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Protein Overview: GTR1

General Information:
Name(s) found: GTR1 / YML121W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 310 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    late endosome membrane [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    vacuolar membrane [IDALink to PubMed article]
    Biological Process: transcription from RNA polymerase III promoter [IMPLink to PubMed article][IPILink to PubMed article]
    phosphate transport [IMPLink to PubMed article]
    transcription from RNA polymerase I promoter [IMPLink to PubMed article][IPILink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: GTPase activity [IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNNRKKLL LMGRSGSGKS SMRSIIFSNY SAFDTRRLGA TIDVEHSHLR FLGNMTLNLW  60
   61 DCGGQDVFME NYFTKQKDHI FQMVQVLIHV FDVESTEVLK DIEIFAKALK QLRKYSPDAK 120
  121 IFVLLHKMDL VQLDKREELF QIMMKNLSET SSEFGFPNLI GFPTSIWDES LYKAWSQIVC 180
  181 SLIPNMSNHQ SNLKKFKEIM NALEIILFER TTFLVICSSN GENSNENHDS SDNNNVLLDP 240
  241 KRFEKISNIM KNFKQSCTKL KSGFKTLILN NNIYVSELSS NMVCFIVLKD MNIPQELVLE 300
  301 NIKKAKEFFQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CLG1 CUE1 GTR1 HAM1 HRT1 LAP3 TFP1 VMA10 VMA13 VMA2 VMA7 VMA8 XDJ1 YIG1
    View Details Qiu et al. (2008) GTR1 GTR2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RPC19 GTR1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GTR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..234] PSI-BLAST 51.09691 Rab-related protein Sec4
    2 View Details [235..310] MSA 1.26999 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle