YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|15825656
Organism:	Homo sapiens
Length:	128 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|15825656.

Description	E-value	Query Range	Subject Range
FGF4 - fibroblast growth factor 4 gi\|225000230, gi... - gi\|225000230\|gb\|AAI72495.1\| Fibroblast growth factor 4 [synthetic construct], gi\|162318992\|gb\|AAI563...	181.0	[0..1]	[128..79]
gi\|109105124 - gi\|109105124\|ref\|XP_001100747.1\| PREDICTED: fibroblast growth factor 4 (heparin secretory transformi... gi\|114639012 - gi\|114639012\|ref\|XP_001173970.1\| PREDICTED: fibroblast growth factor 4 [Pan troglodytes]	180.0	[0..1]	[128..79]
FGF4_BOVIN - Fibroblast growth factor 4 OS=Bos taurus GN=FGF4 PE=3 SV=1	178.0	[0..1]	[128..79]
gi\|73983565 - gi\|73983565\|ref\|XP_540801.2\| PREDICTED: similar to Fibroblast growth factor-4 precursor (FGF-4) (Hep...	178.0	[0..1]	[128..79]
FGF4A_XENLA - Fibroblast growth factor 4A OS=Xenopus laevis GN=fgf4-a PE=2 SV=1	176.0	[0..1]	[128..60]
gi\|4090567 - gi\|4090567\|gb\|AAC98812.1\| putative fibroblast growth factor-4 [Notophthalmus viridescens]	174.0	[0..1]	[128..69]
gi\|84798489, gi\|... - gi\|89191828\|ref\|NP_001001398.2\| fibroblast growth factor 6a [Danio rerio], gi\|84798489\|gb\|ABC67200.1...	173.0	[0..1]	[128..78]
gi\|47216368 - gi\|47216368\|emb\|CAG02426.1\| unnamed protein product [Tetraodon nigroviridis]	173.0	[0..1]	[128..78]

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Predicted Domain #1

Region A:
Residues: [1-128]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIKRLRRLYC NVGIGFHLQA LPDGRIGGAH ADTRDSLLEL SPVERGVVSI FGVASRFFVA  60
   61 MSSKGKLYGS PFFTDECTFK EILLPNNYNA YESYKYPGMF IALGKNGKTK KGNRVSPTMK 120
  121 VTHFLPRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.522879
Match:	1ijtA
Description:	Fibroblast growth factor 4 (FGF4)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
growth factor activity	5.6790632853895	bayes_pls_golite062009
fibroblast growth factor receptor binding	5.32138222782692	bayes_pls_golite062009
receptor binding	4.8109037277027	bayes_pls_golite062009
cytokine activity	3.06355212621053	bayes_pls_golite062009
protein binding	2.73885234721265	bayes_pls_golite062009
binding	1.9997408351526	bayes_pls_golite062009
heparin binding	1.71092312487163	bayes_pls_golite062009
pattern binding	0.839280621598109	bayes_pls_golite062009
glycosaminoglycan binding	0.62267092567268	bayes_pls_golite062009
polysaccharide binding	0.55309369051712	bayes_pls_golite062009
nerve growth factor receptor binding	0.308245352535379	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: