YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|229603342, gi...
Organism:	Bacillus anthracis str. A0248
Length:	258 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|229603342, gi....

Description	E-value	Query Range	Subject Range
gi\|29895119, gi\|... - gi\|30019575\|ref\|NP_831206.1\| uroporphyrin-III C-methyltransferase [Bacillus cereus ATCC 14579], gi\|2... gi\|229043267, gi... - gi\|229043267\|ref\|ZP_04190989.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus AH676], gi... gi\|229144126, gi... - gi\|229144126\|ref\|ZP_04272541.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus BDRD-ST24]... gi\|229126841, gi... - gi\|229126841\|ref\|ZP_04255853.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus BDRD-Cer4]... gi\|228674452, gi... - gi\|229108983\|ref\|ZP_04238584.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus Rock1-15],...	8.0E-80	[1..258]	[2..259]
gi\|42736543, gi\|... - gi\|42780623\|ref\|NP_977870.1\| uroporphyrin-III C-methyltransferase [Bacillus cereus ATCC 10987], gi\|4...	2.0E-79	[1..258]	[1..258]
gi\|51977390, gi\|... - gi\|52143921\|ref\|YP_082908.1\| uroporphyrin-III C-methyltransferase [Bacillus cereus E33L], gi\|5197739...	3.0E-79	[1..258]	[1..258]
gi\|47566316, gi\|... - gi\|47566316\|ref\|ZP_00237344.1\| uroporphyrin-III C-methyltransferase [Bacillus cereus G9241], gi\|4755...	4.0E-79	[1..258]	[1..258]
gi\|75760415, gi\|... - gi\|75760415\|ref\|ZP_00740458.1\| Uroporphyrin-III C-methyltransferase [Bacillus thuringiensis serovar ...	5.0E-79	[1..258]	[2..259]
gi\|228651038, gi... - gi\|229132332\|ref\|ZP_04261186.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus BDRD-ST196... gi\|89154233, gi\|... - gi\|89207808\|ref\|ZP_01186339.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Bacillus weihenstep...	9.0E-79	[1..258]	[1..258]
gi\|40642724 - gi\|40642724\|emb\|CAD48921.1\| uroporphyrinogen III methyltransferase [Bacillus megaterium]	6.0E-76	[1..255]	[1..255]
gi\|196158491, gi... - gi\|88794338\|ref\|ZP_01110047.1\| uroporphyrin-III C-methyltransferase [Alteromonas macleodii 'Deep eco...	9.0E-75	[2..246]	[236..479]
gi\|27316645, gi\|... - gi\|27469096\|ref\|NP_765733.1\| uroporphyrin-III C-methyltransferase [Staphylococcus epidermidis ATCC 1...	6.0E-74	[1..244]	[4..245]
gi\|89202133, gi\|... - gi\|89202133\|ref\|ZP_01180863.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Bacillus cereus sub...	6.0E-74	[2..258]	[6..262]

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Predicted Domain #1

Region A:
Residues: [1-258]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKVYIVGAG PGDPDLITVK GLKCIEKADV ILYDRLVNKE LLSYAKPEAD LIYCGKLPNY  60
   61 HTMKQETINT FLIKYAKKGK IVTRLKGGDP FVFGRGGEEA EALAKQGVPF EIVPGISAGI 120
  121 AAPAYAGIPV THRDASASFA IVTGHRKEDA AEEVKWGNLA KGVETLAVYM GVSNLPYICE 180
  181 QLMKHGKDKS TPAAIIERGT TSMQRTVVGT LGTIVDVAKK EQIQNPSMIV IGEVVRFREK 240
  241 IHWFEKQTES TYQVSGVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.045757
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.573271502205	bayes_pls_golite062009
C-methyltransferase activity	3.35393353163232	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.18371138649366	bayes_pls_golite062009
catalytic activity	1.48349578618275	bayes_pls_golite062009
transferase activity	0.912524944496351	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.431791521097299	bayes_pls_golite062009
methyltransferase activity	0.424918406685891	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.28351517300952	bayes_pls_golite062009
uroporphyrinogen-III synthase activity	0.00871858903098705	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: