YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|168797146, gi...
Organism:	Escherichia coli O157:H7 str. EC508
Length:	457 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|168797146, gi....

Description	E-value	Query Range	Subject Range
gi\|77962694, gi\|... - gi\|77962694\|ref\|ZP_00826511.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia mollaretii ATCC 439...	494.0	[0..1]	[456..1]
CYSG_SHIB3 - Siroheme synthase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=cysG PE=3 SV=1 CYSG_SHIBS - Siroheme synthase OS=Shigella boydii serotype 4 (strain Sb227) GN=cysG PE=3 SV=1	490.0	[0..1]	[457..1]
CYSG_ECO24 - Siroheme synthase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=cysG PE=3 SV=1 CYSG_ECOSE - Siroheme synthase OS=Escherichia coli (strain SE11) GN=cysG PE=3 SV=1 CYSG_ECO8A - Siroheme synthase OS=Escherichia coli O8 (strain IAI1) GN=cysG PE=3 SV=1	489.0	[0..1]	[457..1]
gi\|24053835, gi\|... - gi\|24114633\|ref\|NP_709143.1\| siroheme synthase [Shigella flexneri 2a str. 301], gi\|24053835\|gb\|AAN44... CYSG_SHIF8 - Siroheme synthase OS=Shigella flexneri serotype 5b (strain 8401) GN=cysG PE=3 SV=1 gi\|30065346, gi\|... - gi\|30065346\|ref\|NP_839517.1\| siroheme synthase [Shigella flexneri 2a str. 2457T], gi\|30043608\|gb\|AAP... CYSG_SHISS - Siroheme synthase OS=Shigella sonnei (strain Ss046) GN=cysG PE=3 SV=1 CYSG_SHIFL - Siroheme synthase OS=Shigella flexneri GN=cysG PE=3 SV=1	489.0	[0..1]	[457..1]
CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis GN=cysG2 PE=3 SV=1 CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=cysG2 PE=3 SV=1 gi\|170022493, gi... - gi\|170022493\|ref\|YP_001718998.1\| siroheme synthase [Yersinia pseudotuberculosis YPIII], gi\|169749027... CYSG2_YERP3 - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=cysG2 PE=3 SV=...	489.0	[0..1]	[456..1]
CYSG_ECO45 - Siroheme synthase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=cysG PE=3 SV=1 CYSG_ECOK1 - Siroheme synthase OS=Escherichia coli O1:K1 / APEC GN=cysG PE=3 SV=1 CYSG_ECOUT - Siroheme synthase OS=Escherichia coli (strain UTI89 / UPEC) GN=cysG PE=3 SV=1 gi\|226902365, gi... - gi\|237703101\|ref\|ZP_04533582.1\| siroheme synthase [Escherichia sp. 3_2_53FAA], gi\|226902365\|gb\|EEH88...	488.0	[0..1]	[457..1]
CYSG_ECOL5 - Siroheme synthase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=cysG PE=3 SV=1 gi\|191171534, gi... - gi\|75241536\|ref\|ZP_00725381.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli F11], gi\|19...	488.0	[0..1]	[457..1]
CYSG_ECOL6 - Siroheme synthase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=cysG PE=3 SV=1 CYSG_ECO27 - Siroheme synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=cysG PE=3 SV=1 sp\|B7UK79\|CYSG_ECO27 - Siroheme synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=cysG PE=3 SV=1 gi\|227883504, gi... - gi\|227883504\|ref\|ZP_04001309.1\| siroheme synthase [Escherichia coli 83972], gi\|227839383\|gb\|EEJ49849... CYSG_ECOL6 - Siroheme synthase OS=Escherichia coli O6 GN=cysG PE=3 SV=1	488.0	[0..1]	[457..1]
gi\|606302\|gb\|AAA... - CG Site No. 893 [Escherichia coli] gi\|606302 - gi\|606302\|gb\|AAA58165.1\| CG Site No. 893 [Escherichia coli]	486.0	[0..1]	[457..1]
gi\|192957849, gi... - gi\|75236970\|ref\|ZP_00721026.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli E110019], g...	486.0	[0..1]	[457..1]

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Predicted Domain #1

Region A:
Residues: [1-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHLPIFCQL RDRDCLIVGG GDVAERKARL LLDAGARLTV NALAFIPQFT AWADAGMLTL  60
   61 VEGPFDESLL DTCWLAIAAT DDDALNQRVS EAAEARRIFC NVVDAPKAAS FIMPSIIDRS 120
  121 PLMVAVSSGG TSPVLARLLR EKLESLLPLH LGQVAKYAGQ LRGRVKQQFA TMGERRRFWE 180
  181 KLFVNDRLAQ SLANNDQKAI TETTEQLINE PLDHRGEVVL VGAGPGDAGL LTLKGLQQIQ 240
  241 QADVVVYDRL VSDDIMNLVR RDADRVFVGK RAGYHCVPQE EINQILLREA QKGKRVVRLK 300
  301 GGDPFIFGRG GEELETLCNA GIPFSVVPGI TAASGCSAYS GIPLTHRDYA QSVRLITGHL 360
  361 KTGGELDWEN LAAEKQTLVF YMGLNQAATI QQKLIEHGMP GEMPVAIVEN GTAVTQRVID 420
  421 GTLTQLGELA QQMNSPSLII IGRVVGLRDK LNWFSNH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	134.0
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.573271502205	bayes_pls_golite062009
C-methyltransferase activity	3.35393353163232	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.18371138649366	bayes_pls_golite062009
catalytic activity	1.48349578618275	bayes_pls_golite062009
transferase activity	0.912524944496351	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.431791521097299	bayes_pls_golite062009
methyltransferase activity	0.424918406685891	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.28351517300952	bayes_pls_golite062009
uroporphyrinogen-III synthase activity	0.00871858903098705	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: