YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|227081312, gi...
Organism:	Vibrio cholerae M66-2
Length:	210 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|227081312, gi....

Description	E-value	Query Range	Subject Range
gi\|116220453, gi... - gi\|75819710\|ref\|ZP_00749778.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Vibrio cholerae V51], gi\|...	308.0	[0..1]	[210..1]
tr\|D7H7Y7\|D7H7Y7... - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio cholerae RC385 GN=hisI PE=3 SV=1 gi\|254223617, gi... - gi\|75823475\|ref\|ZP_00752973.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Vibrio cholerae RC385], g...	308.0	[0..1]	[210..1]
HIS2_VIBVY - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio vulnificus (strain YJ016) GN=hisI PE=3 S...	294.0	[0..3]	[210..4]
HIS2_VIBVU - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio vulnificus GN=hisI PE=3 SV=1 HIS2_VIBVU - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio vulnificus (strain CMCP6) GN=hisI PE=3 S...	292.0	[0..3]	[210..4]
gi\|153838271, gi... - gi\|153838271\|ref\|ZP_01990938.1\| histidine biosynthesis bifunctional protein hisIE [Vibrio parahaemol... HIS2_VIBPA - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio parahaemolyticus GN=hisI PE=3 SV=1 HIS2_VIBPA - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio parahaemolyticus serotype O3:K6 (strain ...	292.0	[0..3]	[210..4]
gi\|91226024, gi\|... - gi\|91226024\|ref\|ZP_01260951.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyr...	291.0	[0..3]	[210..4]
gi\|84376461, gi\|... - gi\|84391748\|ref\|ZP_00991650.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyr...	290.0	[0..2]	[210..4]
gi\|59479727, gi\|... - gi\|59711626\|ref\|YP_204402.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrop...	288.0	[0..6]	[210..2]
gi\|85835153, gi\|... - gi\|86147088\|ref\|ZP_01065405.1\| bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyr...	288.0	[0..9]	[210..15]
gi\|75854234, gi\|... - gi\|75854234\|ref\|ZP_00761940.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Vibrio sp. Ex25], gi\|2542...	288.0	[0..3]	[210..4]

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Predicted Domain #1

Region A:
Residues: [1-117]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPASPFATL TDRIDWQKVD GLVPAIVQDF QSSQVLMMGY MNPEALQKTL DTQQVTFFSR  60
   61 SKQRLWTKGE TSGHVLQLKN IALDCDQDTL LVKVNPIGPT CHTGTVTCWD GDAQEES

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.09691
Match:	1zpsA
Description:	Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosyl-AMP cyclohydrolase activity	4.150200144507	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	2.23740731288751	bayes_pls_golite062009
catalytic activity	1.39985329737364	bayes_pls_golite062009
cyclohydrolase activity	0.79104127517031	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.54834173729282	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [118-210]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMVWLHQLEQ LLAERKNADP SSSYTASLYA RGTKRIAQKV GEEGVEVALA ATAGDKEELI  60
   61 CESADLMYHL LVLLQEQGLA MNDVINKLKE RHK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.522879
Match:	1yvwA
Description:	Crystal structure of Phosphoribosyl-ATP pyrophosphohydrolase from Bacillus cereus. NESGC target BcR13.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosyl-ATP diphosphatase activity	3.7001994388833	bayes_pls_golite062009
phosphoribosyl-AMP cyclohydrolase activity	2.61820126109961	bayes_pls_golite062009
catalytic activity	1.00486703080234	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.72725441841528	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: