YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|168782939, gi...
Organism:	Escherichia coli O157:H7 str. EC4076
Length:	155 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|168782939, gi....

Description	E-value	Query Range	Subject Range
gi\|24111645, gi\|... - gi\|24111645\|ref\|NP_706155.1\| ribonuclease H [Shigella flexneri 2a str. 301], gi\|24050418\|gb\|AAN41862...	216.0	[0..1]	[155..38]
gi\|157833638, gi... - gi\|494540\|pdb\|1RBR\| Chain , Ribonuclease H (E.C.3.1.26.4) Mutant With His 62 Replaced By Pro (H62p...	216.0	[0..1]	[155..1]
gi\|26246158, gi\|... - gi\|26246158\|ref\|NP_752197.1\| ribonuclease H [Escherichia coli CFT073], gi\|26106555\|gb\|AAN78741.1\|AE0...	216.0	[0..1]	[155..38]
gi\|91070856, gi\|... - gi\|91209282\|ref\|YP_539268.1\| ribonuclease H [Escherichia coli UTI89], gi\|91070856\|gb\|ABE05737.1\| RNa... gi\|117622496, gi... - gi\|117622496\|ref\|YP_851409.1\| ribonuclease H [Escherichia coli APEC O1], gi\|115511620\|gb\|ABI99694.1\|... gi\|226899001, gi... - gi\|237707791\|ref\|ZP_04538272.1\| ribonuclease H [Escherichia sp. 3_2_53FAA], gi\|226899001\|gb\|EEH85260... gi\|194419057, gi... - gi\|194432795\|ref\|ZP_03065080.1\| ribonuclease H [Shigella dysenteriae 1012], gi\|194419057\|gb\|EDX35141...	216.0	[0..1]	[155..38]
gi\|110613810, gi... - gi\|110804262\|ref\|YP_687781.1\| ribonuclease H [Shigella flexneri 5 str. 8401], gi\|110613810\|gb\|ABF024...	216.0	[0..1]	[155..38]
gi\|75258799, gi\|... - gi\|75258799\|ref\|ZP_00730189.1\| COG0328: Ribonuclease HI [Escherichia coli E22], gi\|193063213\|ref\|ZP_... gi\|75211234, gi\|... - gi\|75211234\|ref\|ZP_00711341.1\| COG0328: Ribonuclease HI [Escherichia coli B171], gi\|194427582\|ref\|ZP... RNH_ECOHS - Ribonuclease H OS=Escherichia coli O9:H4 (strain HS) GN=rnhA PE=3 SV=1 RNH_ECO55 - Ribonuclease H OS=Escherichia coli (strain 55989 / EAEC) GN=rnhA PE=3 SV=1	213.0	[0..1]	[155..1]
sp\|B7UJB0\|RNH_ECO27 - Ribonuclease H OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=rnhA PE=3 SV=1 gi\|191171436, gi... - gi\|75241726\|ref\|ZP_00725563.1\| COG0328: Ribonuclease HI [Escherichia coli F11], gi\|191171436\|ref\|ZP_... RNH_ECOL5 - Ribonuclease H OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=rnhA PE=3 SV=1 RNH_ECO27 - Ribonuclease H OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=rnhA PE=3 SV=1	213.0	[0..1]	[155..1]
gi\|62126462, gi\|... - gi\|62178829\|ref\|YP_215246.1\| ribonuclease H [Salmonella enterica subsp. enterica serovar Choleraesui...	213.0	[0..1]	[154..120]

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Predicted Domain #1

Region A:
Residues: [1-155]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKQVEIFTD GSCLGNPGPG GYGAILRYRG REKTFSAGYT RTTNNRMELM AAIVALEALK  60
   61 EHCEVILSTD SQYVRQGITQ WIHNWKKRGW KTADKKPVKN VDLWQRLDAA LGQHQIKWEW 120
  121 VKGHAGHPEN ERCDELARAA AMNPTLEDTG YQVEV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	1rbrA
Description:	STRUCTURAL STUDY OF MUTANTS OF ESCHERICHIA COLI RIBONUCLEASE HI WITH ENHANCED THERMOSTABILITY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonuclease activity	3.91517707500372	bayes_pls_golite062009
endoribonuclease activity	3.00008907756136	bayes_pls_golite062009
ribonuclease H activity	2.37346218921366	bayes_pls_golite062009
hydrolase activity	2.30893115816458	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.26022264830742	bayes_pls_golite062009
nuclease activity	1.81796593394339	bayes_pls_golite062009
endonuclease activity	1.79009816048707	bayes_pls_golite062009
catalytic activity	1.62277843225829	bayes_pls_golite062009
exoribonuclease activity	1.48827607538468	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	1.34153791988846	bayes_pls_golite062009
3'-5'-exoribonuclease activity	0.8085201347205	bayes_pls_golite062009
exonuclease activity	0.39213900591465	bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters	0.13187450705887	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: