YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|170125863, gi...
Organism:	Bacillus anthracis str. A0389
Length:	515 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|170125863, gi....

Description	E-value	Query Range	Subject Range
gi\|221089178, gi... - gi\|221089178\|ref\|ZP_03558700.1\| GMP synthase, large subunit [Geobacillus sp. Y412MC61], gi\|220706876... GUAA_GEOKA - GMP synthase [glutamine-hydrolyzing] OS=Geobacillus kaustophilus GN=guaA PE=3 SV=1 gi\|229328416, gi... - gi\|229500698\|ref\|ZP_04394346.1\| GMP synthase, large subunit [Geobacillus sp. Y412MC52], gi\|229328416... GUAA_GEOKA - GMP synthase [glutamine-hydrolyzing] OS=Geobacillus kaustophilus (strain HTA426) GN=guaA PE=3 SV=1	0.0	[10..515]	[5..510]
GUAA_BACCR - GMP synthase [glutamine-hydrolyzing] OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBR... gi\|229125762, gi... - gi\|229125762\|ref\|ZP_04254790.1\| GMP synthase, large subunit [Bacillus cereus BDRD-Cer4], gi\|22865770...	0.0	[1..515]	[1..515]
gi\|228937552, gi... - gi\|228937552\|ref\|ZP_04100193.1\| GMP synthase, large subunit [Bacillus thuringiensis serovar berliner... gi\|228860640, gi... - gi\|228898997\|ref\|ZP_04063272.1\| GMP synthase, large subunit [Bacillus thuringiensis IBL 4222], gi\|22... gi\|228977009, gi... - gi\|228977009\|ref\|ZP_04137416.1\| GMP synthase, large subunit [Bacillus thuringiensis Bt407], gi\|22878... gi\|74490054, gi\|... - gi\|75762461\|ref\|ZP_00742326.1\| GMP synthase (glutamine-hydrolyzing) [Bacillus thuringiensis serovar ... gi\|228789288, gi... - gi\|228970439\|ref\|ZP_04131093.1\| GMP synthase, large subunit [Bacillus thuringiensis serovar thuringi...	0.0	[1..515]	[1..515]
GUAA_BACHK - GMP synthase [glutamine-hydrolyzing] OS=Bacillus thuringiensis subsp. konkukian (strain 97-27) GN=gu... GUAA_BACHK - GMP synthase [glutamine-hydrolyzing] OS=Bacillus thuringiensis subsp. konkukian GN=guaA PE=3 SV=1	0.0	[1..515]	[1..515]
GUAA_BACLD - GMP synthase [glutamine-hydrolyzing] OS=Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 250...	0.0	[10..515]	[8..513]
GUAA_BACCN - GMP synthase [glutamine-hydrolyzing] OS=Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98...	0.0	[4..515]	[1..512]
gi\|254756031 - gi\|254756031\|ref\|ZP_05208062.1\| GMP synthase [Bacillus anthracis str. Vollum] gi\|167530531, gi... - gi\|167634217\|ref\|ZP_02392539.1\| GMP synthase [Bacillus anthracis str. A0442], gi\|167530531\|gb\|EDR932... gi\|254761681 - gi\|254761681\|ref\|ZP_05213699.1\| GMP synthase [Bacillus anthracis str. Australia 94] GUAA_BACC0 - GMP synthase [glutamine-hydrolyzing] OS=Bacillus cereus (strain AH820) GN=guaA PE=3 SV=1 gi\|254735439 - gi\|254735439\|ref\|ZP_05193147.1\| GMP synthase [Bacillus anthracis str. Western North America USA6153] gi\|254744183 - gi\|254744183\|ref\|ZP_05201865.1\| GMP synthase [Bacillus anthracis str. Kruger B] gi\|47777798, gi\|... - gi\|47777798\|ref\|YP_016877.2\| bifunctional GMP synthase/glutamine amidotransferase protein [Bacillus ... gi\|30253765, gi\|... - gi\|30260444\|ref\|NP_842821.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Bacillus ... gi\|21398215 - ref\|NP_654200.1\| GMP_synt_C, GMP synthase C terminal domain [Bacillus anthracis str. A2012] gi\|254686663 - gi\|254686663\|ref\|ZP_05150521.1\| GMP synthase [Bacillus anthracis str. CNEVA-9066] gi\|254724731 - gi\|254724731\|ref\|ZP_05186514.1\| GMP synthase [Bacillus anthracis str. A1055] GUAA_BACAN - GMP synthase [glutamine-hydrolyzing] OS=Bacillus anthracis GN=guaA PE=3 SV=1	0.0	[4..515]	[1..512]
GUAA_BACC1 - GMP synthase [glutamine-hydrolyzing] OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=guaA PE=3 S...	0.0	[4..515]	[1..512]
GUAA_LACAC - GMP synthase [glutamine-hydrolyzing] OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 /... GUAA_LACAC - GMP synthase [glutamine-hydrolyzing] OS=Lactobacillus acidophilus GN=guaA PE=3 SV=1 gi\|227869121, gi... - gi\|227903135\|ref\|ZP_04020940.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Lactob...	0.0	[1..515]	[1..516]
GUAA_BACHD - Putative GMP synthase [glutamine-hydrolyzing] OS=Bacillus halodurans GN=guaA PE=3 SV=1 GUAA_BACHD - Putative GMP synthase [glutamine-hydrolyzing] OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 1819...	0.0	[10..515]	[8..513]

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Predicted Domain #1

Region A:
Residues: [1-515]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIILKKQHDT IIVLDFGSQY NQLIARRIRE FGVYSELHPH TITAEEIKAM NPKGIIFSGG  60
   61 PNSVYGEGAL HCDEKIFDLG LPIFGICYGM QLMTQQFGGT VERANHREYG KAVLKVENES 120
  121 KLYANLPEEQ VVWMSHGDLV TGLPEGFVVD ATSESCPIAG MSNEAKNLYG VQFHPEVRHS 180
  181 EHGNDLIKNF VFGVCGCSEG WNMENFIEVE LEKIRETVGD KKVLCALSGG VDSSVVAVLI 240
  241 HKAIGDQLTC IFVDHGLLRK GEAEGVMKTF SEGFHMNVIK VDAKERFMNK LKGVEDPEQK 300
  301 RKIIGNEFIY VFDDEASKLE GMDFLAQGTL YTDIVESGTA TAQTIKSHHN VGGLPEDMQF 360
  361 KLIEPLNTLF KDEVRVLGSE LGIPDEIVWR QPFPGPGLGI RVLGEITEEK LEIVRESDAI 420
  421 LREEIIKAGL DREIWQYFTA LPGMRSVGVM GDERTYDYTV GIRAVTSIDG MTADWARIPW 480
  481 DVLEKISVRI VNEVKHVNRI VYDVTSKPPA TIEWE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	145.0
Match:	1gpmA
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
4-amino-4-deoxychorismate synthase activity	4.48164623771604	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	3.18611223446294	bayes_pls_golite062009
anthranilate synthase activity	2.51214170411838	bayes_pls_golite062009
GMP synthase activity	2.47512732878183	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	2.18904295741925	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	2.1085073706117	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	2.08576594192788	bayes_pls_golite062009
phosphoribosylformylglycinamidine synthase activity	1.83575136996743	bayes_pls_golite062009
GMP synthase (glutamine-hydrolyzing) activity	1.81483405404572	bayes_pls_golite062009
ligase activity	1.7997907410336	bayes_pls_golite062009
oxo-acid-lyase activity	1.35896725827905	bayes_pls_golite062009
catalytic activity	0.828867994386867	bayes_pls_golite062009
asparagine synthase (glutamine-hydrolyzing) activity	0.3673193848392	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.270391651600004	bayes_pls_golite062009
carbon-carbon lyase activity	0.0769356405014503	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: