YRC Public Data Repository - Protein Structure Prediction

Protein:	ISPE_ECO8A
Organism:	Escherichia coli IAI1
Length:	283 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISPE_ECO8A.

Description	E-value	Query Range	Subject Range
gi\|75511756, gi\|... - gi\|75511756\|ref\|ZP_00734385.1\| COG1947: 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate syntha... ISPE_ECOHS - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O9:H4 (strain HS) GN=ispE PE=3... gi\|124528409, gi... - gi\|124528409\|ref\|ZP_01699719.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli B... ISPE_ECOLC - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 /... ISPE_ECOLU - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O17:K52:H18 (strain UMN026 / E...	279.0	[0..1]	[283..1]
ISPE_ECO45 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN... ISPE_ECOK1 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O1:K1 / APEC GN=ispE PE=3 SV=1 ISPE_ECO81 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O81 (strain ED1a) GN=ispE PE=3... gi\|75242012 - gi\|75242012\|ref\|ZP_00725806.1\| COG1947: 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate syntha... gi\|237705170, gi... - gi\|237705170\|ref\|ZP_04535651.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia sp. 3_... ISPE_ECOUT - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli (strain UTI89 / UPEC) GN=ispE ... ISPE_ECOL5 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC)...	278.0	[0..1]	[283..1]
gi\|253773793, gi... - gi\|254288098\|ref\|YP_003053846.1\| 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Escherichia coli... gi\|251784714, gi... - gi\|251784714\|ref\|YP_002999018.1\| hypothetical protein B21_01193 [Escherichia coli BL21], gi\|24237698... gi\|254161290, gi... - gi\|254161290\|ref\|YP_003044398.1\| 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Escherichia coli... gi\|194424013, gi... - gi\|83587352\|ref\|ZP_00925980.1\| COG1947: 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate syntha...	277.0	[0..1]	[283..1]
gi\|193066746, gi... - gi\|75255056\|ref\|ZP_00726961.1\| COG1947: 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate syntha...	277.0	[0..1]	[283..1]
gi\|15801437, gi\|... - gi\|15801437\|ref\|NP_287454.1\| 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Escherichia coli O15... gi\|25338420 - gi\|25338420\|pir\|\|F85700 hypothetical protein ychB [imported] - Escherichia coli (strain O157:H7, su...	277.0	[0..1]	[283..1]
gi\|254792678, gi... - gi\|254792678\|ref\|YP_003077515.1\| 4-diphosphocytidyl-2-C-methylerythritol kinase [Escherichia coli O1... EG11294 - 4-diphosphocytidyl-2-C-methylerythritol kinase / 4-diphosphocytidyl-2-C-methylerythritol kinase; iso... gi\|217318802, gi... - gi\|217328375\|ref\|ZP_03444457.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli O... gi\|168802112, gi... - gi\|189375856\|gb\|EDU94272.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli O157:... gi\|168787712, gi... - gi\|189372525\|gb\|EDU90941.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli O157:... gi\|189000058, gi... - gi\|189000058\|gb\|EDU69044.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli O157:... gi\|168771097, gi... - gi\|189360068\|gb\|EDU78487.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli O157:... ISPE_ECO5E - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)... gi\|208815028, gi... - gi\|208815028\|ref\|ZP_03256207.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli O... gi\|195939096 - gi\|195939096\|ref\|ZP_03084478.1\| 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Escherichia coli ... ISPE_ECODH - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli (strain K12 / DH10B) GN=ispE P... gi\|7527350, gi\|4... - gi\|89108053\|ref\|AP_001833.1\| 4-diphosphocytidyl-2-C-methylerythritol kinase [Escherichia coli str. K... gi\|15830967, gi\|... - gi\|15830967\|ref\|NP_309740.1\| 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Escherichia coli O15... gi\|168764418, gi... - gi\|189365593\|gb\|EDU84009.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli O157:... ISPE_ECOLI - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) (CMK) (4-(cytidine-5'-diphospho)-2-... gi\|188015083, gi... - gi\|188015083\|gb\|EDU53205.1\| 4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Escherichia coli O157:... ISPE_ECO57 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O157:H7 GN=ispE PE=3 SV=1 EG11294 - 4-diphosphocytidyl-2-C-methylerythritol kinase / 4-diphosphocytidyl-2-C-methylerythritol kinase; iso... ISPE_ECOBW - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli (strain K12 / MC4100 / BW2952)...	277.0	[0..1]	[283..1]
ISPE_SHIDS - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Shigella dysenteriae serotype 1 (strain Sd197) ...	277.0	[0..1]	[283..1]
gi\|75212646 - gi\|75212646\|ref\|ZP_00712644.1\| COG1947: 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate syntha...	276.0	[0..1]	[283..1]
gi\|227836574, gi... - gi\|227886370\|ref\|ZP_04004175.1\| 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Escherichia coli ... ISPE_ECOL6 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O6 GN=ispE PE=1 SV=1 ISPE_ECOL6 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 70...	276.0	[0..1]	[283..1]
gi\|34810607, gi\|... - gi\|34810607\|pdb\|1OJ4\|B Chain B, Ternary Complex Of 4-Diphosphocytidyl-2-C-Methyl-D- Erythritol Kinas...	270.0	[0..5]	[283..5]

Back

Predicted Domain #1

Region A:
Residues: [1-283]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTQWPSPAK LNLFLYITGQ RADGYHTLQT LFQFLDYGDT ISIELRDDGD IRLLTPVEGV  60
   61 EHEDNLIVRA ARLLMKTAAD SGRLPTGSGA NISIDKRLPM GGGLGGGSSN AATVLVALNH 120
  121 LWQCGLSMDE LAEMGLTLGA DVPVFVRGHA AFAEGVGEIL TPVDPPEKWY LVAHPGVSIP 180
  181 TPVIFKDPEL PRNTPKRSIE TLLKCEFSND CEVIARKRFR EVDAVLSWLL EYAPSRLTGT 240
  241 GACVFAEFDT ESEARQVLEQ APEWLNGFVA KGVNLSPLHR AML

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.045757
Match:	1oj4A
Description:	Ternary complex of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity	1.9881460462076	bayes_pls_golite062009
catalytic activity	1.20658247466773	bayes_pls_golite062009
diphosphomevalonate decarboxylase activity	1.0502744466494	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: