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Protein Overview: SYT1

General Information:
Name(s) found: SYT1 / YPR095C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppressor of ypt3 mutations; member of the Sec7-domain family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1226 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: vesicle-mediated transport [IGILink to PubMed article]
    secretory pathway [IGILink to PubMed article]
    Molecular Function: ARF guanyl-nucleotide exchange factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQSISSLIK LKFLQSHSND KNGNKKGGSN VSTGIDKLRE SESYRSPFLQ LAEIQEHTNN  60
   61 DDDKLDVKEC EPTKKHSKLS RIRRKMGRLD LNFRSANEKG SEDDEILVAQ HLRNGQDPEE 120
  121 MPFKSENNID SIEKVPKPDG ERVTLTSSGS DNVKRNSKHA PFIPVKPALE KFPSSNRLSR 180
  181 DYRKSQEPTL FNGDRLVPTL PTVSRISTSS SVGSSTAASR YFNPSKRAVV ASSSSSSSSI 240
  241 KFNSLHAIPL DATPQIELAK QQDEISKRRF GRRRSRTVDV FDYINKNNTA KNKPPLSPSS 300
  301 FIRTIDEKNT NSLMQDPMGS RGPLLPDDAN IISNDTDGAE ASHPDHQVLS RSRSQSTSFV 360
  361 QGKGGKRKSI EDEGYHNKLG LPHGSGPTSV YNNKSNANST ITGMSRRSSS IVNALSSFVN 420
  421 LRSSSLSSSR QQHLQQQQQL QQKLDVSLED LPPVPAPEFS DSCKDFLIKL APYGKFIGII 480
  481 LTEKDDEFKK NCLNYLLTNC FEFKNDPLDI ALRKLLMFLE LPKETQQIDR LIMAFSFAYY 540
  541 KAQKSYSKKK GIECPWSNAD QVYFIAFSLL MLHTDYFNPN NKSKMTKHDF VDLVHNDKYS 600
  601 GGNEIPMAVL TYFYENVTAK ESPKFNYFLM SPMALDDSIL DKDAFDTNFA ITLSSNSMYS 660
  661 PIDMIKRGSI IPKEASLSPI FYPLTNSISA SGIAPSTAAS CPPSTSGTIN GANLGTANSN 720
  721 SNRPASNSIS SYFSYNPSSS SSGNATLVQD DINVYSHIIN DTLNEVNLFP EVSKYWNKNA 780
  781 LKANLLRNEE HKYEKYYSIM NDTKGGYLRF HKSQLNKLNL PNFEILNDNS RSGCKNSDYK 840
  841 YCKILQMGAI MNLGMPSRKF SIVNSAKIHW KKEFAILTSL GLLICDKMDW INPQMMKDPK 900
  901 SGTTNYIIDF KSGFSFVPGS TIDVYNGLFA DRERDSLGKS HFASLVLAYT EHHSTGSHTS 960
  961 NTTAASSSAK HNEGVFEPSS DEEDSITNST DGTSSVSNGE SDNDSVSSSD NQLSSNDSNE1020
 1021 DYHSIKDEYP IFEDENADCL LYLHTCHRNF IWKCANKYER DNWIDSINLF SAYDGCYVEI1080
 1081 GSIANTICNK RKLTILQRME RLRSIKSAKW EKLKKFESTL MLMGKCVPIS TKTKTDMINR1140
 1141 IRQLAVRMDW LIYEIKRSEL FVSIIKEVTR KQAEKNILEH GKGEEEGQGN NDDSDGIDDI1200
 1201 EESFLFNENS LQVCVSDSSY DEYSNE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..408] MSA 124.643997 View MSA. No confident structure predictions are available.
    2 View Details [409..489] PSI-BLAST 160.014858 Cytohesin-1/b2-1
    3 View Details [490..688] PSI-BLAST 160.014858 Cytohesin-1/b2-1
    4 View Details [689..1226] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • ARF guanyl-nucleotide exchange factor activity
    		•  3.21855719969171 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  2.45131212153136 bayes_pls_golite062009
  • binding
    		•  2.00452575860615 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.95409587538646 bayes_pls_golite062009
  • protein binding
    		•  1.10832780583804 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.206011675725808 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.16794422214995 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.134262037414542 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle