br4923], gi\|21993...	175.0	[0..5]	[257..10]
gi\|221312309 - gi\|221312309\|ref\|ZP_03594114.1\| RNA polymerase sigma factor SigW [Bacillus subtilis subsp. subtilis ... gi\|221317242 - gi\|221317242\|ref\|ZP_03598536.1\| RNA polymerase sigma factor SigW [Bacillus subtilis subsp. subtilis ... gi\|221321505 - gi\|221321505\|ref\|ZP_03602799.1\| RNA polymerase sigma factor SigW [Bacillus subtilis subsp. subtilis ... SIGW_BACSU - RNA polymerase sigma factor sigW OS=Bacillus subtilis GN=sigW PE=2 SV=1 SIGW_BACSU - ECF RNA polymerase sigma factor SigW OS=Bacillus subtilis (strain 168) GN=sigW PE=1 SV=1	169.0	[0..73]	[242..9]
gi\|89160528, gi\|... - gi\|89209876\|ref\|ZP_01188270.1\| Sigma-70 region 2:Sigma-70 region 4 [Halothermothrix orenii H 168], g...	167.0	[0..64]	[247..1]
gi\|150390876, gi... - gi\|77685958\|ref\|ZP_00801335.1\| Sigma-70 region 2:Sigma-70 region 4 [Alkaliphilus metalliredigenes QY...	167.0	[0..67]	[243..6]
gi\|158140438, gi... - gi\|158320239\|ref\|YP_001512746.1\| ECF subfamily RNA polymerase sigma-24 factor [Alkaliphilus oremland...	166.0	[0..69]	[246..5]
gi\|2062634 - gi\|2062634\|gb\|AAC45219.1\| extracytoplasmic function alternative sigma factor [Mycobacterium avium] gi\|41408655, gi\|... - gi\|41408655\|ref\|NP_961491.1\| RNA polymerase sigma factor SigE [Mycobacterium avium subsp. paratuberc...	165.0	[0..5]	[254..4]
gi\|92431764, gi\|... - gi\|92910591\|ref\|ZP_01279366.1\| Sigma-70 region 2:Sigma-70 region 4 [Mycobacterium sp. JLS], gi\|92431...	165.0	[0..1]	[251..1]
gi\|89085777, gi\|... - gi\|89099391\|ref\|ZP_01172267.1\| RNA polymerase sigma-70 factor [Bacillus sp. NRRL B-14911], gi\|890857...	165.0	[0..73]	[241..9]
gi\|88923028, gi\|... - gi\|88947512\|ref\|ZP_01150491.1\| RNA polymerase ECF-type sigma factor [Desulfotomaculum reducens MI-1]...	162.0	[0..66]	[254..2]

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Predicted Domain #1

Region A:
Residues: [1-257]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELLGGPRVG NTESQLCVAD GDDLPTYCSA NSEDLNITTI TTLSPTSMSH PQQVRDDQWV  60
   61 EPSDQLQGTA VFDATGDKAT MPSWDELVRQ HADRVYRLAY RLSGNQHDAE DLTQETFIRV 120
  121 FRSVQNYQPG TFEGWLHRIT TNLFLDMVRR RARIRMEALP EDYDRVPADE PNPEQIYHDA 180
  181 RLGPDLQAAL ASLPPEFRAA VVLCDIEGLS YEEIGATLGV KLGTVRSRIH RGRQALRDYL 240
  241 AAHPEHGECA VHVNPVR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.69897
Match:	1or7A
Description:	SigmaE factor (RpoE)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription initiation factor activity	5.71806750193815	bayes_pls_golite062009
sigma factor activity	5.58029806879061	bayes_pls_golite062009
transcription regulator activity	3.67872017549582	bayes_pls_golite062009
binding	1.02634976114785	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: