YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|254724615
Organism:	Bacillus anthracis str. A1055
Length:	433 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|254724615.

Description	E-value	Query Range	Subject Range
gi\|42739523, gi\|... - gi\|42783594\|ref\|NP_980841.1\| folylpolyglutamate synthase [Bacillus cereus ATCC 10987], gi\|42739523\|g...	2.0E-99	[1..433]	[1..433]
gi\|51974518, gi\|... - gi\|52141049\|ref\|YP_085780.1\| folylpolyglutamate synthase [Bacillus cereus E33L], gi\|51974518\|gb\|AAU1...	2.0E-99	[1..433]	[1..433]
gi\|47566647, gi\|... - gi\|47566647\|ref\|ZP_00237469.1\| FolC family protein [Bacillus cereus G9241], gi\|47556677\|gb\|EAL15009....	5.0E-98	[1..433]	[1..433]
gi\|89156741, gi\|... - gi\|89205257\|ref\|ZP_01183828.1\| Folylpolyglutamate synthetase [Bacillus weihenstephanensis KBAB4], gi...	4.0E-96	[1..433]	[1..433]
gi\|30022545, gi\|... - gi\|30022545\|ref\|NP_834176.1\| folylpolyglutamate synthase [Bacillus cereus ATCC 14579], gi\|29898103\|g...	5.0E-96	[1..433]	[1..433]
gi\|75759955, gi\|... - gi\|75759955\|ref\|ZP_00740024.1\| Folylpolyglutamate synthase / Dihydrofolate synthase [Bacillus thuri...	1.0E-95	[2..433]	[11..442]
gi\|152025626, gi... - gi\|89200301\|ref\|ZP_01179055.1\| Folylpolyglutamate synthetase [Bacillus cereus subsp. cytotoxis NVH 3...	1.0E-94	[1..433]	[1..433]
gi\|56381014, gi\|... - gi\|56421172\|ref\|YP_148490.1\| folyl-polyglutamate synthetase [Geobacillus kaustophilus HTA426], gi\|56...	9.0E-92	[1..433]	[1..433]
FOLC_BACSU - Folylpolyglutamate synthase OS=Bacillus subtilis GN=folC PE=3 SV=2 gi\|221324274 - gi\|221324274\|ref\|ZP_03605568.1\| folyl-polyglutamate synthetase [Bacillus subtilis subsp. subtilis st... gi\|221319992 - gi\|221319992\|ref\|ZP_03601286.1\| folyl-polyglutamate synthetase [Bacillus subtilis subsp. subtilis st... gi\|221315073 - gi\|221315073\|ref\|ZP_03596878.1\| folyl-polyglutamate synthetase [Bacillus subtilis subsp. subtilis st... FOLC_BACSU - Folylpolyglutamate synthase OS=Bacillus subtilis (strain 168) GN=folC PE=3 SV=2	7.0E-90	[1..430]	[1..430]
gi\|89086351, gi\|... - gi\|89098947\|ref\|ZP_01171827.1\| folyl-polyglutamate synthetase [Bacillus sp. NRRL B-14911], gi\|890863...	5.0E-88	[1..429]	[11..439]

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Predicted Domain #1

Region A:
Residues: [1-433]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIHTYEEAIG WIHSRLKFGI KPGLERMRWM LEELGNPERH IKCVHLAGTN GKGSTLTYMR  60
   61 YMLEDAKYKV GTFTSPYIET FNERISVNGT PIADEEITEL VKMVKPVVEK LDETDLGEAT 120
  121 EFEIITVMAI CYFGKVNFCD VVLFETGLGG RFDSTNVIHP VLTIITNIGH DHMHILGNTL 180
  181 GEIAYEKAGI IKSGVPVITG VQDEEALQVI QKVAKENRAN LYEMGNHFTA LHKQSSENGE 240
  241 QFDFTCPFAS FEDVRIAMKG SHQVGNAALA LMAVMYVKTY LSFLIEEEEI RTGLQEAYWV 300
  301 GRFEKLQSNP DIIIDGAHNP EGIESLVKTV ESHYKDKNVI VLFTALGDKQ LHNMVGQLET 360
  361 IADEIIFTTF AFDRAISAGE LASYAKKESK LVFENWKEAI DTKVEMIGEN DVFIITGSLY 420
  421 FISEVRKYIR EKN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.0
Match:	1o5zA
Description:	Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at 2.10 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acid-amino acid ligase activity	4.03401034724886	bayes_pls_golite062009
tetrahydrofolylpolyglutamate synthase activity	3.94486215528378	bayes_pls_golite062009
ligase activity	3.80574681739772	bayes_pls_golite062009
catalytic activity	2.66037860982128	bayes_pls_golite062009
dihydrofolate synthase activity	2.50201834836027	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.96801058335544	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: