YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|10120604, gi\|...
Organism:	Homo sapiens
Length:	302 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|10120604, gi|....

Description	E-value	Query Range	Subject Range
gi\|228746862, gi... - gi\|229014512\|ref\|ZP_04171630.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus mycoides DSM 2048], gi\|... gi\|229136162, gi... - gi\|229136162\|ref\|ZP_04264915.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus cereus BDRD-ST196], gi\|... gi\|228716294, gi... - gi\|229064993\|ref\|ZP_04200291.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus cereus AH603], gi\|22871... gi\|229170052, gi... - gi\|229170052\|ref\|ZP_04297743.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus cereus AH621], gi\|22861... gi\|163943031, gi... - gi\|89205893\|ref\|ZP_01184458.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus weihenstephanensis KBAB4...	317.0	[0..13]	[302..1]
gi\|77996551, gi\|... - gi\|78044436\|ref\|YP_360431.1\| 3-hydroxybutyryl-CoA dehydrogenase [Carboxydothermus hydrogenoformans Z...	317.0	[0..13]	[301..1]
gi\|42784519, gi\|... - gi\|42784519\|ref\|NP_981766.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus cereus ATCC 10987], gi\|427...	315.0	[0..13]	[302..1]
gi\|47553564, gi\|... - gi\|47569768\|ref\|ZP_00240440.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus cereus G9241], gi\|475535...	314.0	[0..13]	[302..1]
gi\|49480423, gi\|... - gi\|49480423\|ref\|YP_039336.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus thuringiensis serovar konk...	313.0	[0..13]	[302..1]
gi\|47530909, gi\|... - gi\|47530909\|ref\|YP_022258.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. 'Ames Ances... gi\|167635762, gi... - gi\|167635762\|ref\|ZP_02394072.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. A0442], gi\|... gi\|30260045, gi\|... - gi\|30265367\|ref\|NP_847744.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. Ames], gi\|3... gi\|164712949, gi... - gi\|165871282\|ref\|ZP_02215931.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. A0488], gi\|... gi\|21397819, gi\|... - gi\|65317321\|ref\|ZP_00390280.1\| COG1250: 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. A20... gi\|170688136, gi... - gi\|170688136\|ref\|ZP_02879347.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. A0465], gi\|... gi\|167640408, gi... - gi\|167640408\|ref\|ZP_02398672.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. A0193], gi\|... gi\|172082561, gi... - gi\|177651857\|ref\|ZP_02934440.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. A0174], gi\|... gi\|170708058, gi... - gi\|170708058\|ref\|ZP_02898506.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. A0389], gi\|... gi\|49188178, gi\|... - gi\|49188178\|ref\|YP_031431.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. Sterne], gi... gi\|190559780, gi... - gi\|190569112\|ref\|ZP_03022011.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis Tsiankovskii-I],... gi\|227818106, gi... - gi\|227818106\|ref\|YP_002818115.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. CDC 684], ... gi\|229264319, gi... - gi\|229599911\|ref\|YP_002869558.1\| 3-hydroxyacyl-CoA dehydrogenase [Bacillus anthracis str. A0248], gi... gi\|254687215 - gi\|254687215\|ref\|ZP_05151073.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. CNEVA-90... gi\|254724698 - gi\|254724698\|ref\|ZP_05186481.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. A1055] gi\|254735272 - gi\|254735272\|ref\|ZP_05192981.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. Western ... gi\|254742272 - gi\|254742272\|ref\|ZP_05199959.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. Kruger B... gi\|254755813 - gi\|254755813\|ref\|ZP_05207845.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. Vollum] gi\|254762153 - gi\|254762153\|ref\|ZP_05213999.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus anthracis str. Australi...	313.0	[0..13]	[302..1]
gi\|56421930, gi\|... - gi\|56421930\|ref\|YP_149248.1\| 3-hydroxybutyryl-CoA dehydrogenase [Geobacillus kaustophilus HTA426], g...	313.0	[0..13]	[302..1]
gi\|89271994, gi\|... - gi\|89271994\|emb\|CAJ82220.1\| short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor [Xe...	313.0	[0..4]	[302..15]
gi\|148238130, gi... - gi\|33416721\|gb\|AAH56108.1\| Hadhsc-prov protein [Xenopus laevis], gi\|148238130\|ref\|NP_001080900.1\| L-...	312.0	[0..4]	[302..15]
gi\|25283667 - pir\|\|H84124 3-hydroxybutyryl-CoA dehydrogenase mmgB [imported] - Bacillus halodurans (strain C-125) gi\|10176425, gi\|... - gi\|15616362\|ref\|NP_244667.1\| 3-hydroxybutyryl-CoA dehydrogenase [Bacillus halodurans C-125], gi\|1017...	312.0	[0..13]	[301..1]

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Predicted Domain #1

Region A:
Residues: [1-302]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSSTASASA KKIIVKHVTV IGGGLMGAGI AQVAAATGHT VVLVDQTEDI LAKSKKGIEE  60
   61 SLRKVAKKKF AENPKAGDEF VEKTLSTIAT STDAASVVHS TDLVVEAIVE NLKVKNELFK 120
  121 RLDKFAAEHT IFASNTSSLQ ITSIANATTR QDRFAGLHFF NPVPVMKLVE VIKTPMTSQK 180
  181 TFESLVDFSK ALGKHPVSCK DTPGFIVNRL LVPYLMEAIR LYERGDASKE DIDTAMKLGA 240
  241 GYPMGPFELL DYVGLDTTKF IVDGWHEMDA ENPLHQPSPS LNKLVAENKF GKKTGEGFYK 300
  301 YK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.69897
Match:	3hdhA
Description:	Short chain L-3-hydroxyacyl CoA dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.61759001796638	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.25489401408719	bayes_pls_golite062009
transporter activity	0.793769336118517	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.788034697021177	bayes_pls_golite062009
transmembrane transporter activity	0.635891484075352	bayes_pls_golite062009
binding	0.553666136934364	bayes_pls_golite062009
retinol dehydrogenase activity	0.530688665000667	bayes_pls_golite062009
phosphogluconate dehydrogenase (decarboxylating) activity	0.44449320501876	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.439912268968251	bayes_pls_golite062009
substrate-specific transporter activity	0.300373102236296	bayes_pls_golite062009
active transmembrane transporter activity	0.239024094835991	bayes_pls_golite062009
signal transducer activity	0.201915860594054	bayes_pls_golite062009
molecular transducer activity	0.201915860594054	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.165260811069909	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009
ion transmembrane transporter activity	0.0257250793986203	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: