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Protein Overview: TOM40

General Information:
Name(s) found: TOM40 / YMR203W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 387 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed article]
    mitochondrial outer membrane translocase complex [IPILink to PubMed article]
    Biological Process: protein import into mitochondrial matrix [IPILink to PubMed article]
    Molecular Function: protein transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPTPLAEA SQIPTIPALS PLTAKQSKGN FFSSNPISSF VVDTYKQLHS HRQSLELVNP  60
   61 GTVENLNKEV SRDVFLSQYF FTGLRADLNK AFSMNPAFQT SHTFSIGSQA LPKYAFSALF 120
  121 ANDNLFAQGN IDNDLSVSGR LNYGWDKKNI SKVNLQISDG QPTMCQLEQD YQASDFSVNV 180
  181 KTLNPSFSEK GEFTGVAVAS FLQSVTPQLA LGLETLYSRT DGSAPGDAGV SYLTRYVSKK 240
  241 QDWIFSGQLQ ANGALIASLW RKVAQNVEAG IETTLQAGMV PITDPLMGTP IGIQPTVEGS 300
  301 TTIGAKYEYR QSVYRGTLDS NGKVACFLER KVLPTLSVLF CGEIDHFKND TKIGCGLQFE 360
  361 TAGNQELLML QQGLDADGNP LQALPQL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MPM1 TOM40
    View Details Hazbun TR, et al. (2003) ADH1 KAP123 MIA40 TIM50 TOM40
    View Details (MIPS) Mewes HW, et al. (2004) SAM37 TOM20 TOM22 TOM40 TOM5 TOM6 TOM7 TOM70 TOM71
    View Details Gavin AC, et al. (2006) MPM1 RPS25B TOM40 YGR130C
    View Details Gavin AC, et al. (2002) MDM10 MPM1 RVB2 TOM40
    View Details Qiu et al. (2008) MDJ2 TIM22 TOM20 TOM22 TOM40 TOM5 TOM6 TOM7 TOM70

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run TIM50 No Comments Hazbun TR, et al. (2003)
    View Run TIM50 No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] MSA 5.072992 View MSA. No confident structure predictions are available.
    2 View Details [159..227] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [228..387] MSA 8.075988 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle