YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|207346104
Organism:	Saccharomyces cerevisiae AWRI1631
Length:	470 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|207346104.

Description	E-value	Query Range	Subject Range
gi\|190405519 - gi\|190405519\|gb\|EDV08786.1\| fumarate reductase [Saccharomyces cerevisiae RM11-1a] gi\|207346104 - gi\|207346104\|gb\|EDZ72703.1\| YEL047Cp-like protein [Saccharomyces cerevisiae AWRI1631] FRDS_YEAST - Fumarate reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRD1 PE=1 SV=1 YEL047C - Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ri...	0.0	[1..470]	[1..470]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..470]	[1..470]
SDHA_SCHPO - Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Schizosaccharom... sdh1 - succinate dehydrogenase Sdh1	0.0	[4..465]	[55..465]
gi\|15030102 - gi\|15030102\|gb\|AAH11301.1\| Sdha protein [Mus musculus]	2.0E-98	[3..470]	[58..473]
gi\|83592540, gi\|... - gi\|83592540\|ref\|YP_426292.1\| succinate dehydrogenase flavoprotein subunit [Rhodospirillum rubrum ATC... gi\|25284605, gi\|... - ref\|ZP_00269538.1\| COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Rhodos...	4.0E-98	[3..470]	[10..425]
SDHA_RAT - Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Rattus norvegicus GN=Sdh...	5.0E-98	[3..470]	[53..468]
gi\|17429012 - gi\|17429012\|emb\|CAD15696.1\| putative succinate dehydrogenase (flavoprotein subunit) oxidoreductase [... gi\|17546713 - gi\|17546713\|ref\|NP_520115.1\| succinate dehydrogenase flavoprotein subunit [Ralstonia solanacearum GM...	3.0E-97	[3..466]	[12..424]

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Predicted Domain #1

Region A:
Residues: [1-248]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSPVVVIG TGLAGLAAAN ELVNKYNIPV TILEKASSIG GNSIKASSGI NGACTETQRH  60
   61 FHIEDSPRLF EDDTIKSAKG KGVQELMAKL ANDSPLAIEW LKNEFDLKLD LLAQLGGHSV 120
  121 ARTHRSSGKL PPGFEIVSAL SNNLKKLAET KPELVKINLD SKVVDIHEKD GSISAVVYED 180
  181 KNGEKHMVSA NDVVFCSGGF GFSKEMLKEY APELVNLPTT NGQQTTGDGQ RLLQKLGADL 240
  241 IDMDQIQV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [403-470]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHFTMGGARI NVKAQVIGKN DERLLKGLYA AGEVSGGVHG ANRLGGSSLL ECVVFGRTAA  60
   61 ESIANDRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	635.045757
Match:	1qo8A_
Description:	Flavocytochrome c3 (respiratory fumarate reductase), N-terminal domain; Flavocytochrome c3 (respiratory fumarate reductase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
succinate dehydrogenase activity	4.66525249592263	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	3.70791057697947	bayes_pls_golite062009
succinate dehydrogenase (ubiquinone) activity	3.70791057697947	bayes_pls_golite062009
oxidoreductase activity	3.25470541847124	bayes_pls_golite062009
electron carrier activity	2.8553929424231	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	2.84060092432585	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	2.78793325009909	bayes_pls_golite062009
L-aspartate oxidase activity	2.52327499022066	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	2.26549080531565	bayes_pls_golite062009
aspartate oxidase activity	2.16464783424214	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.11247286526577	bayes_pls_golite062009
catalytic activity	1.75556359035561	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	1.73872135285388	bayes_pls_golite062009
binding	1.41440014472974	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.932244769173724	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	0.798505263716232	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	0.71497408952162	bayes_pls_golite062009
fumarate reductase (NADH) activity	0.65260793370113	bayes_pls_golite062009
succinate-CoA ligase activity	0.468246082354334	bayes_pls_golite062009
coenzyme binding	0.44036421821989	bayes_pls_golite062009
protein binding	0.159209309982354	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [249-402]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPTGFIDPND RSSSWKFLAA ESLRGLGGIL LNPITGRRFV NELTTRDVVT AAIQKVCPQE  60
   61 DNRALLVMGE KMYTDLKNNL DFYMFKKLVQ KLTLSQVVSE YNLPITVAQL CEELQTYSSF 120
  121 TTKADPLGRT VILNEFGSDV TPETVVFIGE VTPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	635.045757
Match:	1qo8A_
Description:	Flavocytochrome c3 (respiratory fumarate reductase), N-terminal domain; Flavocytochrome c3 (respiratory fumarate reductase)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: