YRC Public Data Repository - Protein Structure Prediction

Protein:	GCST_YERPB
Organism:	Yersinia pseudotuberculosis PB1/+
Length:	365 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCST_YERPB.

Description	E-value	Query Range	Subject Range
GCST_YERPS - Aminomethyltransferase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=gcvT PE=3 SV=1 GCST_YERPS - Aminomethyltransferase OS=Yersinia pseudotuberculosis GN=gcvT PE=3 SV=1 GCST_YERP3 - Aminomethyltransferase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=gcvT PE=3 S...	0.0	[1..365]	[1..365]
gi\|75239248 - gi\|75239248\|ref\|ZP_00723221.1\| COG0404: Glycine cleavage system T protein (aminomethyltransferase) [... gi\|117625135, gi... - gi\|117625135\|ref\|YP_854123.1\| glycine cleavage system aminomethyltransferase T [Escherichia coli APE... gi\|110344645, gi... - gi\|110643053\|ref\|YP_670783.1\| glycine cleavage system aminomethyltransferase T [Escherichia coli 536...	0.0	[1..363]	[24..386]
sp\|B7UHV3\|GCST_ECO27 - Aminomethyltransferase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=gcvT PE=3 SV=1 gi\|190906457, gi... - gi\|191173206\|ref\|ZP_03034737.1\| glycine cleavage system T protein [Escherichia coli F11], gi\|1909064... GCST_ECO27 - Aminomethyltransferase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=gcvT PE=3 SV=1 GCST_ESCF3 - Aminomethyltransferase OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) GN=gc... GCST_ECO45 - Aminomethyltransferase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=gcvT PE=3 SV=1 GCST_ECO7I - Aminomethyltransferase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=gcvT PE=3 SV=1 gi\|229560214 - gi\|229560214\|ref\|YP_670783.2\| glycine cleavage system aminomethyltransferase T [Escherichia coli 536... gi\|229775962 - gi\|229775962\|ref\|YP_854123.2\| glycine cleavage system aminomethyltransferase T [Escherichia coli APE... GCST_ECOUT - Aminomethyltransferase OS=Escherichia coli (strain UTI89 / UPEC) GN=gcvT PE=3 SV=1 gi\|237706451, gi... - gi\|237706451\|ref\|ZP_04536932.1\| glycine cleavage system aminomethyltransferase T [Escherichia sp. 3_... gi\|226839573, gi... - gi\|254037949\|ref\|ZP_04872007.1\| glycine cleavage system aminomethyltransferase T [Escherichia sp. 1_...	0.0	[1..363]	[1..363]
GCST_ECOL6 - Aminomethyltransferase OS=Escherichia coli O6 GN=gcvT PE=3 SV=1 GCST_ECOL6 - Aminomethyltransferase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=gcvT PE=3 S... gi\|227834723, gi... - gi\|227888454\|ref\|ZP_04006259.1\| glycine cleavage system aminomethyltransferase T [Escherichia coli 8...	0.0	[1..363]	[1..363]
GCST_SHIFL - Aminomethyltransferase OS=Shigella flexneri GN=gcvT PE=3 SV=1 gi\|24053299, gi\|... - gi\|24114158\|ref\|NP_708668.1\| glycine cleavage system aminomethyltransferase T [Shigella flexneri 2a ... gi\|30042473, gi\|... - gi\|30064216\|ref\|NP_838387.1\| glycine cleavage system aminomethyltransferase T [Shigella flexneri 2a ...	0.0	[1..363]	[1..363]
GCST_SHIDS - Aminomethyltransferase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=gcvT PE=3 SV=1	0.0	[1..363]	[1..363]
GCST_ECOLC - Aminomethyltransferase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=gcvT PE=3 SV=1 gi\|75212480, gi\|... - gi\|75212480\|ref\|ZP_00712504.1\| COG0404: Glycine cleavage system T protein (aminomethyltransferase) [... gi\|253974718, gi... - gi\|254162817\|ref\|YP_003045925.1\| glycine cleavage system aminomethyltransferase T [Escherichia coli ... gi\|75227223, gi\|... - gi\|75227223\|ref\|ZP_00714023.1\| COG0404: Glycine cleavage system T protein (aminomethyltransferase) [... gi\|253323298, gi... - gi\|254289577\|ref\|YP_003055325.1\| glycine cleavage system aminomethyltransferase T [Escherichia coli ... GCST_ECOLI - Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) - Escherichia coli gi\|193070530, gi... - gi\|75234633\|ref\|ZP_00718964.1\| COG0404: Glycine cleavage system T protein (aminomethyltransferase) [... gi\|251786163, gi... - gi\|251786163\|ref\|YP_003000467.1\| hypothetical protein B21_02700 [Escherichia coli BL21], gi\|24237843... EG11442 - aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex ... gi\|193063577, gi... - gi\|75258505\|ref\|ZP_00729927.1\| COG0404: Glycine cleavage system T protein (aminomethyltransferase) [... GCST_ECOBW - Aminomethyltransferase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=gcvT PE=3 SV=1 GCST_SHIBS - Aminomethyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=gcvT PE=3 SV=1 gi\|403343, gi\|89... - gi\|89109684\|ref\|AP_003464.1\| aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein)... gi\|124502293, gi... - gi\|124526189\|ref\|ZP_01698194.1\| glycine cleavage system T protein [Escherichia coli B], gi\|124502293... EG11442 - aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex ... GCST_ECOSE - Aminomethyltransferase OS=Escherichia coli (strain SE11) GN=gcvT PE=3 SV=1 gi\|194424192, gi... - gi\|83587699\|ref\|ZP_00926326.1\| COG0404: Glycine cleavage system T protein (aminomethyltransferase) [... GCST_ECO8A - Aminomethyltransferase OS=Escherichia coli O8 (strain IAI1) GN=gcvT PE=3 SV=1 GCST_ECO24 - Aminomethyltransferase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=gcvT PE=3 SV=1 GCST_ECO55 - Aminomethyltransferase OS=Escherichia coli (strain 55989 / EAEC) GN=gcvT PE=3 SV=1 GCST_ECOHS - Aminomethyltransferase OS=Escherichia coli O9:H4 (strain HS) GN=gcvT PE=3 SV=1	0.0	[1..363]	[1..363]
GCST_SHIB3 - Aminomethyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=gcvT PE=3 SV=1	0.0	[1..363]	[1..363]
GCST_SHIF8 - Aminomethyltransferase OS=Shigella flexneri serotype 5b (strain 8401) GN=gcvT PE=3 SV=1	0.0	[1..363]	[1..363]
gi\|75515312, gi\|... - gi\|75515312\|ref\|ZP_00737496.1\| COG0404: Glycine cleavage system T protein (aminomethyltransferase) [...	0.0	[1..363]	[1..363]

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Predicted Domain #1

Region A:
Residues: [1-365]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKQTPLYDQ HVACGARMVD FHGWMMPLHY GSQIDEHHFV RQDAGMFDVS HMTIVDLHGN  60
   61 RTREFLRYLL ANDVAKLTQP GKALYTGMLN ESGGVIDDLI VYFLSEDYFR LVVNSATRDK 120
  121 DLAWISQHAE PYQVEVTVRD DLALIAVQGP QAQQKVATLL TTEQQQAIAG MKPFFGIQTG 180
  181 DLFIATTGYT GEAGYEIALP KQQVVAFWQQ LLAAGVKPAG LGARDTLRLE AGMNLYGQEM 240
  241 DEKTSPLAAN MGWTVAWQPE DRQFIGRAAL ERQRMKGTEQ LVGLIMTEKG VLRNELPVYF 300
  301 FDAAGNQHVG VITSGSFSPT LGFSIALARV PAGIGEHAVV QIRNREMPVR VTKPGFVRAG 360
  361 KAIVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	121.0
Match:	1vloA
Description:	Crystal structure of aminomethyltransferase (T protein; tetrahydrofolate-dependent) of glycine cleavage system (np417381) from Escherichia coli k12 at 1.70 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aminomethyltransferase activity	10.5654741349554	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	5.37200252580633	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	5.37200252580633	bayes_pls_golite062009
methyltransferase activity	3.28983380541263	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	3.20782575104451	bayes_pls_golite062009
catalytic activity	1.65079399897053	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	1.19783690850993	bayes_pls_golite062009
oxidoreductase activity	0.867567984371732	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors	0.550291785460228	bayes_pls_golite062009
transferase activity	0.217873555384951	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: