YRC Public Data Repository - Protein Structure Prediction

Protein:	CYSG_SALTI
Organism:	Salmonella typhi
Length:	457 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYSG_SALTI.

Description	E-value	Query Range	Subject Range
CYSG_SHIB3 - Siroheme synthase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=cysG PE=3 SV=1 CYSG_SHIBS - Siroheme synthase OS=Shigella boydii serotype 4 (strain Sb227) GN=cysG PE=3 SV=1	0.0	[1..457]	[1..457]
CYSG_ECO24 - Siroheme synthase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=cysG PE=3 SV=1 CYSG_ECOSE - Siroheme synthase OS=Escherichia coli (strain SE11) GN=cysG PE=3 SV=1 CYSG_ECO8A - Siroheme synthase OS=Escherichia coli O8 (strain IAI1) GN=cysG PE=3 SV=1	0.0	[1..457]	[1..457]
gi\|24053835, gi\|... - gi\|24114633\|ref\|NP_709143.1\| siroheme synthase [Shigella flexneri 2a str. 301], gi\|24053835\|gb\|AAN44... CYSG_SHIF8 - Siroheme synthase OS=Shigella flexneri serotype 5b (strain 8401) GN=cysG PE=3 SV=1 gi\|30065346, gi\|... - gi\|30065346\|ref\|NP_839517.1\| siroheme synthase [Shigella flexneri 2a str. 2457T], gi\|30043608\|gb\|AAP... CYSG_SHISS - Siroheme synthase OS=Shigella sonnei (strain Ss046) GN=cysG PE=3 SV=1 CYSG_SHIFL - Siroheme synthase OS=Shigella flexneri GN=cysG PE=3 SV=1	0.0	[1..457]	[1..457]
gi\|208726275, gi... - gi\|208806474\|ref\|ZP_03248811.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4206], gi\|2087262... CYSG_ECOSM - Siroheme synthase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=cysG PE=3 SV=1 gi\|208739702, gi... - gi\|208819579\|ref\|ZP_03259899.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4042], gi\|2087397... gi\|208733150, gi... - gi\|208811873\|ref\|ZP_03253202.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4045], gi\|2087331... CYSG_ECO55 - Siroheme synthase OS=Escherichia coli (strain 55989 / EAEC) GN=cysG PE=3 SV=1 gi\|217320428, gi... - gi\|217324207\|ref\|ZP_03440291.1\| siroheme synthase [Escherichia coli O157:H7 str. TW14588], gi\|217320... gi\|193061862, gi... - gi\|75260342\|ref\|ZP_00731610.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli E22], gi\|19... gi\|189369618, gi... - gi\|189369618\|gb\|EDU88034.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4501], gi\|168759399\|r... gi\|85676672, gi\|... - gi\|89110641\|ref\|AP_004421.1\| fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase/... gi\|189359351, gi... - gi\|189359351\|gb\|EDU77770.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4401], gi\|168753127\|r... gi\|187771618, gi... - gi\|187771618\|gb\|EDU35462.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4196], gi\|168772734\|r... CYSG_ECOLC - Siroheme synthase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=cysG PE=3 SV=1 gi\|168765722, gi... - gi\|189364751\|gb\|EDU83170.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4486], gi\|168765722\|r... gi\|189374423, gi... - gi\|189374423\|gb\|EDU92839.1\| siroheme synthase [Escherichia coli O157:H7 str. EC869], gi\|168785179\|re... gi\|189002542, gi... - gi\|189002542\|gb\|EDU71528.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4076], gi\|168779458\|r... CYSG_ECODH - Siroheme synthase OS=Escherichia coli (strain K12 / DH10B) GN=cysG PE=3 SV=1 gi\|168797146, gi... - gi\|189380160\|gb\|EDU98576.1\| siroheme synthase [Escherichia coli O157:H7 str. EC508], gi\|168797146\|re... gi\|194439502, gi... - gi\|83585121\|ref\|ZP_00923773.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli 101-1], gi\|... CYSG_ECOHS - Siroheme synthase OS=Escherichia coli O9:H4 (strain HS) GN=cysG PE=3 SV=1 gi\|75211735, gi\|... - gi\|75211735\|ref\|ZP_00711799.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli B171], gi\|1... gi\|191168412, gi... - gi\|75228409\|ref\|ZP_00715055.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli B7A], gi\|19... CYSG_ECOBW - Siroheme synthase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=cysG PE=3 SV=1 CYSG_ECO57 - Siroheme synthase OS=Escherichia coli O157:H7 GN=cysG PE=3 SV=1 gi\|242378894, gi... - gi\|251786621\|ref\|YP_003000925.1\| hypothetical protein B21_03171 [Escherichia coli BL21], gi\|24237889... gi\|253322849, gi... - gi\|254290046\|ref\|YP_003055794.1\| fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogen... gi\|12517996, gi\|... - gi\|15803881\|ref\|NP_289916.1\| siroheme synthase [Escherichia coli O157:H7 EDL933], gi\|12517996\|gb\|AAG... gi\|226839038, gi... - gi\|254038532\|ref\|ZP_04872588.1\| siroheme synthase [Escherichia sp. 1_1_43], gi\|226839038\|gb\|EEH71061... EG10188 - fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase /u... gi\|254163296, gi... - gi\|254163296\|ref\|YP_003046404.1\| fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogen... gi\|254594692, gi... - gi\|254795292\|ref\|YP_003080129.1\| fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogen... EG10188 - fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase /u... gi\|13363692, gi\|... - gi\|15833473\|ref\|NP_312246.1\| siroheme synthase [Escherichia coli O157:H7 str. Sakai], gi\|13363692\|db... CYSG_ECOLI - Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107) (Urogen III met... gi\|168751811, gi... - gi\|188014206\|gb\|EDU52328.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4113], gi\|168751811\|r...	0.0	[1..457]	[1..457]
CYSG_ECO45 - Siroheme synthase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=cysG PE=3 SV=1 CYSG_ECOK1 - Siroheme synthase OS=Escherichia coli O1:K1 / APEC GN=cysG PE=3 SV=1 CYSG_ECOUT - Siroheme synthase OS=Escherichia coli (strain UTI89 / UPEC) GN=cysG PE=3 SV=1 gi\|226902365, gi... - gi\|237703101\|ref\|ZP_04533582.1\| siroheme synthase [Escherichia sp. 3_2_53FAA], gi\|226902365\|gb\|EEH88...	0.0	[1..457]	[1..457]
CYSG_ECOL5 - Siroheme synthase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=cysG PE=3 SV=1 gi\|191171534, gi... - gi\|75241536\|ref\|ZP_00725381.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli F11], gi\|19...	0.0	[1..457]	[1..457]
CYSG_ECOL6 - Siroheme synthase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=cysG PE=3 SV=1 CYSG_ECO27 - Siroheme synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=cysG PE=3 SV=1 sp\|B7UK79\|CYSG_ECO27 - Siroheme synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=cysG PE=3 SV=1 gi\|227883504, gi... - gi\|227883504\|ref\|ZP_04001309.1\| siroheme synthase [Escherichia coli 83972], gi\|227839383\|gb\|EEJ49849... CYSG_ECOL6 - Siroheme synthase OS=Escherichia coli O6 GN=cysG PE=3 SV=1	0.0	[1..457]	[1..457]
gi\|606302\|gb\|AAA... - CG Site No. 893 [Escherichia coli] gi\|606302 - gi\|606302\|gb\|AAA58165.1\| CG Site No. 893 [Escherichia coli]	0.0	[1..457]	[1..457]
gi\|192957849, gi... - gi\|75236970\|ref\|ZP_00721026.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli E110019], g...	0.0	[1..457]	[1..457]
CYSG_SHIDS - Siroheme synthase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=cysG PE=3 SV=1	0.0	[1..457]	[1..457]

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Predicted Domain #1

Region A:
Residues: [1-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHLPIFCQL RDRDCLIVGG GDVAERKARL LLEAGARLTV NALTFIPQFT VWVNEGMLTL  60
   61 VEGPFDETLL DSCWLAIAAT DDDTVNQRVS EAAESRRIFC NVVDAPKAAS FIMPSIIDRS 120
  121 PLMVAVSSGG TSPVLARLLR EKLESLLPQH LGQVARYAGQ LRARVKKQFA TMGERRRFWE 180
  181 KFFVNDRLAQ SLANADEKAV NATTEHLFSE PLDHRGEVVL VGAGPGDAGL LTLKGLQQIQ 240
  241 QADIVVYDRL VSDDIMNLVR RDADRVFVGK RAGYHCVPQE EINQILLREA QKGKRVVRLK 300
  301 GGDPFIFGRG GEELETLCHA GIPFSVVPGI TAASGCSAYS GIPLTHRDYA QSVRLVTGHL 360
  361 KTGGELDWEN LAAEKQTLVF YMGLNQAATI QEKLIAFGME ANMPVALVEN GTSVKQRVVH 420
  421 GVLTQLGELA QQVESPALII VGRVVALRDK LNWFSNH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	135.0
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.573271502205	bayes_pls_golite062009
C-methyltransferase activity	3.35393353163232	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.18371138649366	bayes_pls_golite062009
catalytic activity	1.48349578618275	bayes_pls_golite062009
transferase activity	0.912524944496351	bayes_pls_golite062009
binding	0.591538530271277	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.463693177369635	bayes_pls_golite062009
methyltransferase activity	0.454156823400351	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.323461631906645	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009
protein binding	0.0615599502226839	bayes_pls_golite062009
uroporphyrinogen-III synthase activity	0.00871858903098705	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: