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View Structure Prediction Details

Protein: gi|10835871
Organism: Homo sapiens
Length: 236 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|10835871.

Description E-value Query
Range
Subject
Range
gi|114627460 - gi|114627460|ref|XP_520345.2| PREDICTED: hypothetical protein [Pan troglodytes]
229.0 [0..1] [236..363]
gi|94366203 - gi|94366203|ref|XP_995211.1| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
226.0 [0..1] [236..231]
gi|68396885 - gi|68396885|ref|XP_683221.1| PREDICTED: similar to retinoid X receptor-alpha [Danio rerio]
226.0 [0..1] [236..297]
gi|83026436 - gi|83026436|gb|ABB96254.1| retinoid X receptor, alpha [Homo sapiens]
224.0 [0..1] [236..214]
gi|148747360, gi... - gi|149039209|gb|EDL93429.1| retinoid X receptor alpha, isoform CRA_a [Rattus norvegicus], gi|1487473...
224.0 [0..1] [236..229]

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Predicted Domain #1
Region A:
Residues: [1-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASPQLEELIT KVSKAHQETF PSLCQLGKYT TNSSADHRVQ LDLGLWDKFS ELATKCIIKI  60
   61 VEFAKRLPGF TGLSIADQIT LLKAACLDIL MLRICTRYTP EQDTMTFSDG LTLNRTQMHN 120
  121 AGFGPLTDLV FAFAGQLLPL EMDDTETGLL SAICLICGDR MDLEEPEKVD KLQEPLLEAL 180
  181 RLYARRRRPS QPYMFPRMLM KITDLRGIST KGAERAITLK MEIPGPMPPL IREMLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.522879
Match: 1xdkB
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.15996699473685 bayes_pls_golite062009
transcription regulator activity 0.46162010671465 bayes_pls_golite062009
protein binding 0.33427459029264 bayes_pls_golite062009
nucleic acid binding 0.15459949087509 bayes_pls_golite062009
DNA binding 0.14395376162921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle