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Protein Overview: VPS9

General Information:
Name(s) found: VPS9 / YML097C [SGD]
Description(s) found:
Found 19 descriptions.
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  • A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 451 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: guanyl-nucleotide exchange factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDDEKREIL KEFDPFSQLE QANGNPDKDV KFKKDDPNRA AAEETNRDIS AQDKGDEEPF  60
   61 YDFQIFIKQL QTPGADPLVK YTKSFLRNFL AQRLLWTVSE EIKLISDFKT FIYDKFTLYE 120
  121 PFRSLDNSKM RNAKEGMEKL IMGKLYSRCF SPSLYEILQK PLDDEHMKDL TNDDTLLEKI 180
  181 RHYRFISPIM LDIPDTMPNA RLNKFVHLAS KELGKINRFK SPRDKMVCVL NASKVIFGLL 240
  241 KHTKLEQNGA DSFIPVLIYC ILKGQVRYLV SNVNYIERFR SPDFIRGEEE YYLSSLQAAL 300
  301 NFIMNLTERS LTIEDHEDFE EAYQRNFKQL AEEKEEEEKK KQLEIPDELQ PNGTLLKPLD 360
  361 EVTNIVISKF NELFSPIGEP TQEEALKSEQ SNKEEDVSSL IKKIEENERK DTLNTLQNMF 420
  421 PDMDPSLIED VCIAKKSRIG PCVDALLSLS E

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8 VPS9

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..451] ORFEUS 8.62 (+)-bornyl diphosphate synthase
    2 View Details [343..451] PSI-BLAST 20.522879 Vacuolar protein sorting-associated protein vps9

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.53503231216012 bayes_pls_golite062009
  • GTPase activating protein binding
    		•  1.51214503459935 bayes_pls_golite062009
  • binding
    		•  1.29582735439414 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.345541740813359 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein binding
    		•  1.47354515839445 bayes_pls_golite062009
  • binding
    		•  1.17122954376528 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.439354773090226 bayes_pls_golite062009
  • ubiquitin binding
    		•  0.39987290017167 bayes_pls_golite062009
  • small conjugating protein binding
    		•  0.29743331442479 bayes_pls_golite062009
  • catalytic activity
    		•  0.25774924710417 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.22096204412796 bayes_pls_golite062009
  • enzyme binding
    		•  0.11064857638311 bayes_pls_golite062009
  • DNA binding
    		•  0.0423628856798978 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle