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Protein Overview: SPE2

General Information:
Name(s) found: SPE2 / YOL052C [SGD]
Description(s) found:
Found 28 descriptions.
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  • S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 396 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: pantothenate biosynthetic process [IMPLink to PubMed article]
    spermidine biosynthetic process [IMPLink to PubMed article]
    spermine biosynthetic process [IMPLink to PubMed article]
    Molecular Function: adenosylmethionine decarboxylase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVTIKELTN HNYIDHELSA TLDSTDAFEG PEKLLEIWFF PHKKSITTEK TLRNIGMDRW  60
   61 IEILKLVKCE VLSMKKTKEL DAFLLSESSL FVFDHKLTMK TCGTTTTLFC LEKLFQIVEQ 120
  121 ELSWAFRTTQ GGKYKPFKVF YSRRCFLFPC KQAAIHQNWA DEVDYLNKFF DNGKSYSVGR 180
  181 NDKSNHWNLY VTETDRSTPK GKEYIEDDDE TFEVLMTELD PECASKFVCG PEASTTALVE 240
  241 PNEDKGHNLG YQMTKNTRLD EIYVNSAQDS DLSFHHDAFA FTPCGYSSNM ILAEKYYYTL 300
  301 HVTPEKGWSY ASFESNIPVF DISQGKQDNL DVLLHILNVF QPREFSMTFF TKNYQNQSFQ 360
  361 KLLSINESLP DYIKLDKIVY DLDDYHLFYM KLQKKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MRS1 RPL42B, RPL42A SEO1 SPE2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SPE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] PSI-BLAST 487.0 S-adenosylmethionine decarboxylase
    2 View Details [200..396] PSI-BLAST 487.0 S-adenosylmethionine decarboxylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • adenosylmethionine decarboxylase activity
    		•  6.97190143843809 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  2.68228786608236 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.55250570844159 bayes_pls_golite062009
  • binding
    		•  1.4725833406744 bayes_pls_golite062009
  • catalytic activity
    		•  1.25843830926101 bayes_pls_golite062009
  • lyase activity
    		•  0.834955527171148 bayes_pls_golite062009
  • protein binding
    		•  0.443666756110255 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle