YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|213853089
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. M223
Length:	322 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|213853089.

Description	E-value	Query Range	Subject Range
gi\|77633668, gi\|... - gi\|77633668\|ref\|ZP_00795789.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|149292704, gi... - gi\|149366291\|ref\|ZP_01888326.1\| PTS system, mannose-specific IIAB component [Yersinia pestis CA88-41... gi\|165938794, gi... - gi\|89104609\|ref\|ZP_01177148.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|145210348, gi... - gi\|145598652\|ref\|YP_001162728.1\| PTS system, mannose-specific IIAB component [Yersinia pestis Pestoi... gi\|108807126, gi... - gi\|108807126\|ref\|YP_651042.1\| PTS system, mannose-specific IIAB component [Yersinia pestis Antiqua],... gi\|229902909, gi... - gi\|229902909\|ref\|ZP_04518026.1\| mannose-specific PTS enzyme [Yersinia pestis Nepal516], gi\|229680356... gi\|25287843 - pir\|\|AE0214 protein-Npi-phosphohistidine-sugar phosphotransferase (EC 2.7.1.69) IIAB component [impo... gi\|51595970, gi\|... - gi\|51595970\|ref\|YP_070161.1\| PTS system, mannose-specific IIAB component [Yersinia pseudotuberculosi... gi\|22126432, gi\|... - gi\|22126432\|ref\|NP_669855.1\| PTS system, mannose-specific IIAB component [Yersinia pestis KIM], gi\|2... gi\|166210521, gi... - gi\|166210521\|ref\|ZP_02236556.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|15979785, gi\|... - gi\|218928882\|ref\|YP_002346757.1\| PTS system, mannose-specific IIAB component [Yersinia pestis CO92],... gi\|166010853, gi... - gi\|166010853\|ref\|ZP_02231751.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|166961879, gi... - gi\|167420184\|ref\|ZP_02311937.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|167402186, gi... - gi\|167402186\|ref\|ZP_02307661.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|170024689, gi... - gi\|170024689\|ref\|YP_001721194.1\| PTS system mannose/fructose/sorbose family IIB subunit [Yersinia ps... gi\|167425847, gi... - gi\|167425847\|ref\|ZP_02317600.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia... gi\|186895069, gi... - gi\|186895069\|ref\|YP_001872181.1\| PTS system mannose/fructose/sorbose family IIB subunit [Yersinia ps... gi\|229896196, gi... - gi\|229896196\|ref\|ZP_04511366.1\| mannose-specific PTS enzyme [Yersinia pestis Pestoides A], gi\|229701... gi\|229693469, gi... - gi\|229897132\|ref\|ZP_04512288.1\| mannose-specific PTS enzyme [Yersinia pestis biovar Orientalis str. ... Q66BY2\|Q66BY2_YERPS - PTS system, mannose-specific IIAB component - Yersinia pseudotuberculosis gi\|229897859, gi... - gi\|229897859\|ref\|ZP_04513010.1\| mannose-specific PTS enzyme [Yersinia pestis biovar Orientalis str. ... gi\|165920046, gi... - gi\|165927989\|ref\|ZP_02223821.1\| PTS system, mannose/fructose/sorbose family, IIB component [Yersinia...	0.0	[1..322]	[1..324]
gi\|153950698, gi... - gi\|77628834\|ref\|ZP_00791420.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos...	0.0	[1..322]	[1..324]
gi\|5669855 - gi\|5669855\|gb\|AAD46485.1\|AF130465_1 mannose-specific phosphotransferase system component IIAB [Strep... gi\|228476592, gi... - gi\|228476592\|ref\|ZP_04061274.1\| mannose-specific phosphotransferase system component iiab [Streptoco...	0.0	[1..321]	[1..328]
gi\|197261643, gi... - gi\|197261643\|ref\|ZP_03161717.1\| PTS system, mannose-specific IIAB component [Salmonella enterica sub... lcl\|NC_016856.1_... - [gene=manX] [protein=mannose-specific enzyme IIAB] [protein_id=YP_005237771.1] [location=1939938..19... gi\|197093654, gi... - gi\|197362177\|ref\|YP_002141814.1\| PTS system, mannose-specific IIAB component [Salmonella enterica su... gi\|194405321, gi... - gi\|194446658\|ref\|YP_002041086.1\| PTS system, mannose-specific IIAB component [Salmonella enterica su... gi\|194448000, gi... - gi\|194448000\|ref\|YP_002045876.1\| PTS system, mannose-specific IIAB component [Salmonella enterica su... gi\|16420362, gi\|... - gi\|16765171\|ref\|NP_460786.1\| mannose-specific enzyme IIAB [Salmonella typhimurium LT2], gi\|16420362\|... gi\|168241424, gi... - gi\|205339563\|gb\|EDZ26327.1\| PTS system, mannose-specific IIAB component [Salmonella enterica subsp. ... gi\|205350893, gi... - gi\|205350893\|gb\|EDZ37524.1\| PTS system, mannose-specific IIAB component [Salmonella enterica subsp. ... gi\|167553488, gi... - gi\|205322074\|gb\|EDZ09913.1\| PTS system, mannose-specific IIAB component [Salmonella enterica subsp. ... gi\|224583679, gi... - gi\|224583679\|ref\|YP_002637477.1\| PTS system, mannose-specific IIAB component [Salmonella enterica su... gi\|56413251, gi\|... - gi\|56413251\|ref\|YP_150326.1\| PTS system, mannose-specific IIAB component [Salmonella enterica subsp....	0.0	[1..322]	[1..322]
gi\|75241314, gi\|... - gi\|75241314\|ref\|ZP_00725165.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|110641934, gi... - gi\|110641934\|ref\|YP_669664.1\| PTS system, mannose-specific IIAB component [Escherichia coli 536], gi...	0.0	[1..322]	[1..323]
gi\|77959077, gi\|... - gi\|77959077\|ref\|ZP_00823100.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos...	0.0	[1..322]	[1..321]
gi\|62180394, gi\|... - gi\|62180394\|ref\|YP_216811.1\| sugar specific PTS family mannose-specific enzyme IIAB [Salmonella ente...	0.0	[1..322]	[1..322]
gi\|77972312, gi\|... - gi\|77972312\|ref\|ZP_00827882.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos...	0.0	[1..322]	[1..324]
gi\|90961631, gi\|... - gi\|90961631\|ref\|YP_535547.1\| PTS system, mannose-specific IIAB component [Lactobacillus salivarius U...	0.0	[2..321]	[1..323]
gi\|110614938, gi... - gi\|110805390\|ref\|YP_688910.1\| PTS enzyme IIAB [Shigella flexneri 5 str. 8401], gi\|110614938\|gb\|ABF03... EG10567 - fused mannose-specific PTS enzymes: IIA component /IIB component / Mannose permease, EIIAB component;... gi\|30041178, gi\|... - gi\|30062929\|ref\|NP_837100.1\| PTS enzyme IIAB [Shigella flexneri 2a str. 2457T], gi\|30041178\|gb\|AAP16... gi\|74311870, gi\|... - gi\|74311870\|ref\|YP_310289.1\| PTS enzyme IIAB, mannose-specific [Shigella sonnei Ss046], gi\|73855347\|... PTNAB_ECO57 - PTS system mannose-specific EIIAB component OS=Escherichia coli O157:H7 GN=manX PE=3 SV=2 PTNAB_ECOL6 - PTS system mannose-specific EIIAB component OS=Escherichia coli O6 GN=manX PE=3 SV=2 EG10567 - fused mannose-specific PTS enzymes: IIA component /IIB component / Mannose permease, EIIAB component;... gi\|75255556, gi\|... - gi\|75255556\|ref\|ZP_00727343.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|188492671, gi... - gi\|75513686\|ref\|ZP_00736062.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|168749349, gi... - gi\|188016260\|gb\|EDU54382.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 st... gi\|82543739, gi\|... - gi\|82543739\|ref\|YP_407686.1\| PTS enzyme IIAB, mannose-specific [Shigella boydii Sb227], gi\|81245150\|... gi\|168758132, gi... - gi\|189355011\|gb\|EDU73430.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 st... gi\|189365715, gi... - gi\|189365715\|gb\|EDU84131.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 st... gi\|254592840, gi... - gi\|254793440\|ref\|YP_003078277.1\| mannose-specific PTS enzyme [Escherichia coli O157:H7 str. TW14359]... gi\|187731326, gi... - gi\|75177250\|ref\|ZP_00697339.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|254161876, gi... - gi\|254161876\|ref\|YP_003044984.1\| fused mannose-specific PTS enzymes: IIA component/IIB component [Es... gi\|157080889, gi... - gi\|75190848\|ref\|ZP_00704115.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|253773229, gi... - gi\|254288664\|ref\|YP_003054412.1\| fused mannose-specific PTS enzymes: IIA component/IIB component [Es... gi\|242377537, gi... - gi\|251785264\|ref\|YP_002999568.1\| hypothetical protein B21_01775 [Escherichia coli BL21], gi\|24237753... gi\|194439634, gi... - gi\|83585002\|ref\|ZP_00923657.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|238861210, gi... - gi\|238901031\|ref\|YP_002926827.1\| fused mannose-specific PTS enzymes: IIA component/IIB component [Es... gi\|75215178, gi\|... - gi\|75215178\|ref\|ZP_00713623.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|227837330, gi... - gi\|227885757\|ref\|ZP_04003562.1\| protein-N(pi)-phosphohistidine--sugar phosphotransferase [Escherichi... gi\|190901121, gi... - gi\|75227921\|ref\|ZP_00714621.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|75195884, gi\|... - gi\|75195884\|ref\|ZP_00705954.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|194430019, gi... - gi\|75208750\|ref\|ZP_00709042.1\| COG3444: Phosphotransferase system, mannose/fructose/N-acetylgalactos... gi\|208731111, gi... - gi\|208816768\|ref\|ZP_03257888.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H... gi\|208741139, gi... - gi\|208821016\|ref\|ZP_03261336.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H... gi\|209160968, gi... - gi\|209399568\|ref\|YP_002270896.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:... gi\|209912441, gi... - gi\|209919182\|ref\|YP_002293266.1\| PTS system mannose-specific IIAB components [Escherichia coli SE11]... gi\|217317966, gi... - gi\|217328619\|ref\|ZP_03444700.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H... gi\|218361157, gi... - gi\|218554389\|ref\|YP_002387302.1\| fused mannose-specific PTS enzymes: IIA component ; IIB component [... gi\|218352111, gi... - gi\|218695379\|ref\|YP_002403046.1\| fused mannose-specific PTS enzymes: IIA component ; IIB component [... gi\|218432412, gi... - gi\|218705315\|ref\|YP_002412834.1\| fused mannose-specific PTS enzymes: IIA component ; IIB component [... gi\|168770795, gi... - gi\|189360337\|gb\|EDU78756.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 st... gi\|168774864, gi... - gi\|187769489\|gb\|EDU33333.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 st... gi\|1736455, gi\|8... - gi\|89108656\|ref\|AP_002436.1\| fused mannose-specific PTS enzyme IIAB components [Escherichia coli str... gi\|189000300, gi... - gi\|189000300\|gb\|EDU69286.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 st... gi\|13361994, gi\|... - gi\|15831781\|ref\|NP_310554.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 s... gi\|189371916, gi... - gi\|189371916\|gb\|EDU90332.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H7 st... PTNAB_SHIFL - PTS system mannose-specific EIIAB component OS=Shigella flexneri GN=manX PE=3 SV=2 gi\|170081472, gi... - gi\|170081472\|ref\|YP_001730792.1\| fused mannose-specific PTS enzymes: IIA component; IIB component [E... PTNAB_ECOLI - PTS system mannose-specific EIIAB component (EIIAB-Man) [Includes: Mannose-specific phosphotransfera... gi\|170517999, gi... - gi\|170680281\|ref\|YP_001743429.1\| PTS system, mannose-specific IIAB component [Escherichia coli SMS-3... gi\|24112795, gi\|... - gi\|24112795\|ref\|NP_707305.1\| PTS enzyme IIAB [Shigella flexneri 2a str. 301], gi\|24051725\|gb\|AAN4301... gi\|195940311 - gi\|195940311\|ref\|ZP_03085693.1\| fused mannose-specific PTS enzymes: IIA component; IIB component [Es... PTNAB_ECOL6 - PTS system mannose-specific EIIAB component OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 /... gi\|208725186, gi... - gi\|208810670\|ref\|ZP_03252546.1\| PTS system, mannose-specific IIAB component [Escherichia coli O157:H...	0.0	[1..322]	[1..323]

Back

Predicted Domain #1

Region A:
Residues: [1-147]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIAIVIGTH GWAAEQLLKT AEMLLGEQEN VGWIDFVPGE NAETLIEKYN AQLAKLDTSK  60
   61 GVLFLVDTWG GSPFNAASRI VVDKERYEVI AGVNIPMLVE TFMARDDDPS FDELVALAVE 120
  121 TGREGVKALK AKPVEKAAPA PVAAAPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.39794
Match:	1vrcA
Description:	Complex of enzyme IIAmannose and the histidine-containing phosphocarrier protein HPr from escherichia coli nmr, restrained regularized mean structure
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate transmembrane transporter activity	1.41958257592479	bayes_pls_golite062009
binding	1.3313872030407	bayes_pls_golite062009
protein binding	0.504276536503861	bayes_pls_golite062009
transporter activity	0.433212475678148	bayes_pls_golite062009
transmembrane transporter activity	0.21078048070603	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [148-322]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AATPAKPMGP NDYMVIGLAR IDDRLIHGQV ATRWTKETNV SRIIVVSDEV AADTVRKTLL  60
   61 TQVAPPGVTA HVVDVAKMIR VYNNPKYAGE RVMLLFTNPT DVERIVEGGV KVTSVNIGGM 120
  121 AYRQGKTQVN NAVSVDEKDI EAFKKLNERG IELEVRKVST DPKLKMMDLI AKVAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.0
Match:	1nrzA
Description:	Sorbose permease subunit IIb , EIIb-sor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate transmembrane transporter activity	3.89825676747483	bayes_pls_golite062009
transporter activity	2.00960396164678	bayes_pls_golite062009
transmembrane transporter activity	1.86135605657276	bayes_pls_golite062009
substrate-specific transporter activity	1.70618312780208	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.5973591090727	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.15285098263315	bayes_pls_golite062009
active transmembrane transporter activity	0.669347420921443	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.643818947881128	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: