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View Structure Prediction Details

Protein: VPS9
Organism: Saccharomyces cerevisiae
Length: 451 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS9.

Description E-value Query
Range
Subject
Range
VPS9_YEAST - Vacuolar protein sorting-associated protein 9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
VPS9 - A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specif...
0.0 [1..451] [1..451]
ENSPTRT00000055439 - null
gi|61359644, gi|... - gi|61359653|gb|AAX41748.1| RAB guanine nucleotide exchange factor [synthetic construct], gi|61359644...
gi|6013006, gi|3... - gi|77176717|gb|ABA64473.1| RAP1 [Homo sapiens], gi|7657496|ref|NP_055319.1| RAB guanine nucleotide e...
2.0E-85 [39..373] [121..434]
RABX5_BOVIN - Rab5 GDP/GTP exchange factor OS=Bos taurus GN=RABGEF1 PE=1 SV=1
7.0E-84 [39..373] [122..435]
RABX5_MOUSE - Rab5 GDP/GTP exchange factor OS=Mus musculus GN=Rabgef1 PE=1 SV=1
1.0E-81 [39..373] [121..434]
vps901 - guanyl-nucleotide exchange factor Vps901
VPS91_SCHPO - Vacuolar protein sorting-associated protein 9a OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
8.0E-79 [14..349] [65..393]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-69 [12..330] [30..355]

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Predicted Domain #1
Region A:
Residues: [1-451]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDDEKREIL KEFDPFSQLE QANGNPDKDV KFKKDDPNRA AAEETNRDIS AQDKGDEEPF  60
   61 YDFQIFIKQL QTPGADPLVK YTKSFLRNFL AQRLLWTVSE EIKLISDFKT FIYDKFTLYE 120
  121 PFRSLDNSKM RNAKEGMEKL IMGKLYSRCF SPSLYEILQK PLDDEHMKDL TNDDTLLEKI 180
  181 RHYRFISPIM LDIPDTMPNA RLNKFVHLAS KELGKINRFK SPRDKMVCVL NASKVIFGLL 240
  241 KHTKLEQNGA DSFIPVLIYC ILKGQVRYLV SNVNYIERFR SPDFIRGEEE YYLSSLQAAL 300
  301 NFIMNLTERS LTIEDHEDFE EAYQRNFKQL AEEKEEEEKK KQLEIPDELQ PNGTLLKPLD 360
  361 EVTNIVISKF NELFSPIGEP TQEEALKSEQ SNKEEDVSSL IKKIEENERK DTLNTLQNMF 420
  421 PDMDPSLIED VCIAKKSRIG PCVDALLSLS E

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.62
Match: 1n1bA
Description: (+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.53503231216012 bayes_pls_golite062009
GTPase activating protein binding 1.51214503459935 bayes_pls_golite062009
binding 1.29582735439414 bayes_pls_golite062009
enzyme regulator activity 0.345541740813359 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [343-451]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEIPDELQPN GTLLKPLDEV TNIVISKFNE LFSPIGEPTQ EEALKSEQSN KEEDVSSLIK  60
   61 KIEENERKDT LNTLQNMFPD MDPSLIEDVC IAKKSRIGPC VDALLSLSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.522879
Match: 1mn3A
Description: Vacuolar protein sorting-associated protein vps9
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.47354515839445 bayes_pls_golite062009
binding 1.17122954376528 bayes_pls_golite062009
nucleic acid binding 0.439354773090226 bayes_pls_golite062009
ubiquitin binding 0.39987290017167 bayes_pls_golite062009
small conjugating protein binding 0.29743331442479 bayes_pls_golite062009
catalytic activity 0.25774924710417 bayes_pls_golite062009
transcription regulator activity 0.22096204412796 bayes_pls_golite062009
enzyme binding 0.11064857638311 bayes_pls_golite062009
DNA binding 0.0423628856798978 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle