YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|12084547
Organism:	Homo sapiens
Length:	219 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|12084547.

Description	E-value	Query Range	Subject Range
gi\|16973677 - gi\|16973677\|gb\|AAL32368.1\| MPG protein [Mus musculus]	313.0	[0..3]	[218..47]
gi\|50755944 - gi\|50755944\|ref\|XP_414945.1\| PREDICTED: similar to CRA36.1 (3-methyl-adenine DNA glycosylase) [Gallu...	308.0	[0..1]	[219..60]
gi\|67970037 - gi\|67970037\|dbj\|BAE01364.1\| unnamed protein product [Macaca fascicularis]	308.0	[0..1]	[219..61]
gi\|76652545 - gi\|76652545\|ref\|XP_875730.1\| PREDICTED: similar to N-methylpurine-DNA glycosylase isoform b [Bos tau...	306.0	[0..1]	[219..252]
gi\|109127093 - gi\|109127093\|ref\|XP_001118427.1\| PREDICTED: similar to N-methylpurine-DNA glycosylase isoform b [Mac...	306.0	[0..1]	[218..320]
gi\|73959875 - gi\|73959875\|ref\|XP_854372.1\| PREDICTED: similar to N-methylpurine-DNA glycosylase isoform b [Canis f...	301.0	[0..1]	[219..281]
gi\|89271995, gi\|... - gi\|89271995\|emb\|CAJ82222.1\| N-methylpurine-DNA glycosylase [Xenopus tropicalis], gi\|62857377\|ref\|NP_...	294.0	[0..7]	[216..59]
gi\|12084553, gi\|... - gi\|12084553\|pdb\|1F6O\|A Chain A, Crystal Structure Of The Human Aag Dna Repair Glycosylase Complexed ...	294.0	[0..1]	[219..1]

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Predicted Domain #1

Region A:
Residues: [1-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGHLTRLGLE FFDQPAVPLA RAFLGQVLVR RLPNGTELRG RIVETQAYLG PEDEAAHSRG  60
   61 GRQTPRNRGM FMKPGTLYVY IIYGMYFCMN ISSQGDGACV LLRALEPLEG LETMRQLRST 120
  121 LRKGTASRVL KDRELCSGPS KLCQALAINK SFDQRDLAQD EAVWLERGPL EPSEPAVVAA 180
  181 ARVGVGHAGE WARKPLRFYV RGSPWVSVVD RVAEQDTQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.69897
Match:	1f4rA
Description:	3-methyladenine DNA glycosylase (AAG, ANPG, MPG)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	2.82903690025185	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	2.47858881161269	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.38670970810513	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	1.31512600331117	bayes_pls_golite062009
catalytic activity	1.11092890710142	bayes_pls_golite062009
hydrolase activity	0.47210507650617	bayes_pls_golite062009
binding	0.0371188365761971	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: