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View Structure Prediction Details

Protein: SYT1
Organism: Saccharomyces cerevisiae
Length: 1226 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYT1.

Description E-value Query
Range
Subject
Range
SYT1 - Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppress...
SYT1_YEAST - Arf guanine nucleotide exchange factor SYT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
0.0 [1..1226] [1..1226]
gi|225000702 - gi|225000702|gb|AAI72243.1| ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A...
ARFGEF1 - ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
2.0E-95 [334..730] [601..978]
BIG1_BOVIN - Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Bos taurus GN=ARFGEF1 PE=1 SV=1
3.0E-94 [334..730] [601..978]
gi|19879878 - gi|19879878|gb|AAM00191.1|AF262215_1 guanine nucleotide-exchange protein GEP2 [Oryza sativa]
2.0E-93 [321..732] [536..927]
BIG2_ARATH - Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Arabidopsis thaliana GN=BIG2 PE=2 SV=...
2.0E-92 [321..716] [515..896]
BIG2_RAT - Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Rattus norvegicus GN=Arfgef2 PE=1 SV=...
8.0E-91 [335..730] [560..930]
gi|50938413, gi|... - gi|50938413|ref|XP_478734.1| putative guanine nucleotide-exchange protein GEP2 [Oryza sativa (japoni...
3.0E-85 [330..716] [420..783]

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Predicted Domain #1
Region A:
Residues: [1-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQSISSLIK LKFLQSHSND KNGNKKGGSN VSTGIDKLRE SESYRSPFLQ LAEIQEHTNN  60
   61 DDDKLDVKEC EPTKKHSKLS RIRRKMGRLD LNFRSANEKG SEDDEILVAQ HLRNGQDPEE 120
  121 MPFKSENNID SIEKVPKPDG ERVTLTSSGS DNVKRNSKHA PFIPVKPALE KFPSSNRLSR 180
  181 DYRKSQEPTL FNGDRLVPTL PTVSRISTSS SVGSSTAASR YFNPSKRAVV ASSSSSSSSI 240
  241 KFNSLHAIPL DATPQIELAK QQDEISKRRF GRRRSRTVDV FDYINKNNTA KNKPPLSPSS 300
  301 FIRTIDEKNT NSLMQDPMGS RGPLLPDDAN IISNDTDGAE ASHPDHQVLS RSRSQSTSFV 360
  361 QGKGGKRKSI EDEGYHNKLG LPHGSGPTSV YNNKSNANST ITGMSRRS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [409-489]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSIVNALSSF VNLRSSSLSS SRQQHLQQQQ QLQQKLDVSL EDLPPVPAPE FSDSCKDFLI  60
   61 KLAPYGKFIG IILTEKDDEF K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 160.014858
Match: 1bc9__
Description: Cytohesin-1/b2-1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [490-688]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNCLNYLLTN CFEFKNDPLD IALRKLLMFL ELPKETQQID RLIMAFSFAY YKAQKSYSKK  60
   61 KGIECPWSNA DQVYFIAFSL LMLHTDYFNP NNKSKMTKHD FVDLVHNDKY SGGNEIPMAV 120
  121 LTYFYENVTA KESPKFNYFL MSPMALDDSI LDKDAFDTNF AITLSSNSMY SPIDMIKRGS 180
  181 IIPKEASLSP IFYPLTNSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 160.014858
Match: 1bc9__
Description: Cytohesin-1/b2-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ARF guanyl-nucleotide exchange factor activity 3.21855719969171 bayes_pls_golite062009
small GTPase regulator activity 2.45131212153136 bayes_pls_golite062009
binding 2.00452575860615 bayes_pls_golite062009
enzyme regulator activity 1.95409587538646 bayes_pls_golite062009
protein binding 1.10832780583804 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.206011675725808 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.16794422214995 bayes_pls_golite062009
GTPase regulator activity 0.134262037414542 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [689-1226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASGIAPSTA ASCPPSTSGT INGANLGTAN SNSNRPASNS ISSYFSYNPS SSSSGNATLV  60
   61 QDDINVYSHI INDTLNEVNL FPEVSKYWNK NALKANLLRN EEHKYEKYYS IMNDTKGGYL 120
  121 RFHKSQLNKL NLPNFEILND NSRSGCKNSD YKYCKILQMG AIMNLGMPSR KFSIVNSAKI 180
  181 HWKKEFAILT SLGLLICDKM DWINPQMMKD PKSGTTNYII DFKSGFSFVP GSTIDVYNGL 240
  241 FADRERDSLG KSHFASLVLA YTEHHSTGSH TSNTTAASSS AKHNEGVFEP SSDEEDSITN 300
  301 STDGTSSVSN GESDNDSVSS SDNQLSSNDS NEDYHSIKDE YPIFEDENAD CLLYLHTCHR 360
  361 NFIWKCANKY ERDNWIDSIN LFSAYDGCYV EIGSIANTIC NKRKLTILQR MERLRSIKSA 420
  421 KWEKLKKFES TLMLMGKCVP ISTKTKTDMI NRIRQLAVRM DWLIYEIKRS ELFVSIIKEV 480
  481 TRKQAEKNIL EHGKGEEEGQ GNNDDSDGID DIEESFLFNE NSLQVCVSDS SYDEYSNE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle