YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|221230003, gi...
Organism:	Mycobacterium leprae Br4923
Length:	263 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|221230003, gi....

Description	E-value	Query Range	Subject Range
gi\|2062634 - gi\|2062634\|gb\|AAC45219.1\| extracytoplasmic function alternative sigma factor [Mycobacterium avium] gi\|41408655, gi\|... - gi\|41408655\|ref\|NP_961491.1\| RNA polymerase sigma factor SigE [Mycobacterium avium subsp. paratuberc...	169.0	[0..7]	[259..1]
gi\|224989625, gi... - gi\|224989625\|ref\|YP_002644312.1\| RNA polymerase sigma factor [Mycobacterium bovis BCG str. Tokyo 172... gi\|219557111 - gi\|219557111\|ref\|ZP_03536187.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis T17] gi\|215445395 - gi\|215445395\|ref\|ZP_03432147.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis T85] gi\|215430099 - gi\|215430099\|ref\|ZP_03428018.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis EAS054] SIGE_MYCTU - ECF RNA polymerase sigma factor SigE OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=si... gi\|31792414, gi\|... - gi\|31792414\|ref\|NP_854907.1\| RNA polymerase sigma factor SigE [Mycobacterium bovis AF2122/97], gi\|31... gi\|121637150, gi... - gi\|121637150\|ref\|YP_977373.1\| RNA polymerase sigma factor SigE [Mycobacterium bovis BCG str. Pasteur... gi\|254550226 - gi\|254550226\|ref\|ZP_05140673.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis '98-R60... SIGE_MYCTO - ECF RNA polymerase sigma factor SigE OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) GN=si... gi\|253799735, gi... - gi\|253799735\|ref\|YP_003032736.1\| alternative RNA polymerase sigma factor sigE [Mycobacterium tubercu... gi\|124600542, gi... - gi\|254231483\|ref\|ZP_04924810.1\| alternative RNA polymerase sigma factor sigE [Mycobacterium tubercul... gi\|255096000 - gi\|255096000\|ref\|ZP_05325478.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis KZN 605... gi\|148720963, gi... - gi\|148822436\|ref\|YP_001287190.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis F11], ... gi\|254815022 - gi\|254815022\|ref\|ZP_05220023.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis KZN 420... SIGE_MYCTE - ECF RNA polymerase sigma factor SigE OS=Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Er... gi\|215426528 - gi\|215426528\|ref\|ZP_03424447.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis T92] gi\|215410852 - gi\|215410852\|ref\|ZP_03419660.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis 94_M424... gi\|215403058 - gi\|215403058\|ref\|ZP_03415239.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis 02_1987... gi\|254364121, gi... - gi\|254364121\|ref\|ZP_04980167.1\| alternative RNA polymerase sigma factor sigE [Mycobacterium tubercul... gi\|148661008, gi... - gi\|167967897\|ref\|ZP_02550174.1\| RNA polymerase sigma factor SigE [Mycobacterium tuberculosis H37Ra],... SIGE_MYCTU - ECF RNA polymerase sigma factor SigE OS=Mycobacterium tuberculosis GN=sigE PE=1 SV=1	160.0	[0..10]	[261..5]
gi\|162605994, gi... - pir\|\|D90084 RNA-polymerase sigma factor [imported] - Guillardia theta nucleomorph, gi\|162605994\|ref...	148.0	[0..8]	[263..185]
gi\|196253313, gi... - gi\|196253313\|ref\|ZP_03151946.1\| RNA polymerase, sigma-24 subunit, ECF subfamily [Clostridium thermoc... gi\|67849833, gi\|... - gi\|67916230\|ref\|ZP_00509948.1\| Sigma-70 region 2:Sigma-70 region 4 [Clostridium thermocellum ATCC 27...	147.0	[0..73]	[249..5]
gi\|118432700, gi... - gi\|118586868\|ref\|ZP_01544302.1\| DNA-directed RNA polymerase RpoD, sigma subunit, Sigma-42 [Oenococcu... gi\|71466858 - gi\|71466858\|emb\|CAH41003.1\| rpoD protein [Oenococcus oeni]	144.0	[0..2]	[250..213]
gi\|47679387 - gi\|47679387\|gb\|AAT36674.1\| DNA-directed RNA polymerase sigma A subunit [Oenococcus oeni PSU-1]	144.0	[0..2]	[250..220]
gi\|158140438, gi... - gi\|158320239\|ref\|YP_001512746.1\| ECF subfamily RNA polymerase sigma-24 factor [Alkaliphilus oremland...	144.0	[0..73]	[246..5]
gi\|82501232, gi\|... - gi\|82501232\|ref\|ZP_00886592.1\| Sigma-70 factor [Caldicellulosiruptor saccharolyticus DSM 8903], gi\|8...	142.0	[0..8]	[241..171]

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Predicted Domain #1

Region A:
Residues: [1-79]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDGIGMERE GRWTGNTQCP LRVVPGDESP TLDGRASPED LIITNLLSPT IMSHPPPSRD  60
   61 DDWVEPFDAL QGTAVFDAT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.30103
Match:	1ku2A
Description:	Sigma factor SigA
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [80-263]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDKATMPSWE ELVRQHAARV YWLAYRLSGN QHDAEDLTQE TFIRVFRSVQ NYQPGTFEGW  60
   61 LHRITTNLFL DMVRRRARIR MDALPDDYDR VPADEPNPEQ IYHDSRLGPD LQAALDSLPP 120
  121 EFRAAVVLCD IEGLSYEEIG ATLGVKLGTV RSRIHRGRQA LRDYLLTAHP RDGATTDATH 180
  181 VKSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.39794
Match:	1or7A
Description:	SigmaE factor (RpoE)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription initiation factor activity	5.71806750193815	bayes_pls_golite062009
sigma factor activity	5.58029806879061	bayes_pls_golite062009
transcription regulator activity	3.67872017549582	bayes_pls_golite062009
binding	1.02634976114785	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: