YRC Public Data Repository - Protein Structure Prediction

Protein:	ILVD_ECOBW
Organism:	Escherichia coli BW2952
Length:	616 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ILVD_ECOBW.

Description	E-value	Query Range	Subject Range
gi\|192926214, gi... - gi\|75255778\|ref\|ZP_00727532.1\| COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Esch... gi\|193071056, gi... - gi\|75234068\|ref\|ZP_00718481.1\| COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Esch... gi\|190903830, gi... - gi\|75230739\|ref\|ZP_00717202.1\| COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Esch... ILVD_ECO8A - Dihydroxy-acid dehydratase OS=Escherichia coli O8 (strain IAI1) GN=ilvD PE=3 SV=1 gi\|75209006, gi\|... - gi\|75209006\|ref\|ZP_00709270.1\| COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Esch... ILVD_ECO24 - Dihydroxy-acid dehydratase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=ilvD PE=3 SV=1 ILVD_SHIF8 - Dihydroxy-acid dehydratase OS=Shigella flexneri serotype 5b (strain 8401) GN=ilvD PE=3 SV=1 ILVD_ECOSE - Dihydroxy-acid dehydratase OS=Escherichia coli (strain SE11) GN=ilvD PE=3 SV=1	942.0	[0..1]	[616..1]
ILVD_ECOK1 - Dihydroxy-acid dehydratase OS=Escherichia coli O1:K1 / APEC GN=ilvD PE=3 SV=1 gi\|237702782, gi... - gi\|237702782\|ref\|ZP_04533263.1\| dihydroxy-acid dehydratase [Escherichia sp. 3_2_53FAA], gi\|226902953... ILVD_ECOUT - Dihydroxy-acid dehydratase OS=Escherichia coli (strain UTI89 / UPEC) GN=ilvD PE=3 SV=1	942.0	[0..1]	[616..1]
ILVD_SHIBS - Dihydroxy-acid dehydratase OS=Shigella boydii serotype 4 (strain Sb227) GN=ilvD PE=3 SV=1 ILVD_SHIB3 - Dihydroxy-acid dehydratase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=ilvD PE=3 ...	942.0	[0..1]	[616..1]
gi\|209753578, gi... - pir\|\|B86063 dihydroxyacid dehydratase [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15804362, gi\|... - gi\|15804362\|ref\|NP_290402.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 EDL933], gi\|125186... ILVD_ECO57 - Dihydroxy-acid dehydratase OS=Escherichia coli O157:H7 GN=ilvD PE=3 SV=3 gi\|15833959, gi\|... - gi\|15833959\|ref\|NP_312732.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. Sakai], gi\|13... gi\|208740271, gi... - gi\|208820148\|ref\|ZP_03260468.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4042], g... gi\|208735016, gi... - gi\|208813739\|ref\|ZP_03255068.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4045], g... gi\|217326565, gi... - gi\|217326565\|ref\|ZP_03442649.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. TW14588], ... ILVD_ECO5E - Dihydroxy-acid dehydratase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=ilvD PE=3 SV=1 gi\|189376788, gi... - gi\|189376788\|gb\|EDU95204.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC508], gi\|168... gi\|189373255, gi... - gi\|189373255\|gb\|EDU91671.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC869], gi\|168... gi\|208726056, gi... - gi\|208806255\|ref\|ZP_03248592.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4206], g... gi\|195938060 - gi\|195938060\|ref\|ZP_03083442.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4024] gi\|189362687, gi... - gi\|189362687\|gb\|EDU81106.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4486], gi\|16... gi\|189365809, gi... - gi\|189365809\|gb\|EDU84225.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4501], gi\|16... gi\|168780667, gi... - gi\|189001570\|gb\|EDU70556.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4076], gi\|16... gi\|187768890, gi... - gi\|187768890\|gb\|EDU32734.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4196], gi\|16... gi\|189359330, gi... - gi\|189359330\|gb\|EDU77749.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4401], gi\|16... gi\|188014282, gi... - gi\|188014282\|gb\|EDU52404.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4113], gi\|16... gi\|254795770, gi... - gi\|254795770\|ref\|YP_003080607.1\| dihydroxyacid dehydratase [Escherichia coli O157:H7 str. TW14359], ...	941.0	[0..1]	[616..1]
gi\|191174378, gi... - gi\|75236527\|ref\|ZP_00720617.1\| COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Esch... ILVD_ECO81 - Dihydroxy-acid dehydratase OS=Escherichia coli O81 (strain ED1a) GN=ilvD PE=3 SV=1 ILVD_ECOL5 - Dihydroxy-acid dehydratase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=ilvD PE=3 SV=1	941.0	[0..1]	[616..1]
ILVD_SHISS - Dihydroxy-acid dehydratase OS=Shigella sonnei (strain Ss046) GN=ilvD PE=3 SV=1	941.0	[0..1]	[616..1]
gi\|194434625, gi... - gi\|83569047\|ref\|ZP_00920509.1\| COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Shig...	940.0	[0..1]	[616..1]
gi\|124498673, gi... - gi\|124531296\|ref\|ZP_01701632.1\| dihydroxy-acid dehydratase [Escherichia coli B], gi\|124498673\|gb\|EAY... ILVD_ECOHS - Dihydroxy-acid dehydratase OS=Escherichia coli O9:H4 (strain HS) GN=ilvD PE=3 SV=1 gi\|194438644, gi... - gi\|83585974\|ref\|ZP_00924613.1\| COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Esch... gi\|251787031, gi... - gi\|251787031\|ref\|YP_003001335.1\| hypothetical protein B21_03598 [Escherichia coli BL21], gi\|24237930... ILVD_ECOLC - Dihydroxy-acid dehydratase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=ilvD PE=3 S... gi\|253975617, gi... - gi\|254163716\|ref\|YP_003046824.1\| dihydroxy-acid dehydratase [Escherichia coli B str. REL606], gi\|253... gi\|253326646, gi... - gi\|254290466\|ref\|YP_003056214.1\| dihydroxy-acid dehydratase [Escherichia coli BL21(DE3)], gi\|2539797...	940.0	[0..1]	[616..1]
ILVD_SALPK - Dihydroxy-acid dehydratase OS=Salmonella paratyphi A (strain AKU_12601) GN=ilvD PE=3 SV=1 ILVD_SALPA - Dihydroxy-acid dehydratase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=ilvD PE=3 SV=1 ILVD_SALPA - Dihydroxy-acid dehydratase OS=Salmonella paratyphi A GN=ilvD PE=3 SV=1	940.0	[0..1]	[616..1]
ILVD_VIBPA - Dihydroxy-acid dehydratase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=ilvD P... ILVD_VIBPA - Dihydroxy-acid dehydratase OS=Vibrio parahaemolyticus GN=ilvD PE=3 SV=1	940.0	[0..1]	[616..1]

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Predicted Domain #1

Region A:
Residues: [1-616]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKYRSATTT HGRNMAGARA LWRATGMTDA DFGKPIIAVV NSFTQFVPGH VHLRDLGKLV  60
   61 AEQIEAAGGV AKEFNTIAVD DGIAMGHGGM LYSLPSRELI ADSVEYMVNA HCADAMVCIS 120
  121 NCDKITPGML MASLRLNIPV IFVSGGPMEA GKTKLSDQII KLDLVDAMIQ GADPKVSDSQ 180
  181 SDQVERSACP TCGSCSGMFT ANSMNCLTEA LGLSQPGNGS LLATHADRKQ LFLNAGKRIV 240
  241 ELTKRYYEQN DESALPRNIA SKAAFENAMT LDIAMGGSTN TVLHLLAAAQ EAEIDFTMSD 300
  301 IDKLSRKVPQ LCKVAPSTQK YHMEDVHRAG GVIGILGELD RAGLLNRDVK NVLGLTLPQT 360
  361 LEQYDVMLTQ DDAVKNMFRA GPAGIRTTQA FSQDCRWDTL DDDRANGCIR SLEHAYSKDG 420
  421 GLAVLYGNFA ENGCIVKTAG VDDSILKFTG PAKVYESQDD AVEAILGGKV VAGDVVVIRY 480
  481 EGPKGGPGMQ EMLYPTSFLK SMGLGKACAL ITDGRFSGGT SGLSIGHVSP EAASGGSIGL 540
  541 IEDGDLIAID IPNRGIQLQV SDAELAARRE AQDARGDKAW TPKNRERQVS FALRAYASLA 600
  601 TSADKGAVRD KSKLGG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	171.0
Match:	2gp4A
Description:	No description for 2gp4A was found.

Predicted functions:

Term	Confidence	Notes
3-isopropylmalate dehydratase activity	5.35660492472618	bayes_pls_golite062009
dihydroxy-acid dehydratase activity	1.86041876362237	bayes_pls_golite062009
catalytic activity	1.61959327305722	bayes_pls_golite062009
carbon-oxygen lyase activity	1.16841092671386	bayes_pls_golite062009
hydro-lyase activity	1.13002130445077	bayes_pls_golite062009
lyase activity	1.11228159918123	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: