YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|31615957
Organism:	Homo sapiens
Length:	285 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|31615957.

Description	E-value	Query Range	Subject Range
gi\|109106251 - gi\|109106251\|ref\|XP_001092848.1\| PREDICTED: similar to reticulon 4 receptor-like 2 [Macaca mulatta]	249.0	[0..2]	[282..275]
gi\|114665748 - gi\|114665748\|ref\|XP_523529.2\| PREDICTED: hypothetical protein [Pan troglodytes]	242.0	[0..2]	[284..443]
gi\|73995891 - gi\|73995891\|ref\|XP_543540.2\| PREDICTED: similar to reticulon 4 receptor precursor [Canis familiaris]	240.0	[0..1]	[273..382]
gi\|123987714, gi... - gi\|208965434\|dbj\|BAG72731.1\| reticulon 4 receptor [synthetic construct], gi\|123999108\|gb\|ABM87137.1\|... HGNC:18601\|MIM:6... - 4 receptor RTN4R - reticulon 4 receptor	240.0	[0..1]	[285..26]
gi\|47218374 - gi\|47218374\|emb\|CAG01895.1\| unnamed protein product [Tetraodon nigroviridis]	237.0	[0..2]	[277..47]
gi\|76672827 - gi\|76672827\|ref\|XP_873455.1\| PREDICTED: similar to reticulon 4 receptor precursor [Bos taurus]	235.0	[0..1]	[285..21]
RTN4R_RAT - Reticulon-4 receptor OS=Rattus norvegicus GN=Rtn4r PE=1 SV=2	234.0	[0..1]	[285..26]

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Predicted Domain #1

Region A:
Residues: [1-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PCPGACVCYN EPKVTTSCPQ QGLQAVPVGI PAASQRIFLH GNRISHVPAA SFRACRNLTI  60
   61 LWLHSNVLAR IDAAAFTGLA LLEQLDLSDN AQLRSVDPAT FHGLGRLHTL HLDRCGLQEL 120
  121 GPGLFRGLAA LQYLYLQDNA LQALPDDTFR DLGNLTHLFL HGNRISSVPE RAFRGLHSLD 180
  181 RLLLHQNRVA HVHPHAFRDL GRLMTLYLFA NNLSALPTEA LAPLRALQYL RLNDNPWVCD 240
  241 CRARPLWAWL QKFRGSSSEV PCSLPQRLAG RDLKRLAAND LQGCA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.69897
Match:	1oznA
Description:	Reticulon 4 receptor (Nogo-66 receptor, Ngr)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
extracellular matrix structural constituent	2.72113902188155	bayes_pls_golite062009
binding	1.87302803330255	bayes_pls_golite062009
glycosaminoglycan binding	1.28988458709664	bayes_pls_golite062009
extracellular matrix binding	0.907118880836251	bayes_pls_golite062009
protein binding	0.646159692466759	bayes_pls_golite062009
polysaccharide binding	0.61188190229906	bayes_pls_golite062009
receptor binding	0.525216740013984	bayes_pls_golite062009
pattern binding	0.389630581129679	bayes_pls_golite062009
carbohydrate binding	0.343717562511172	bayes_pls_golite062009
receptor activity	0.269916678721535	bayes_pls_golite062009
nucleic acid binding	0.246718758617065	bayes_pls_golite062009
collagen binding	0.085405748322021	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: