YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRC_BACAA
Organism:	Bacillus anthracis str. A0248
Length:	428 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRC_BACAA.

Description	E-value	Query Range	Subject Range
gi\|196253633, gi... - gi\|196253633\|ref\|ZP_03152251.1\| dihydroorotase, multifunctional complex type [Clostridium thermocell... gi\|67876353, gi\|... - gi\|67876353\|ref\|ZP_00505240.1\| Dihydroorotase multifunctional complex type [Clostridium thermocellum...	1.0E-85	[1..427]	[1..428]
PYRC_BACWK - Dihydroorotase OS=Bacillus weihenstephanensis (strain KBAB4) GN=pyrC PE=3 SV=1	1.0E-83	[1..428]	[1..428]
PYRC_BACC1 - Dihydroorotase OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=pyrC PE=3 SV=1	1.0E-83	[1..428]	[1..428]
gi\|196047421, gi... - gi\|196047421\|ref\|ZP_03114633.1\| dihydroorotase [Bacillus cereus 03BB108], gi\|196021729\|gb\|EDX60424.1... PYRC_BACAH - Dihydroorotase OS=Bacillus thuringiensis (strain Al Hakam) GN=pyrC PE=3 SV=1 gi\|47553845, gi\|... - gi\|47569516\|ref\|ZP_00240196.1\| dihydroorotase [Bacillus cereus G9241], gi\|47553845\|gb\|EAL12216.1\| di... PYRC_BACCZ - Dihydroorotase OS=Bacillus cereus (strain ZK / E33L) GN=pyrC PE=3 SV=1 gi\|196030339, gi... - gi\|196038616\|ref\|ZP_03105924.1\| dihydroorotase [Bacillus cereus NVH0597-99], gi\|196030339\|gb\|EDX6893...	1.0E-83	[1..428]	[1..428]
PYRC_BACHK - Dihydroorotase OS=Bacillus thuringiensis subsp. konkukian GN=pyrC PE=3 SV=1 PYRC_BACHK - Dihydroorotase OS=Bacillus thuringiensis subsp. konkukian (strain 97-27) GN=pyrC PE=3 SV=1	1.0E-83	[1..428]	[1..428]
PYRC_GEOUR - Dihydroorotase OS=Geobacter uraniireducens (strain Rf4) GN=pyrC PE=3 SV=1	2.0E-83	[1..422]	[1..423]
PYRC_BACCR - Dihydroorotase OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 /...	2.0E-83	[1..428]	[1..428]
gi\|89098723, gi\|... - gi\|89098723\|ref\|ZP_01171605.1\| dihydroorotase [Bacillus sp. NRRL B-14911], gi\|89086685\|gb\|EAR65804.1...	3.0E-82	[1..426]	[1..426]
gi\|78222979, gi\|... - gi\|78222979\|ref\|YP_384726.1\| dihydroorotase [Geobacter metallireducens GS-15], gi\|78194234\|gb\|ABB320...	4.0E-82	[4..423]	[2..422]
gi\|114566809, gi... - gi\|71541213\|ref\|ZP_00663007.1\| Dihydroorotase multifunctional complex type [Syntrophomonas wolfei st...	1.0E-81	[1..428]	[1..429]

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Predicted Domain #1

Region A:
Residues: [1-428]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYLFKNGRY MNEEGKIVAT DLLVQDGKIA KVAENITADN AEVIDVNGKL IAPGLVDVHV  60
   61 HLREPGGEHK ETIETGTLAA AKGGFTTICA MPNTRPVPDC REHMEDLQNR IKEKAHVNVL 120
  121 PYGAITVRQA GSEMTDFETL KELGAFAFTD DGVGVQDASM MLAAMKRAAK LNMAVVAHCE 180
  181 ENTLINKGCV HEGKFSEKHG LNGIPSVCES VHIARDILLA EAADCHYHVC HVSTKGSVRV 240
  241 IRDAKRAGIK VTAEVTPHHL VLCEDDIPSA DPNFKMNPPL RGKEDHEALI EGLLDGTIDM 300
  301 IATDHAPHTA EEKAQGIERA PFGITGFETA FPLLYTNLVK KGIITLEQLI QFLTEKPADT 360
  361 FGLEAGRLKE GRTADITIID LEQEEEIDPT TFLSKGKNTP FAGWKCQGWP VMTIVGGKIA 420
  421 WQKESALV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.522879
Match:	1xrfA
Description:	The Crystal Structure of a Novel, Latent Dihydroorotase from Aquifex aeolicus at 1.7 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uracil binding	2.6045173443981	bayes_pls_golite062009
pyrimidine binding	2.6045173443981	bayes_pls_golite062009
allantoinase activity	2.45571277189844	bayes_pls_golite062009
dihydroorotase activity	2.32070383330692	bayes_pls_golite062009
dihydropyrimidinase activity	2.27856136692645	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	2.20489529944693	bayes_pls_golite062009
hydrolase activity	2.17584977880576	bayes_pls_golite062009
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
adenine deaminase activity	1.4081199504179	bayes_pls_golite062009
thymine binding	1.34528530211689	bayes_pls_golite062009
AMP deaminase activity	0.8498975324894	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
binding	0.420164638111423	bayes_pls_golite062009
guanine deaminase activity	0.134430884998957	bayes_pls_golite062009
protein binding	0.0854348074331311	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: