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View Structure Prediction Details

Protein: Zasp52-PE
Organism: Drosophila melanogaster
Length: 780 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Zasp52-PE.

Description E-value Query
Range
Subject
Range
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
665.0 [0..94] [777..557]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPQLLQIK LSRFDAQPWG FRLQGGTDFA QPLLVQKVNA GSLSEQAGLQ PGDAVVKIND  60
   61 VDVFNLRHKD AQDIVVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 1wi2A
Description: Solution structure of the PDZ domain from RIKEN cDNA 2700099C19
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of muscle 3.0482783169186 bayes_pls_golite062009
actinin binding 2.91261541242779 bayes_pls_golite062009
binding 2.4211406884996 bayes_pls_golite062009
protein binding 2.25893018754605 bayes_pls_golite062009
cytoskeletal protein binding 1.21190589781988 bayes_pls_golite062009
transporter activity 0.782216866213126 bayes_pls_golite062009
transmembrane transporter activity 0.699604120098573 bayes_pls_golite062009
PDZ domain binding 0.53069705861477 bayes_pls_golite062009
substrate-specific transporter activity 0.434921764966531 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.250590541549843 bayes_pls_golite062009
protein domain specific binding 0.15766709142367 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [78-322]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGNNFVITVQ RGGSTWRPHV TPTGNVPQPN SPYLQTVTKT SLAHKQQDSQ HIGCGYNNAA  60
   61 RPFSNGGDGG VKSIVNKQYN TPVGIYSDES IAETLSAQAE VLAGGVLGVN FKKNEKEYQG 120
  121 DRSEVLKFLR EEETGQSTPE PHSPANFYWT QSHAIGGNER RTPLHHQHQQ PQQDERIGVP 180
  181 LQSNTLAPEA THRPSLPVAP KDNEEQARQD QQEQPDPRII VLPICPGLQG PEYKAEMEAA 240
  241 AAALA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [323-486]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDQDGRPRPL AASGHPACQL CGVGIVGVFV RIKDKNLHVE CFKCATCGTS LKNQGYYNFN  60
   61 NKLYCDIHAK QAAINNPPTG TEGYVPVPIK PNTKLSASTI SSALNSHGYG GHSNGYSNGN 120
  121 STPAPAPVNQ GYARPFGAAA PKSPVSYPPQ QQQQSPRPAP GGQN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.3
Match: 1b8tA
Description: Cysteine-rich (intestinal) protein, CRP, CRIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.0300494058962 bayes_pls_golite062009
protein binding 1.20339329058617 bayes_pls_golite062009
receptor activity 1.00000843633623 bayes_pls_golite062009
transporter activity 0.893102092384062 bayes_pls_golite062009
transcription regulator activity 0.765749126324598 bayes_pls_golite062009
signal transducer activity 0.73994900849782 bayes_pls_golite062009
molecular transducer activity 0.73994900849782 bayes_pls_golite062009
transmembrane transporter activity 0.7072042577999 bayes_pls_golite062009
DNA binding 0.627205331176555 bayes_pls_golite062009
nucleic acid binding 0.535498111941008 bayes_pls_golite062009
substrate-specific transporter activity 0.489535882040485 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.256518766904171 bayes_pls_golite062009
transcription factor activity 0.0507107339846072 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [487-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYATLPRSNV GQQGRNVRYQ QQQQQQQQYN NQQKQQYRNS YPMGSNYSTP SQSPYITSNT  60
   61 NNYSSSNSYN NNNYSNYNNN NVYRGAGGKS AGAFGATSAP KRGRGILNKA AGPGVRIPLC 120
  121 NSCNVQIRGP FITALGRIWC PDHFICVNGN CRRPLQDIGF VEEKGDLYCE YCFEKYLAPT 180
  181 CSKCA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.26906680202757 bayes_pls_golite062009
nucleic acid binding 1.77387731796042 bayes_pls_golite062009
DNA binding 1.7381491427081 bayes_pls_golite062009
transcription regulator activity 1.62630932116487 bayes_pls_golite062009
protein binding 0.905022998164426 bayes_pls_golite062009
transcription factor activity 0.814337855318401 bayes_pls_golite062009
chromatin binding 0.15746460121183 bayes_pls_golite062009
signal transducer activity 0.0590340677124848 bayes_pls_golite062009
molecular transducer activity 0.0590340677124848 bayes_pls_golite062009
transcription activator activity 0.00783708928051308 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [672-714]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKIKGDCLNA IGKHFHPECF TCGQCGKIFG NRPFFLEDGN AYC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.221849
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.26906680202757 bayes_pls_golite062009
nucleic acid binding 1.77387731796042 bayes_pls_golite062009
DNA binding 1.7381491427081 bayes_pls_golite062009
transcription regulator activity 1.62630932116487 bayes_pls_golite062009
protein binding 0.905022998164426 bayes_pls_golite062009
transcription factor activity 0.814337855318401 bayes_pls_golite062009
chromatin binding 0.15746460121183 bayes_pls_golite062009
signal transducer activity 0.0590340677124848 bayes_pls_golite062009
molecular transducer activity 0.0590340677124848 bayes_pls_golite062009
transcription activator activity 0.00783708928051308 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [715-780]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EADWNELFTT KCFACGFPVE AGDRWVEALN HNYHSQCFNC TFCKQNLEGQ SFYNKGGRPF  60
   61 CKNHAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.221849
Match: 2i13A
Description: No description for 2i13A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle