YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|6730502
Organism:	Homo sapiens
Length:	176 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|6730502.

Description	E-value	Query Range	Subject Range
gi\|67908812, gi\|... - gi\|91787519\|ref\|YP_548471.1\| methylated-DNA--protein-cysteine methyltransferase [Polaromonas sp. JS6...	197.0	[0..1]	[174..1]
OGT_METAC - Methylated-DNA--protein-cysteine methyltransferase OS=Methanosarcina acetivorans GN=ogt PE=3 SV=1 OGT_METAC - Methylated-DNA--protein-cysteine methyltransferase OS=Methanosarcina acetivorans (strain ATCC 35395 ...	195.0	[0..7]	[173..1]
gi\|84693218, gi\|... - gi\|84715394\|ref\|ZP_01022495.1\| Methylated-DNA-(protein)-cysteine S-methyltransferase [Polaromonas na...	195.0	[0..1]	[174..1]
gi\|27359161, gi\|... - gi\|27367589\|ref\|NP_763116.1\| methylated DNA-protein cysteine methyltransferase [Vibrio vulnificus CM...	192.0	[0..8]	[172..3]
gi\|88780111, gi\|... - gi\|88797242\|ref\|ZP_01112832.1\| methylated-DNA-protein-cysteine S-methyltransferase [Reinekea sp. MED...	192.0	[0..7]	[173..2]
gi\|2935421 - gi\|2935421\|gb\|AAC25987.1\| adaptive response regulatory protein [Pseudoalteromonas sp. S9]	192.0	[0..2]	[176..181]
gi\|25286136 - pir\|\|E83777 O6-methylguanine DNA alkyltransferase dat [imported] - Bacillus halodurans (strain C-125... gi\|15613584, gi\|... - gi\|15613584\|ref\|NP_241887.1\| O6-methylguanine DNA alkyltransferase [Bacillus halodurans C-125], gi\|1...	190.0	[0..1]	[174..1]
OGT_METBF - Methylated-DNA--protein-cysteine methyltransferase OS=Methanosarcina barkeri (strain Fusaro / DSM 80...	190.0	[0..7]	[172..1]
gi\|75854423, gi\|... - gi\|75854423\|ref\|ZP_00762117.1\| COG0350: Methylated DNA-protein cysteine methyltransferase [Vibrio sp...	190.0	[0..1]	[172..1]
gi\|37200236, gi\|... - gi\|37675697\|ref\|NP_936093.1\| methylated DNA-protein cysteine methyltransferase [Vibrio vulnificus YJ...	189.0	[0..8]	[172..3]

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Predicted Domain #1

Region A:
Residues: [1-176]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM  60
   61 QCTAWLNAYF HQPEAIEEFP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL 120
  121 AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.154902
Match:	1yfhA
Description:	wt Human O6-Alkylguanine-DNA Alkyltransferase Bound To DNA Containing an Alkylated Cytosine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methylated-DNA-[protein]-cysteine S-methyltransferase activity	3.81641972619245	bayes_pls_golite062009
S-methyltransferase activity	2.66007025371147	bayes_pls_golite062009
catalytic activity	1.90838528948382	bayes_pls_golite062009
binding	1.9004221787372	bayes_pls_golite062009
DNA binding	1.54553435062678	bayes_pls_golite062009
nucleic acid binding	1.49720271661049	bayes_pls_golite062009
transcription regulator activity	1.28772079869532	bayes_pls_golite062009
transferase activity	1.22815682532854	bayes_pls_golite062009
methyltransferase activity	1.14625481859451	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.13184530961695	bayes_pls_golite062009
transcription factor activity	0.99095733801135	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: