YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|14278250
Organism:	Homo sapiens
Length:	107 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|14278250.

Description	E-value	Query Range	Subject Range
gi\|67473772, gi\|... - gi\|67473772\|ref\|XP_652635.1\| thioredoxin [Entamoeba histolytica HM-1:IMSS], gi\|56469506\|gb\|EAL47249....	139.0	[0..1]	[101..1]
gi\|160872103, gi... - gi\|94494048\|ref\|ZP_01301251.1\| hypothetical protein Rgryl_01000578 [Rickettsiella grylli], gi\|160872...	137.0	[0..2]	[106..4]
gi\|76812139, gi\|... - gi\|76812139\|ref\|YP_333769.1\| thioredoxin 1 [Burkholderia pseudomallei 1710b], gi\|76581592\|gb\|ABA5106...	136.0	[0..4]	[106..43]
gi\|53801490 - gi\|53801490\|gb\|AAU93947.1\| thioredoxin H [Helicosporidium sp. ex Simulium jonesii]	136.0	[0..2]	[107..4]
gi\|114626146 - gi\|114626146\|ref\|XP_001142154.1\| PREDICTED: similar to Thioredoxin (ATL-derived factor) (ADF) (Surfa...	135.0	[0..3]	[106..220]
gi\|82703204, gi\|... - gi\|82703204\|ref\|YP_412770.1\| thioredoxin [Nitrosospira multiformis ATCC 25196], gi\|82411269\|gb\|ABB75...	135.0	[0..1]	[106..1]
gi\|25067747 - gi\|25067747\|gb\|AAN65341.1\| thioredoxin/transketolase fusion protein [synthetic construct]	135.0	[0..1]	[106..1]
gi\|56752273, gi\|... - gi\|56752273\|ref\|YP_172974.1\| thioredoxin [Synechococcus elongatus PCC 6301], gi\|56687232\|dbj\|BAD8045... gi\|79689 - gi\|79689\|pir\|\|A32956 thioredoxin m - Synechococcus sp THIO1_SYNE7 - Thioredoxin-1 OS=Synechococcus elongatus (strain PCC 7942) GN=trxA PE=3 SV=2	135.0	[0..1]	[106..1]
gi\|83721362, gi\|... - gi\|83721362\|ref\|YP_442739.1\| thioredoxin [Burkholderia thailandensis E264], gi\|83655187\|gb\|ABC39250....	135.0	[0..4]	[106..43]
gi\|116057647 - gi\|116057647\|emb\|CAL53850.1\| Thioredoxin (ISS) [Ostreococcus tauri]	134.0	[0..2]	[106..111]

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Predicted Domain #1

Region A:
Residues: [1-107]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGVKPVGSDP DFQPELSGAG SRLAVVKFTM RGCGPCLRIA PAFSSMSNKY PQAVFLEVDV  60
   61 HQCQGTAATN NISATPTFQF FRNKVRIDQY QGADAVGLEE KIKQHLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.0
Match:	1gh2A
Description:	Thioredoxin-like protein, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	4.29032820056336	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.87994934982014	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.33295508041105	bayes_pls_golite062009
peroxidase activity	3.33295508041105	bayes_pls_golite062009
peroxiredoxin activity	3.22488012813429	bayes_pls_golite062009
thioredoxin peroxidase activity	3.15244244702443	bayes_pls_golite062009
glutathione peroxidase activity	2.53094169675712	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	2.3913606099687	bayes_pls_golite062009
protein disulfide isomerase activity	2.3913606099687	bayes_pls_golite062009
protein-disulfide reductase activity	2.24066563461479	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	2.18667085747706	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.32651538800969	bayes_pls_golite062009
disulfide oxidoreductase activity	1.07184913651636	bayes_pls_golite062009
binding	0.828696005067827	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
protein disulfide oxidoreductase activity	0.44918717550973	bayes_pls_golite062009
transferase activity	0.245320538630117	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: