YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|207346343
Organism:	Saccharomyces cerevisiae AWRI1631
Length:	221 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|207346343.

Description	E-value	Query Range	Subject Range
gi\|151942373 - gi\|151942373\|gb\|EDN60729.1\| HGPRTase [Saccharomyces cerevisiae YJM789] gi\|207346343 - gi\|207346343\|gb\|EDZ72866.1\| YDR399Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190404664 - gi\|190404664\|gb\|EDV07931.1\| hypoxanthine guanine phosphoribosyltransferase [Saccharomyces cerevisiae... HPRT_YEAST - Hypoxanthine-guanine phosphoribosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28... HPT1 - Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine mono...	1.0E-40	[1..221]	[1..221]
HPRT_CHICK - Hypoxanthine-guanine phosphoribosyltransferase OS=Gallus gallus GN=HPRT1 PE=2 SV=1	2.0E-32	[3..180]	[31..207]
TILS_LISIN - Bifunctional protein TilS/HprT OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=tilS/hprT PE=3 ... TILS_LISIN - Bifunctional protein tilS/hprT OS=Listeria innocua GN=tilS/hprT PE=3 SV=1	5.0E-32	[3..182]	[473..642]
gi\|309315, gi\|73... - gi\|7305155\|ref\|NP_038584.1\| hypoxanthine guanine phosphoribosyl transferase 1 [Mus musculus], gi\|309...	7.0E-32	[2..180]	[30..207]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-31	[2..180]	[30..207]
HPRT_RAT - Hypoxanthine-guanine phosphoribosyltransferase OS=Rattus norvegicus GN=Hprt1 PE=1 SV=1 gi\|244376, gi\|21... - gi\|244376\|gb\|AAB21288.1\| hypoxanthine phosphoribosyltransferase; HPRT [Rattus sp.], gi\|2117729\|pir\|\|...	1.0E-31	[2..180]	[30..207]
HPRT1 - hypoxanthine phosphoribosyltransferase 1 gi\|157928964, gi... - gi\|61358070\|gb\|AAX41497.1\| hypoxanthine phosphoribosyltransferase 1 [synthetic construct], gi\|613580... HPRT_MACFA - Hypoxanthine-guanine phosphoribosyltransferase OS=Macaca fascicularis GN=HPRT1 PE=2 SV=3	2.0E-31	[2..180]	[30..207]
gi\|153997549, gi... - gi\|153997549\|ref\|ZP_02022649.1\| hypoxanthine phosphoribosyltransferase [Yersinia pestis CA88-4125], ... gi\|25286886 - pir\|\|AB0414 hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) [imported] - Yersinia pestis (strain... gi\|229695413, gi... - gi\|229839047\|ref\|ZP_04459206.1\| hypoxanthine phosphoribosyltransferase [Yersinia pestis biovar Orien... gi\|229687104, gi... - gi\|229899612\|ref\|ZP_04514753.1\| hypoxanthine phosphoribosyltransferase [Yersinia pestis biovar Orien... gi\|115349036, gi... - gi\|218930425\|ref\|YP_002348300.1\| hypoxanthine phosphoribosyltransferase [Yersinia pestis CO92], gi\|1...	2.0E-31	[1..183]	[1..175]

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Predicted Domain #1

Region A:
Residues: [1-221]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANDKQYIS YNNVHQLCQV SAERIKNFKP DLIIAIGGGG FIPARILRTF LKEPGVPTIR  60
   61 IFAIILSLYE DLNSVGSEVE EVGVKVSRTQ WIDYEQCKLD LVGKNVLIVD EVDDTRTTLH 120
  121 YALSELEKDA AEQAKAKGID TEKSPEMKTN FGIFVLHDKQ KPKKADLPAE MLNDKNRYFA 180
  181 AKTVPDKWYA YPWESTDIVF HTRMAIEQGN DIFIPEQEHK Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.221849
Match:	1bzyA_
Description:	Hypoxantine-guanine PRTase (HGPRTase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity, transferring glycosyl groups	3.91023158228049	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	3.89356447922614	bayes_pls_golite062009
adenine phosphoribosyltransferase activity	3.83339863213875	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
uracil phosphoribosyltransferase activity	2.36237864658341	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
transferase activity	2.03376808731027	bayes_pls_golite062009
amidophosphoribosyltransferase activity	1.51802880667162	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	1.18255665419929	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
purine binding	0.745430157183377	bayes_pls_golite062009
nucleic acid binding	0.552133387792911	bayes_pls_golite062009
binding	0.535390228935555	bayes_pls_golite062009
DNA binding	0.439741935655503	bayes_pls_golite062009
transcription regulator activity	0.396538943915776	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.148898393751978	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: