YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|224503276
Organism:	Listeria monocytogenes FSL R2-561
Length:	312 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|224503276.

Description	E-value	Query Range	Subject Range
HPRK_LISIN - HPr kinase/phosphorylase OS=Listeria innocua GN=hprK PE=3 SV=1 HPRK_LISIN - HPr kinase/phosphorylase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=hprK PE=3 SV=1	417.0	[0..1]	[312..1]
gi\|47569263, gi\|... - gi\|47569263\|ref\|ZP_00239948.1\| Hpr(ser) kinase/phosphatase [Bacillus cereus G9241], gi\|47554034\|gb\|E...	407.0	[0..4]	[305..48]
gi\|42740244, gi\|... - gi\|42784313\|ref\|NP_981560.1\| HPr kinase/phosphorylase [Bacillus cereus ATCC 10987], gi\|42740244\|gb\|A...	406.0	[0..4]	[305..46]
gi\|75759648, gi\|... - gi\|75759648\|ref\|ZP_00739732.1\| HPR(SER) KINASE / PHOSPHATASE [Bacillus thuringiensis serovar israel...	406.0	[0..4]	[305..46]
gi\|227535584, gi... - gi\|227535584\|ref\|ZP_03965633.1\| HPr kinase [Lactobacillus paracasei subsp. paracasei ATCC 25302], gi... HPRK_LACCA - HPr kinase/phosphorylase OS=Lactobacillus casei GN=hprK PE=1 SV=1 HPRK_LACC3 - HPr kinase/phosphorylase OS=Lactobacillus casei (strain ATCC 334) GN=hprK PE=3 SV=1 gi\|224453415, gi... - gi\|239631201\|ref\|ZP_04674232.1\| HPr kinase/phosphorylase kinase/phosphorylase [Lactobacillus paracas... HPRK_LACCB - HPr kinase/phosphorylase OS=Lactobacillus casei (strain BL23) GN=hprK PE=3 SV=1 gi\|6688477 - gi\|6688477\|emb\|CAB65151.1\| HprK protein [Lactobacillus casei subsp. casei ATCC 393]	405.0	[0..1]	[312..1]
HPRK_LACJO - HPr kinase/phosphorylase OS=Lactobacillus johnsonii GN=hprK PE=3 SV=1 HPRK_LACJO - HPr kinase/phosphorylase OS=Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) GN=hprK PE...	402.0	[0..1]	[312..1]
gi\|228930162, gi... - gi\|228930162\|ref\|ZP_04093171.1\| HPr kinase/phosphorylase [Bacillus thuringiensis serovar pondicherie... gi\|228917766, gi... - gi\|228917766\|ref\|ZP_04081306.1\| HPr kinase/phosphorylase [Bacillus thuringiensis serovar pulsiensis ... gi\|228948879, gi... - gi\|228948879\|ref\|ZP_04111154.1\| HPr kinase/phosphorylase [Bacillus thuringiensis serovar monterrey B... gi\|228936446, gi... - gi\|228936446\|ref\|ZP_04099244.1\| HPr kinase/phosphorylase [Bacillus thuringiensis serovar andalousien... gi\|228596075, gi... - gi\|229187371\|ref\|ZP_04314514.1\| HPr kinase/phosphorylase [Bacillus cereus BGSC 6E1], gi\|228596075\|gb... gi\|228658762, gi... - gi\|229124667\|ref\|ZP_04253848.1\| HPr kinase/phosphorylase [Bacillus cereus 95/8201], gi\|228658762\|gb\|... gi\|65317134 - gi\|65317134\|ref\|ZP_00390093.1\| COG1493: Serine kinase of the HPr protein, regulates carbohydrate met...	402.0	[0..4]	[305..28]
gi\|254997674 - gi\|254997674\|dbj\|BAH88275.1\| HPr(serine) kinase/phosphatase [Streptococcus mutans NN2025] HPRK_STRMU - HPr kinase/phosphorylase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) GN=hprK PE=... HPRK_STRMU - HPr kinase/phosphorylase OS=Streptococcus mutans GN=hprK PE=3 SV=1	402.0	[0..4]	[312..2]
HPRK_STRA3 - HPr kinase/phosphorylase OS=Streptococcus agalactiae serotype III GN=hprK PE=3 SV=1 HPRK_STRA3 - HPr kinase/phosphorylase OS=Streptococcus agalactiae serotype III (strain NEM316) GN=hprK PE=3 SV=1 HPRK_STRA1 - HPr kinase/phosphorylase OS=Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS7... gi\|77413083, gi\|... - gi\|77413083\|ref\|ZP_00789284.1\| HPr(Ser) kinase/phosphatase [Streptococcus agalactiae 515], gi\|771608... HPRK_STRA5 - HPr kinase/phosphorylase OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) GN=... HPRK_STRA5 - HPr kinase/phosphorylase OS=Streptococcus agalactiae serotype V GN=hprK PE=3 SV=1 gi\|77405999, gi\|... - gi\|77405999\|ref\|ZP_00783077.1\| HPr(Ser) kinase/phosphatase [Streptococcus agalactiae H36B], gi\|77175... gi\|76799873, gi\|... - gi\|76799873\|ref\|ZP_00781899.1\| HPr(Ser) kinase/phosphatase [Streptococcus agalactiae 18RS21], gi\|765... HPRK_STRA1 - HPr kinase/phosphorylase OS=Streptococcus agalactiae serotype Ia GN=hprK PE=3 SV=1 gi\|77410812, gi\|... - gi\|77410812\|ref\|ZP_00787170.1\| HPr(Ser) kinase/phosphatase [Streptococcus agalactiae CJB111], gi\|771... gi\|77172281, gi\|... - gi\|77409103\|ref\|ZP_00785818.1\| HPr(Ser) kinase/phosphatase [Streptococcus agalactiae COH1], gi\|77172...	400.0	[0..5]	[312..3]
HPRK_LACBR - (Q93TM7) HPr kinase/phosphorylase (EC 2.7.11.-) (EC 2.7.4.-) (HPrK/P) (HPr(Ser) kinase/phosphorylase... HPRK_LACBA - HPr kinase/phosphorylase OS=Lactobacillus brevis (strain ATCC 367 / JCM 1170) GN=hprK PE=3 SV=1	399.0	[0..1]	[311..1]

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Predicted Domain #1

Region A:
Residues: [1-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSVTVKDL KERLNLELIC SETGLERPIS TSDLSRPGLE LTGFFSYYPE DRVQLFGMTE  60
   61 ISFSEGMEPE ERLKRYKQMC TKRTPAFVIS RNLEVPKELV AAAKEADIPV LRSRLKTTRL 120
  121 SVYITNYLES RLAPVISMHG VLVDIYGLGV LITGSSGVGK SETALELVKR GHRLVADDNV 180
  181 EIRQEDEMTL IGSSPAIIEH LLEIRGLGII NVMTLFGAGA VRSSKKITIV VHLENWDPDK 240
  241 HYDRVGLDQE KTKIFDMDIP KITVPVRPGR NLSVIIEVAA MNFRLKNMGY NAAEQFTQDL 300
  301 NNLIGHNSSM ND

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.0
Match:	1ko7A
Description:	HPr kinase/phoshatase HprK N-terminal domain; HPr kinase HprK C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.96595957357027	bayes_pls_golite062009
phosphoenolpyruvate carboxykinase activity	0.895807668315489	bayes_pls_golite062009
carbon-carbon lyase activity	0.626079896377643	bayes_pls_golite062009
lyase activity	0.600389586904626	bayes_pls_golite062009
carboxy-lyase activity	0.593189334075365	bayes_pls_golite062009
binding	0.456582751079595	bayes_pls_golite062009
phosphoenolpyruvate carboxykinase (ATP) activity	0.0272102212862302	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: