YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|18655667
Organism:	Escherichia coli
Length:	291 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|18655667.

Description	E-value	Query Range	Subject Range
GPDA_LEPBL - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Leptospira borgpetersenii serovar Hardjo-bovis (stra...	204.0	[0..1]	[287..1]
GPDA_LEPBJ - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Leptospira borgpetersenii serovar Hardjo-bovis (stra...	203.0	[0..1]	[287..1]
GPDA_LEPIC - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Leptospira interrogans serogroup Icterohaemorrhagiae... GPDA_LEPIC - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Leptospira interrogans serogroup Icterohaemorrhagiae...	203.0	[0..1]	[290..1]
GPDA_LEPIN - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Leptospira interrogans serogroup Icterohaemorrhagiae... GPDA_LEPIN - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Leptospira interrogans GN=gpsA PE=3 SV=1	201.0	[0..1]	[290..1]
GPDA_THETN - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Thermoanaerobacter tengcongensis GN=gpsA PE=3 SV=1 GPDA_CALS4 - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Caldanaerobacter subterraneus subsp. tengcongensis (...	200.0	[0..1]	[285..1]
gi\|238715500, gi... - gi\|77956902\|ref\|ZP_00820975.1\| COG1893: Ketopantoate reductase [Yersinia bercovieri ATCC 43970], gi\|...	199.0	[0..1]	[291..1]
gi\|149950477, gi... - gi\|77683607\|ref\|ZP_00799054.1\| Glycerol-3-phosphate dehydrogenase (NAD(P)+) [Alkaliphilus metallired...	199.0	[0..3]	[286..6]
gi\|77974316 - gi\|77974316\|ref\|ZP_00829857.1\| COG1893: Ketopantoate reductase [Yersinia frederiksenii ATCC 33641]	198.0	[0..1]	[291..1]
gi\|221319444 - gi\|221319444\|ref\|ZP_03600738.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... gi\|221314522 - gi\|221314522\|ref\|ZP_03596327.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... GPDA_BACSU - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Bacillus subtilis (strain 168) GN=gpsA PE=3 SV=2 gi\|221323720 - gi\|221323720\|ref\|ZP_03605014.1\| NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus subti... GPDA_BACSU - Glycerol-3-phosphate dehydrogenase [NAD(P)+] OS=Bacillus subtilis GN=gpsA PE=3 SV=2	198.0	[0..2]	[285..3]
gi\|126700244, gi... - gi\|126700244\|ref\|YP_001089141.1\| glycerol-3-phosphate dehydrogenase (NAD(P)+) [Clostridium difficile...	197.0	[0..2]	[286..7]

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Predicted Domain #1

Region A:
Residues: [1-291]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKITVLGCGA LGQLWLTALC KQGHEVQGWL RVPQPYCSVN LVETDGSIFN ESLTANDPDF  60
   61 LATSDLLLVT LKAWQVSDAV KSLASTLPVT TPILLIHNGM GTIEELQNIQ QPLLMGTTTH 120
  121 AARRDGNVII HVANGITHIG PARQQDGDYS YLADILQTVL PDVAWHNNIR AELWRKLAVN 180
  181 CVINPLTAIW NCPNGELRHH PQEIMQICEE VAAVIEREGH HTSAEDLRDY VMQVIDATAE 240
  241 NISSMLQDIR ALRHTEIDYI NGFLLRRARA HGIAVPENTR LFEMVKRKES E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.221849
Match:	1yjqA
Description:	Crystal structure of ketopantoate reductase in complex with NADP+
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.16785883389468	bayes_pls_golite062009
2-dehydropantoate 2-reductase activity	1.44682222689265	bayes_pls_golite062009
oxidoreductase activity	1.13814306448308	bayes_pls_golite062009
phosphogluconate dehydrogenase (decarboxylating) activity	0.79801834612624	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.62082570014178	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.413770041372969	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	0.31234823925356	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors	0.0949940266458502	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: