YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|221140080
Organism:	Staphylococcus aureus subsp. aureus str. JKD6009
Length:	180 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|221140080.

Description	E-value	Query Range	Subject Range
gi\|251810916, gi... - gi\|251810916\|ref\|ZP_04825389.1\| ADP-ribose diphosphatase [Staphylococcus epidermidis BCM-HMP0060], g... gi\|57866974, gi\|... - gi\|57866974\|ref\|YP_188639.1\| MutT/nudix family protein [Staphylococcus epidermidis RP62A], gi\|576376... gi\|27468101, gi\|... - gi\|27468101\|ref\|NP_764738.1\| ADP-ribose pyrophosphatase [Staphylococcus epidermidis ATCC 12228], gi\|...	174.0	[0..1]	[180..1]
gi\|167040190, gi... - gi\|167040190\|ref\|YP_001663175.1\| NUDIX hydrolase [Thermoanaerobacter sp. X514], gi\|166854430\|gb\|ABY9... gi\|241902783, gi... - gi\|241902783\|ref\|ZP_04787514.1\| NUDIX hydrolase [Thermoanaerobacter brockii subsp. finnii Ako-1], gi... gi\|242258345, gi... - gi\|242258345\|ref\|ZP_04803159.1\| NUDIX hydrolase [Thermoanaerobacter sp. X513], gi\|242230130\|gb\|EES32... gi\|76796749, gi\|... - gi\|76796749\|ref\|ZP_00779103.1\| NUDIX hydrolase [Thermoanaerobacter ethanolicus ATCC 33223], gi\|76587...	163.0	[0..1]	[173..1]
gi\|49241878, gi\|... - gi\|49483749\|ref\|YP_040973.1\| putative ADP-ribose pyrophosphatase [Staphylococcus aureus subsp. aureu... gi\|227557695, gi... - gi\|227557695\|ref\|ZP_03987742.1\| ADP-ribose pyrophosphatase [Staphylococcus aureus subsp. aureus MN8]... gi\|227899991, gi... - gi\|227899991\|ref\|ZP_04017796.1\| ADP-ribose pyrophosphatase [Staphylococcus aureus subsp. aureus TCH6...	163.0	[0..1]	[180..1]
gi\|20807759, gi\|... - gi\|20807759\|ref\|NP_622930.1\| NTP pyrophosphohydrolase including oxidative damage repair enzyme [Ther... gi\|20807759 - gi\|20807759\|ref\|NP_622930.1\| NTP pyrophosphohydrolase including oxidative damage repair enzyme [Ther...	163.0	[0..1]	[173..1]
gi\|25303385 - pir\|\|C89929 conserved hypothetical protein SA1330 [imported] - Staphylococcus aureus (strain N315) gi\|269203126\|ref... - MutT/nudix family protein [Staphylococcus aureus subsp. aureus ED98] gi\|253314867 - gi\|253314867\|ref\|ZP_04838080.1\| hypothetical protein SauraC_01580 [Staphylococcus aureus subsp. aure... gi\|255006285 - gi\|255006285\|ref\|ZP_05144886.2\| hypothetical protein SauraM_07450 [Staphylococcus aureus subsp. aure... gi\|156721953, gi... - gi\|156979818\|ref\|YP_001442077.1\| hypothetical protein SAHV_1487 [Staphylococcus aureus subsp. aureus... gi\|90428641, gi\|... - gi\|90582276\|ref\|ZP_01238040.1\| NUDIX hydrolase [Staphylococcus aureus subsp. aureus JH1], gi\|9042864... gi\|15924489, gi\|... - gi\|15924489\|ref\|NP_372023.1\| ADP-ribose pyrophosphatase [Staphylococcus aureus subsp. aureus Mu50], ... gi\|90585117, gi\|... - gi\|90585117\|ref\|ZP_01240828.1\| NUDIX hydrolase [Staphylococcus aureus subsp. aureus JH9], gi\|9043124... gi\|15927080, gi\|... - gi\|15927080\|ref\|NP_374613.1\| hypothetical protein SA1330 [Staphylococcus aureus subsp. aureus N315],...	162.0	[0..1]	[180..1]
gi\|88944793, gi\|... - gi\|88944793\|ref\|ZP_01148017.1\| NTP pyrophosphohydrolases including oxidative damage repair enzymes [...	162.0	[0..2]	[177..3]
gi\|73662562, gi\|... - gi\|73662562\|ref\|YP_301343.1\| putative ADP-ribose pyrophosphatase [Staphylococcus saprophyticus subsp...	162.0	[0..1]	[180..1]
gi\|15643937, gi\|... - gi\|4981730\|gb\|AAD36256.1\|AE001774_13 conserved hypothetical protein [Thermotoga maritima MSB8], gi\|1... gi\|7445034 - pir\|\|H72286 conserved hypothetical protein - Thermotoga maritima (strain MSB8)	160.0	[0..1]	[173..1]
gi\|70726418, gi\|... - gi\|70726418\|ref\|YP_253332.1\| ADP-ribose pyrophosphatase [Staphylococcus haemolyticus JCSC1435], gi\|6...	160.0	[0..1]	[178..1]
gi\|82498927, gi\|... - gi\|82498927\|ref\|ZP_00884381.1\| ADP-ribose pyrophosphatase, putative [Caldicellulosiruptor saccharoly...	159.0	[0..1]	[178..1]

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Predicted Domain #1

Region A:
Residues: [1-180]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLNEKTIDR TVIYNGKIVD VEIHTVTLPN GETSTRELVY HNGAVAVCAV TPKKEVVLVK  60
   61 QYRKPVEKPL LEIPAGKLED DEDRVEAAKR ELEEETGYIA KELTHVVDMY GSPGFCDEQL 120
  121 SIYFTDNLEE GTVHLDEDEF VEVIKVPIEN VKSMLMNKEI EDAKTIIALQ HLLLNYNHSK 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.69897
Match:	1mk1A
Description:	Structure of the MT-ADPRase in complex with ADPR, a Nudix enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.49075808737475	bayes_pls_golite062009
hydrolase activity	1.0879699007552	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.859040726089354	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.859001295204634	bayes_pls_golite062009
pyrophosphatase activity	0.231401568856773	bayes_pls_golite062009
binding	0.165092558977235	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: