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View Structure Prediction Details

Protein: gi|220951056, gi...
Organism: synthetic construct
Length: 276 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|220951056, gi....

Description E-value Query
Range		 Subject
Range
gi|83755009, gi|... - gi|83755010|pdb|2EX4|B Chain B, Crystal Structure Of Human Methyltransferase Ad-003 In Complex With ...
 150.0 [0..51] [271..19]
NTM1A_MOUSE - N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Mus musculus GN=Ntmt1 PE=1 SV=3
 149.0 [0..51] [271..1]
gi|125807802, gi... - gi|54635696|gb|EAL25099.1| GA14125-PA [Drosophila pseudoobscura], gi|125807802|ref|XP_001360524.1| G...
 149.0 [0..57] [272..1]
NTM1A_RAT - N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Rattus norvegicus GN=Ntmt1 PE=2 SV=3
 149.0 [0..51] [271..1]
gi|114627144, gi... - gi|55632451|ref|XP_520309.1| PREDICTED: similar to Chromosome 9 open reading frame 32 isoform 5 [Pan...
 147.0 [0..51] [271..1]
NTM1_CAEBR - Alpha N-terminal protein methyltransferase 1 OS=Caenorhabditis briggsae GN=homt-1 PE=3 SV=1
gi|157745933 - gi|157745933|ref|XP_001668063.1| Hypothetical protein CBG03917 [Caenorhabditis briggsae AF16]
 144.0 [0..51] [276..1]
NTM1A_BOVIN - N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Bos taurus GN=NTMT1 PE=2 SV=3
 143.0 [0..51] [271..1]
NT1AA_XENLA - N-terminal Xaa-Pro-Lys N-methyltransferase 1-A OS=Xenopus laevis GN=ntmt1-a PE=2 SV=1
 143.0 [0..51] [271..1]
NTM1_ARATH - Alpha N-terminal protein methyltransferase 1 OS=Arabidopsis thaliana GN=At5g44450 PE=2 SV=1
 142.0 [0..56] [270..29]

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Predicted Domain #1
Region A:
Residues: [1-276] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTLEEQLS DKLQMMDETT DKVQGSSKQK DDSSIAASSD AKTASPSSSD SSTKVAAPES  60
   61 EFYNKAQKYW SEVPATVNGM LGGLGYISAI DIQGSNVFLR EIRVPGNRLA LDCGAGIGRV 120
  121 TRNLLIPRFS CVDLVEQDPA FADKAREYCT SEDGSRGKVG QIYNVGLQKF TPTQQYDLVW 180
  181 TQWVLGHLTD RDLVSFFRRI KQGLAPGAFL CLKENVSSSK KTVEDRNDSS VTRPLDSYEH 240
  241 FLKEAGFRIV RKVKQQNFPK GLFPVYMIAC KPVSKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.39794
Match: 2ex4A
Description: Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methyltransferase activity 3.57681394097837 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 3.49392219433935 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
rRNA methyltransferase activity 2.5924681776558 bayes_pls_golite062009
tRNA methyltransferase activity 1.76571145896453 bayes_pls_golite062009
N-methyltransferase activity 1.57269280784007 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
protein methyltransferase activity 0.94499223839747 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.794703281700029 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.716476158062361 bayes_pls_golite062009
DNA binding 0.71058003448013 bayes_pls_golite062009
nucleic acid binding 0.698509190696763 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
rRNA (guanine) methyltransferase activity 0.0854264678700428 bayes_pls_golite062009
histone methyltransferase activity 0.0408000230099101 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle